Article
Immunology
Wagdi Almishri, Liam A. Swain, Charlotte D'Mello, Tyson S. Le, Stefan J. Urbanski, Henry H. Nguyen
Summary: Increased expression of ADAM17 is observed in cholestatic liver diseases. Inhibition of ADAM17 activity improves liver injury and associated sickness behavior development, suggesting that ADAM17 inhibition may be a potential therapeutic approach for patients with cholestatic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kaja Michalczyk, Aneta Cymbaluk-Ploska
Summary: Matrix metalloproteinases (MMPs) play a crucial role in the development and progression of endometrial cancer, with significantly elevated levels in cancer patients compared to normal individuals. Understanding the role of MMPs may have implications for diagnosis and treatment of endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney
Summary: Extracellular proteolysis and turnover play crucial roles in tissue homeostasis. MMPs, as the main matrix-degrading enzymes, are regulated by TIMPs. The balance between MMP activity and TIMP levels is essential for healthy tissue homeostasis and can be disrupted in pathological conditions.
Article
Biochemistry & Molecular Biology
Angela Oranger, Roberta Zerlotin, Cinzia Buccoliero, Lorenzo Sanesi, Giuseppina Storlino, Ernestina Schipani, Kenneth Michael Kozloff, Giorgio Mori, Graziana Colaianni, Silvia Colucci, Maria Grano
Summary: Bone fractures are a common clinical event caused by falls, trauma, diseases, and aging. Recent research has found a link between irisin and bone fractures. In an experiment on mice with tibial fractures, treatment with r-Irisin reduced inflammation and promoted angiogenesis, cartilage matrix degradation, and bone formation, suggesting it as a potential molecule for fracture treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ya-Li Zhang, Liang Liu, Yaser Peymanfar, Paul Anderson, Cory J. Xian
Summary: The differentiation switch of BMSCs can lead to changes in bone/fat formation in the bone marrow, causing bone growth defects and disordered bone metabolism. MicroRNAs may play a significant role in regulating this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Griffin A. Greco, Mitchell Rock, Matthew Amontree, Maria Fe Lanfranco, Holly Korthas, Sung Hyeok Hong, R. Scott Turner, G. William Rebeck, Katherine Conant
Summary: The APOE4 allele increases the risk for Alzheimer's disease in a dose-dependent manner and is associated with cognitive decline. A study using mice with targeted gene replacement showed that APOE4 reduces neuronal dendritic complexity and impairs learning. APOE4 also reduces gamma oscillation power, important for learning and memory. The present study found that CCL5, an ECM effector, is increased in CSF samples from APOE4 individuals, and TIMPs, which inhibit ECM-degrading enzymes, are increased in APOE4 CSF and brain lysates. Knockout of CCR5, a receptor for CCL5, enhanced gamma power and improved learning and memory.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Infectious Diseases
Bastian Lubis, Aznan Lelo, Putri Amelia, Agus Prima
Summary: This study was a randomized controlled trial examining the effects of vitamin C and thiamine in septic patients. The study found that thiamine alone provided better advantages than either vitamin C alone or their combination.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Multidisciplinary Sciences
Qian Chen, ZuPing Wu, Liang Xie
Summary: Intercellular communication between immune and skeletal cells plays a crucial role in regulating bone homeostasis. Progranulin (PGRN), an autocrine growth factor, is involved in various pathological processes and regulates inflammation progression and bone formation through competing with tumor necrosis factor receptor 1 (TNFR1) and agonizing tumor necrosis factor receptor 2 (TNFR2). Exploiting PGRN and its derivative Atsttrin may have potential therapeutic benefits for inflammatory bone diseases.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ewa Tomaszewska, Halyna Rudyk, Izabela Swietlicka, Monika Hulas-Stasiak, Janine Donaldson, Marta Arczewska, Siemowit Muszynski, Piotr Dobrowolski, Maria Mielnik-Blaszczak, Marcin Bartlomiej Arciszewski, Volodymyr Kushnir, Oksana Brezvyn, Viktor Muzyka, Ihor Kotsyumbas
