Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of itsin vivosynergism with gemcitabine, in pancreatic adenocarcinoma mouse models

Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

(2015) Giuseppe Di Caro et al.   GUT

High infiltration of tumor-associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer

(2015) Keijiro Sugimura et al.   JOURNAL OF SURGICAL ONCOLOGY

Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma

(2014) Kirsten Kübler et al.   GYNECOLOGIC ONCOLOGY

Radiotherapy Combined with Gemcitabine and Oxaliplatin in Pancreatic Cancer Cells

(2014) Meredith A. Morgan et al.   Translational Oncology

Impact of tumour associated macrophages in pancreatic cancer

(2013) Ainhoa Mielgo et al.   BMB Reports

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

(2013) Xiaoqiang Tang   CANCER LETTERS

Comparison ofin vitroandin vivobiological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104)

(2013) Michela Romano et al.   INTERNATIONAL JOURNAL OF CANCER

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse

(2013) Silke Reinartz et al.   INTERNATIONAL JOURNAL OF CANCER

Intraoperative radiotherapy for breast cancer

(2013) David Azria et al.   LANCET

Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase

(2013) N Weizman et al.   ONCOGENE

Trabectedin

(2013) Paola Allavena et al.   OncoImmunology

Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer

(2012) A. Vidal et al.   CLINICAL CANCER RESEARCH

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

(2011) P. Allavena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Identification and manipulation of tumor associated macrophages in human cancers

(2011) Moniek Heusinkveld et al.   Journal of Translational Medicine

Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells

(2011) D. G. Soares et al.   MOLECULAR CANCER THERAPEUTICS

Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations

(2011) Juan A. Bueren-Calabuig et al.   NUCLEIC ACIDS RESEARCH

The Tissue Microlocalisation and Cellular Expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 Is Correlated to Clinical Outcome in NSCLC

(2011) Chandra M. Ohri et al.   PLoS One

PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity

(2010) JFM Leal et al.   BRITISH JOURNAL OF PHARMACOLOGY