Article
Multidisciplinary Sciences
Jingzhu Zhang, Liming Du, Bethany Davis, Zhimin Gu, Junhua Lyu, Zhiyu Zhao, Jian Xu, Sean J. Morrison, Francesca V. Mariani
Summary: Osteolectin is a growth factor that activates the Wnt pathway and promotes bone elongation by binding to Integrin a11. Its deficiency leads to shorter bones in mice, and reduced growth plate chondrocyte proliferation and bone elongation. Furthermore, a single-nucleotide variant associated with reduced height and plasma Osteolectin levels was found downstream of Osteolectin. This study establishes Osteolectin/Integrin a11 as regulators of bone elongation and body length in both mice and humans.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Tsz Long Chu, Peikai Chen, Anna Xiaodan Yu, Mingpeng Kong, Zhijia Tan, Kwok Yeung Tsang, Zhongjun Zhou, Kathryn Song Eng Cheah
Summary: This study reveals that MMP14 plays a crucial role in the regulation of PTH signaling, thus contributing to bone homeostasis. During the development of osteoblasts from HC-descendent cells, MMP14 and the PTH pathway are activated. MMP14 cleaves PTH1R to dampen PTH signaling, thereby regulating bone synthesis.
Article
Biochemistry & Molecular Biology
Lei Zhou, Haoran Li, Shiwei Sun, Tieqi Zhang, Yueming Yu, Liang Xu, Minghai Wang
Summary: This study reveals that Thrap3 promotes osteogenesis by inhibiting the degradation of Runx2 and the transcriptional activity of Sox9. This finding helps further understand the molecular mechanisms of osteogenic differentiation and provides a new potential target for the treatment of osteoporosis.
Article
Pharmacology & Pharmacy
Zhenyu Li, Huasong Shi, Yanmei Li, Wang Wang, Zhexi Li, Biao Chen, Daibang Nie
Summary: This study discovered that isorhynchophylline (IRN) has protective effects on human osteoarthritis (OA) chondrocytes. The protective effects of IRN may be attributed to its inhibition of the NF-kappa B pathway, which leads to a reduction in inflammatory and degenerative progression of OA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Martin Biosse Duplan, Emilie Dambroise, Valentin Estibals, Joelle Veziers, Je'rome Guicheux, Laurence Legeai-Mallet
Summary: The study showed that overactivation of FGFR3 in immature osteoblasts leads to bone modifications affecting bone growth and causing osteopenia. In contrast, activation of FGFR3 in mature osteoblasts has limited effects on skeletal shape and micro-architecture.
DISEASE MODELS & MECHANISMS
(2021)
Article
Medicine, Research & Experimental
Min Chu, Zhenyu Sun, Zhanghao Fan, Degang Yu, Yuanqing Mao, Yaping Guo
Summary: La-LDH nanohybrid scaffolds exhibit dual functions of promoting osteogenesis and inhibiting osteoclastogenesis, showing potential value for bone regeneration in osteoporotic patients.
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zixin Cai, Fen Liu, Yan Yang, Dandan Li, Shanbiao Hu, Lei Song, Shaojie Yu, Ting Li, Bilian Liu, Hairong Luo, Weiping Zhang, Zhiguang Zhou, Jingjing Zhang
Summary: The levels of GRB10, a negative regulator of insulin and mTORC1 signaling, are increased in diabetic mice and high glucose-treated cells. Knockout of Grb10 in mice increased beta-cell mass and improved function, while overexpression of Grb10 induced beta-cell dedifferentiation. GRB10 is identified as a critical regulator of beta-cell dedifferentiation and mass through inhibiting mTORC1 signaling.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Biology
Cong Xu, Van Vuong Dinh, Kai Kruse, Hyun-Woo Jeong, Emma C. Watson, Susanne Adams, Frank Berkenfeld, Martin Stehling, Seyed Javad Rasouli, Rui Fan, Rui Chen, Ivan Bedzhov, Qi Chen, Katsuhiro Kato, Mara E. Pitulescu, Ralf H. Adams
Summary: This study investigates whether treatment with secreted Notch ligand proteins can enhance osteogenesis in adult mice. The findings reveal that bone-targeted Delta-like 4 can induce bone formation in male mice without adverse effects in other organs. However, it fails to promote osteogenesis in female mice and ovariectomized mice, but significantly enhances trabecular bone formation when combined with parathyroid hormone. Single cell analysis indicates that Delta-like 4 primarily acts on MSCs with minor effects on other cell types. Therefore, activation of Notch signaling through bone-targeted fusion proteins could be therapeutically useful and avoid detrimental effects in other organs.
