Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5-HMF Attenuates Liver Fibrosis in CCl4-Plus-Alcohol-Induced Mice by Suppression of Oxidative Stress

(2017) Xin-yue HAN et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy

(2016) Kan Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis

(2016) Shu Dong et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Oncogenic role of the Notch pathway in primary liver cancer

(2016) JIE LU et al.   Oncology Letters

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

(2016) Chuanyong Guo et al.   Drug Design Development and Therapy

In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity

(2016) Sainan Li et al.   Scientific Reports

Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling

(2016) Jiafa Ren et al.   Scientific Reports

Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis

(2016) Jingjing Li et al.   PLoS One

The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway

(2015) Dong-ke Yu et al.   ACTA PHARMACOLOGICA SINICA

Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy

(2015) Yuqing Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice

(2015) Jingjing Li et al.   Marine Drugs

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

(2015) Yuqing Mao et al.   Drug Design Development and Therapy

Ethyl acetate fraction of Amomum xanthioides improves bile duct ligation-induced liver fibrosis of rat model via modulation of pro-fibrogenic cytokines

(2015) Hyeong-Geug Kim et al.   Scientific Reports

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis

(2015) Jingjing Li et al.   PLoS One

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway

(2015) Jia Wang et al.   Oncotarget

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

(2014) Y. Wan et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways

(2014) Ping Cheng et al.   MEDIATORS OF INFLAMMATION

Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy

(2014) Miao Shen et al.   MEDIATORS OF INFLAMMATION

Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction

(2014) YANG YAN et al.   Experimental and Therapeutic Medicine

Autophagy: A Multifaceted Partner in Liver Fibrosis

(2014) Ariane Mallat et al.   Biomed Research International

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

(2013) Crystal Rocher et al.   PLoS One

Attenuation of CCl4-Induced Hepatic Fibrosis in Mice by Vaccinating against TGF-β1

(2013) Xiaobao Fan et al.   PLoS One

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance

(2012) Luis Daniel Hernández-Ortega et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis1–3

(2012) Eder Marcolin et al.   JOURNAL OF NUTRITION

Liver fibrosis: mechanisms of immune-mediated liver injury

(2011) Ruonan Xu et al.   Cellular & Molecular Immunology

Chemoprotective Mechanism of the Natural Compounds, Epigallocatechin- 3-O-Gallate, Quercetin and Curcumin Against Cancer and Cardiovascular Diseases

(2009) Smita Jagtap et al.   CURRENT MEDICINAL CHEMISTRY

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells

(2009) Pau Sancho-Bru et al.   LIVER INTERNATIONAL

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Health effects of quercetin: From antioxidant to nutraceutical

(2008) Agnes W. Boots et al.   EUROPEAN JOURNAL OF PHARMACOLOGY