Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate

(2019) Phillip T. Newton et al.   NATURE

A Computed Microtomography Method for Understanding Epiphyseal Growth Plate Fusion

(2018) Katherine A. Staines et al.   Frontiers in Materials

TIMP loss activates metalloproteinase-TNFα-DKK1 axis to compromise Wnt signaling and bone mass

(2018) Yan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Resting zone of the growth plate houses a unique class of skeletal stem cells

(2018) Koji Mizuhashi et al.   NATURE

A degradation fragment of type X collagen is a real-time marker for bone growth velocity

(2017) Ryan F. Coghlan et al.   Science Translational Medicine

Knock-in human FGFR3 achondroplasia mutation as a mouse model for human skeletal dysplasia

(2017) Yi-Ching Lee et al.   Scientific Reports

Chondrocyte FGFR3 Regulates Bone Mass by Inhibiting Osteogenesis

(2016) Xuan Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

(2016) Lomeli R. Carpio et al.   Science Signaling

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

(2016) Lomeli R. Carpio et al.   Science Signaling

Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice

(2016) Junzhou Tang et al.   Arthritis & Rheumatology

Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice

(2015) Hartland W. Jackson et al.   NATURE CELL BIOLOGY

Isometric Scaling in Developing Long Bones Is Achieved by an Optimal Epiphyseal Growth Balance

(2015) Tomer Stern et al.   PLOS BIOLOGY

Fibroblast Growth Factor 2 Drives Changes in Gene Expression Following Injury to Murine Cartilage In Vitro and In Vivo

(2013) Ka-Wing Chong et al.   ARTHRITIS AND RHEUMATISM

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

(2013) P. E. Lapinski et al.   Disease Models & Mechanisms

Fundamental ratios and logarithmic periodicity in human limb bones

(2013) Alexis Pietak et al.   JOURNAL OF ANATOMY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice

(2012) A. E. Börjesson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

RNA extraction from human articular cartilage by chondrocyte isolation

(2012) Shabana Amanda Ali et al.   ANALYTICAL BIOCHEMISTRY

Nosology and classification of genetic skeletal disorders: 2010 revision

(2011) Matthew L. Warman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage

(2011) Heather Stanton et al.   Nature Protocols

Tissue inhibitors of metalloproteinases

(2011) Gillian Murphy   GENOME BIOLOGY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis

(2010) N. Su et al.   HUMAN MOLECULAR GENETICS

Mice with Tissue Inhibitor of Metalloproteinases 4 (Timp4) Deletion Succumb to Induced Myocardial Infarction but Not to Cardiac Pressure Overload

(2010) Ilpo Koskivirta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leg Length, Body Proportion, and Health: A Review with a Note on Beauty

(2010) Barry Bogin et al.   International Journal of Environmental Research and Public Health

Fibroblast growth factor 2: A new key player in osteoarthritis

(2009) Jelena Gavrilovic   ARTHRITIS AND RHEUMATISM

Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice

(2009) Alison Aiken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Zebrafish Embryo: A Powerful Model System for Investigating Matrix Remodeling

(2009) Rachael A. Wyatt et al.   Zebrafish

Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure

(2008) Hiromichi Kimura et al.   CANCER CELL

Meprins, membrane-bound and secreted astacin metalloproteinases

(2008) E STERCHI et al.   MOLECULAR ASPECTS OF MEDICINE

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols

The Degradome database: mammalian proteases and diseases of proteolysis

(2008) V. Quesada et al.   NUCLEIC ACIDS RESEARCH

Clipping, shedding and RIPping keep immunity on cue

(2008) Gillian Murphy et al.   TRENDS IN IMMUNOLOGY