Article
Cell Biology
Weihui Qi, Yanlin Chen, Shuaibo Sun, Xinxian Xu, Jingdi Zhan, Zijian Yan, Ping Shang, Xiaoyun Pan, Haixiao Liu
Summary: Osteoarthritis (OA) is a common degenerative disease, and controlling local chronic inflammation is crucial for delaying its development. Studies have shown that Linarin can effectively suppress the overproduction of inflammatory substances in chondrocytes and exert protective effects by intervening NF-KB activation.
Article
Cell Biology
Zheng-Zhao Liu, Chun-Gu Hong, Wen-Bao Hu, Meng-Lu Chen, Ran Duan, Hong-Ming Li, Tao Yue, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Lang Xu, Si-Yuan Tang, Rong-Gui Hu, Hui Xie
Summary: Senile osteoporosis (OP) is associated with decreased autophagic activity, with OPTN playing a crucial role in bone metabolism through selective autophagy. Reduced expression of OPTN during aging may lead to OP due to impaired degradation of FABP3 via selective autophagy, which impairs osteogenesis of MSCs and contributes to bone loss. Reactivating OPTN or inhibiting FABP3 could be a potential treatment strategy for senile OP.
Article
Biochemistry & Molecular Biology
Dong Woo Kang, Won Chan Hwang, Yu Na Noh, Xiangguo Che, Soung-Hoon Lee, Younghoon Jang, Kang-Yell Choi, Je-Yong Choi, Do Sik Min
Summary: In osteoporosis, the balance between bone and fat mass is determined by phospholipase D1 (PLD1), which affects the differentiation of mesenchymal stem cells. Ablation of Pld1 decreases bone mass and increases fat, altering osteoblast and osteoclast differentiation. Loss of PLD1 promotes adipogenesis and hepatic steatosis while reducing osteogenesis, suggesting a role in maintaining homeostasis between bone and fat mass.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Jiangbo Yan, Gangning Feng, Yong Yang, Dong Ding, Long Ma, Xin Zhao, Xiaolei Chen, Hui Wang, Zhirong Chen, Qunhua Jin
Summary: This study evaluated the effects of autophagy on cartilage and subchondral bone in a mouse OA model. The findings showed that autophagy can delay the progression of OA in the early stages by improving cartilage thickness and subchondral bone remodeling. Mechanistically, autophagy activation increases the expression of type II collagen and decreases the expression of matrix metalloproteinase 13, leading to the inhibition of chondrocyte pyroptosis. In the subchondral bone, autophagy activation reduces osteoclast generation in the early stages and inhibits osteoblastogenesis in the late stages of OA.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Yongjian Chen, Khalid Mehmood, Yung-Fu Chang, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: Disorders of glycosaminoglycan synthesis can lead to skeletal developmental disorders, and understanding the cellular and molecular pathogenesis is crucial for addressing these orthopedic diseases. Glycosaminoglycan regulates chondrocyte differentiation and endochondral osteogenesis by modulating various growth factors and signaling molecules. By studying the molecular mechanisms underlying glycosaminoglycan synthesis, innovative approaches can be proposed for the treatment of orthopedic diseases caused by impaired glycosaminoglycan synthesis.