Summary: Exposure to fumonisins during pregnancy negatively impacts offspring bone development by altering bone metabolism and affecting the expression of proteins responsible for bone matrix degradation in a dose- and sex-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Deep Sankar Rudra, Uttam Pal, Nilkanta Chowdhury, Nakul Chandra Maiti, Angshuman Bagchi, Snehasikta Swarnakar
Summary: The repairing of damaged tissues in the gastric tract starts with extracellular matrix remodeling by matrix metalloproteinases (MMPs). The drug omeprazole, used to cure gastric ulcers, has been shown to restore MMP-2 activity and reduce apoptosis, preventing stress-induced gastric ulcers by modulating NF-kappa B and PPAR-gamma activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zhouyangfan Peng, Mingwu Duan, Yiting Tang, Jianfeng Wu, Kai Zhao, Yanjun Zhong, Zhihui He, Jie Meng, Fangping Chen, Xianzhong Xiao, Haichao Wang, Timothy R. Billiar, Ben Lu, Fang Liang
Summary: Silicosis is caused by inhalation of crystalline silica dust particles, and impaired interferon gamma signaling in myeloid cells is strongly associated with the occurrence of the disease. Interferon gamma priming of macrophages can partially inhibit the inflammatory response induced by crystalline silica.
Article
Pharmacology & Pharmacy
Qinghai Zhu, Yuting Tang, Tian Zhou, Li Yang, Gao Zhang, Ying Meng, Huixin Zhang, Jun Gao, Chenxing Wang, Yu-Xiong Su, Jinhai Ye
Summary: This study found that exosomes derived from pre-differentiated AB-BMSCs carrying specific miRNAs have a positive effect on bone regeneration. The 7-day pre-differentiation of exosomes effectively promoted BMSCs differentiation and activated the PI3K/Akt signaling pathway through differential expression of miRNAs. Gene modification of exosomes provides great potential as a bone regeneration strategy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Aliciane de Almeida Roque, Jessica Zablocki da Luz, Michelle Thays Khun Santurio, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro
Summary: In this study, the effects of pesticides widely used in Brazil and their main metabolites on the malignancy of melanoma cells were investigated. The results showed that these chemicals modulate important parameters of tumor progression, such as gene expression related to tumor aggressiveness and multidrug resistance. These findings raise concerns about the increasing trend in pesticide use in Brazil and its potential negative impact on melanoma progression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Zdanowicz, Monika Kowalczuk-Kryston, Witold Olanski, Irena Werpachowska, Wlodzimierz Mielech, Dariusz Marek Lebensztejn
Summary: This study explores the early effects of alcohol intoxication on liver fibrosis in adolescents. The results show that even a single episode of alcohol intoxication can lead to an imbalance in markers of fibrosis.
Article
Environmental Sciences
Yonggang Ma, Di Ran, Xueni Shi, Hongyan Zhao, Zongping Liu
Summary: Cadmium is a widespread environmental contaminant that causes severe bone metabolism disease and dental issues. It affects bone cell and teeth development, leading to oxidative stress and DNA damage, ultimately resulting in cell apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Sanjay Saw, Naveen Arora
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Preeti Bansal, Sanjay Saw, Dhanapal Govindaraj, Naveen Arora
FREE RADICAL BIOLOGY AND MEDICINE
(2014)
Article
Cell Biology
Sanjay Saw, Naveen Arora
Article
Multidisciplinary Sciences
Sanjay Saw, Sagar Laxman Kale, Naveen Arora
Article
Cell Biology
Sanjay Saw, Alison Aiken, Hui Fang, Trevor D. Mckee, Sarah Bregant, Otto Sanchez, Yan Chen, Ashley Weiss, Brendan C. Dickson, Bertrand Czarny, Ankit Sinha, Amanda Fosang, Vincent Dive, Paul D. Waterhouse, Thomas Kislinger, Rama Khokha
JOURNAL OF CELL BIOLOGY
(2019)
Review
Immunology
Sanjay Saw, Ashley Weiss, Rama Khokha, Paul D. Waterhouse
TRENDS IN IMMUNOLOGY
(2019)