Article
Biochemistry & Molecular Biology
Xingchen Liu, Shudan Deng, Jiaxin Xie, Chunxin Xu, Zhuwei Huang, Baoxin Huang, Zhuofan Chen, Shoucheng Chen
Summary: Mechanical and chemical debridement can remove bacterial biofilms, but the effect of debridement on bone regeneration on the titanium surface is unclear. The study found that the debrided titanium surface can induce inflammatory response, but this can be reversed by using 2-DG, promoting bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yongkai Yuan, Hao Li, Junxiang Zhu, Chengzhen Liu, Xun Sun, Dongfeng Wang, Ying Xu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Oncology
Zi-Yuan Nie, Min Yao, Zhan Yang, Lin Yang, Xiao-Jun Liu, Jing Yu, Ying Ma, Nan Zhang, Xiao-Yan Zhang, Meng-Han Liu, Ling-Ling Jiang, Jian-Min Luo
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Shu-Jun Dong, Yun-Lin Jiang, Juan Peng, Chen-Xi Zhang, Qing Zhu, Qin-Qing Wang, Yi-Nan Liao, Wei-Ling Pi, Xi-Yang Dong, Jian-Ping Yuan, Jiang-Hai Wang
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Energy & Fuels
Stephen Ntiri Asomani, Jianping Yuan, Longyan Wang, Desmond Appiah, Kofi Asamoah Adu-Poku
Article
Virology
Wanwei Li, Yanlan Wang, Bo Yu, Qiqi Tan, Jijian Zhou, Jingjing Hu, Yuanbin Wu, Bo Wang, Hongjian Li
Article
Multidisciplinary Sciences
Michael Worku, Yu Tian, Chenkun Zhou, Haoran Lin, Maya Chaaban, Liang-jin Xu, Qingquan He, Drake Beery, Yan Zhou, Xinsong Lin, Yi-feng Su, Yan Xin, Biwu Ma
Article
Biochemistry & Molecular Biology
Yan Wu, Yin Wu, Jia Deng, Liuxi Chu, Haoran Yang, Wei Wang, Jiajun Liao, Yizhi Cheng, Huihua Deng
Article
Biology
Shuo Huang, Min Jin, Nan Su, Lin Chen
Summary: Bone has a strong regenerative capacity driven by reparative cells such as skeletal stem cells and their descendants, playing critical roles in bone development, maintenance, and injury healing. However, the identity and functional roles of skeletal stem cells remain controversial due to technological difficulties and cell heterogeneity. There has been a biased view for many years that bone marrow is the main source of reparative cells for bone repair.
BIOLOGICAL REVIEWS
(2021)
Article
Chemistry, Physical
Shuya Li, Saerona Kim, Andrew H. Davis, Jingshun Zhuang, Eric Wolfgang Shuler, Debora Willinger, Jae-Joon Lee, Weiwei Zheng, Benjamin D. Sherman, Chang Geun Yoo, Gyu Leem
Summary: Selective cleavage of C-C bonds in lignin at ambient temperature was achieved using a HAT-DSPEC system, which combines a dye-sensitized photoelectrochemical cell with a hydrogen atom transfer mediator under redox-neutral conditions. The system demonstrated excellent efficiency and selectivity in the cleavage of the C(aryl)-C(alkyl) bond under solar irradiation.
Proceedings Paper
Computer Science, Information Systems
Yizhong Xu, Siyi Cao, Jiafang Ji, Qin Xiao, Anqi Wu, Xiuyuan Wang
2020 ASIA-PACIFIC SIGNAL AND INFORMATION PROCESSING ASSOCIATION ANNUAL SUMMIT AND CONFERENCE (APSIPA ASC)
(2020)
Article
Geology
Tian Jian, Teng XueJian, Xin HouTian, Duan XiaoLong, Cheng XianYu, Zhang Yong, Ren BangFang
ACTA PETROLOGICA SINICA
(2020)
Review
Pharmacology & Pharmacy
Huanrong Lan, Wei Zhang, Ketao Jin, Yuyao Liu, Zhen Wang
Article
Environmental Sciences
Difei Zhao, Yinghai Guo, Geoff Wang, Weiwei Jiao, Jing Liu, Yang Hui
FRESENIUS ENVIRONMENTAL BULLETIN
(2020)
Article
Materials Science, Biomaterials
Yuli Bai, Rui Zhou, Lei Wu, Yaxian Zheng, Xi Liu, Ruinan Wu, Xiang Li, Yuan Huang
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Health Policy & Services
Xiaojing Huang, Mei Sun, Yu Song, Chengyue Li, Rong Jin, Heqi Sun, Weili Wang, Qi Zhang, Jun Lu
INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT
(2020)
