Article
Endocrinology & Metabolism
Ryan F. Coghlan, Robert C. Olney, Bruce A. Boston, Daniel T. Coleman, Brian Johnstone, William A. Horton
Summary: The study found that the bone growth by-product CXM in blood can serve as a potential means to estimate height velocity in real time. Specific working reference ranges have been established for assessing skeletal growth, especially over time, in both girls and boys. CXM stability in stored samples makes it well suited for retrospective studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Engineering, Mechanical
Yueguang Gao, Shunshan Feng, Xiang Xiao, Bo Zhang, Qi Huang
Summary: This study investigates a cylinder with discontinuous charges and finds that detonating two charge parts simultaneously in the air part creates a high-pressure zone, accelerating the air part and the nearby charge part casings. The simulation results are verified by X-ray radiography, and a formula is established to predict the fragment velocity distribution with an average relative error of less than 4.5%.
INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
(2023)
Article
Chemistry, Physical
Jun Fu, Linghong Zeng, Chuang Sheng, Ziang Guo, Beijia Li, Zhonghua Deng, Xi Li
Summary: This work presents a real-time power allocation algorithm to deal with uncertain driving conditions for fuel cell hybrid vehicles. A fusion prediction model based on the advantages of Markov chain and neural network is developed to predict the vehicle speed. The optimal power splitting decision in each receding horizon is solved using the Pontryagin's minimum principle method, taking into account fuel consumption, State of Charge (SOC), and performance degradation. An electrochemical active surface area degradation model based on Pt catalyst dissolution is developed to evaluate the effect of the energy management algorithm on fuel cell degradation. Compared with conventional real-time power splitting strategies, the approach suggested in this research shows better performance in reducing fuel consumption, maintaining battery SOC stability, and considering fuel cell degradation.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Engineering, Mechanical
Ping Ye, Qitian Sun, Qian Gao, Wei Hao, Xuanyi An, Yongxiang Dong
Summary: This work introduces a novel fragmentation warhead that can produce two groups of fragments with different velocity characteristics and strike the target sequentially. The results of X-ray radiography experiment and 3D smooth-particle hydrodynamics numerical simulation indicate that the proposed formula is accurate and reliable in calculating the fragment velocity.
INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
(2021)
Article
Polymer Science
Marta Vallecillo-Rivas, Manuel Toledano-Osorio, Cristina Vallecillo, Manuel Toledano, Raquel Osorio
Summary: This study investigated the biodegradation pattern of five collagen membranes from different origins, with Evolution X-fine collagen membrane from porcine pericardium showing the highest resistance. On the other hand, Biocollagen and Parasorb Resodont from equine origin experienced the greatest degradation in certain challenge tests. Bacterial collagenase solution was found to be the most aggressive testing method.
Article
Engineering, Mechanical
Yueguang Gao, Shunshan Feng, Xiang Xiao, Yuan Feng, Qi Huang
Summary: This study analyzed the fragment characteristics and acceleration process of a partially constrained cylinder using X-ray radiography and numerical simulation. A new formula was proposed to predict the fragment velocity distribution of the constrained cylinder. The results showed that the fragment size and kinetic energy near the constrained end increased as the radial pressure gradient decreased, and the fragment velocity exceeded the maximum velocity calculated by the Gurney equation.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fan Rui, Kang Jiawei, Hao Yuntao, Liu Xinran, Hu Jiani, Mao Ruixue, Liu Rui, Zhu Na, Xu Meihong, Li Yong
Summary: The study aimed to confirm the preventive and therapeutic effects of undenatured type II collagen (UC II) on osteoarthritis in aging db/db mice and T2DM patients. By UC II intervention, significant improvement in motor functions and serum biomarker levels was observed in aging db/db mice, as well as pain relief, enhanced physical function, and increased walking ability and mobility distance in T2DM patients with knee OA.
Article
Engineering, Civil
B. R. Heyer, T. C. Osorno, J. F. Devlin
Summary: The In-Well Point Velocity Probe (IWPVP) was originally developed for use in screened porous media wells but was adapted to characterize flow in fractured media. Experimental results showed that the probe could reliably measure horizontal flux and flow direction in a single fracture without reference to Darcy's Law.
JOURNAL OF HYDROLOGY
(2021)
Article
Engineering, Multidisciplinary
Jun Song, Dong Hyuk Kim, Seong Han Kim
Summary: This study introduces a measurement system for detecting spalling phenomena in ball-type constant velocity joints (CVJ) and measuring adhesive wear depth in real time. The system consists of three subsystems: applying normal force, creating reciprocal yaw motion, and measurement with a resolution of 0.18 degrees/micrometer. The system's results were validated by comparing with profilometer measurement data of a tested ball-type CVJ.
Article
Endocrinology & Metabolism
L. E. Nicol, R. F. Coghlan, D. Cuthbertson, Sandesh C. S. Nagamani, B. Lee, R. C. Olney, W. Horton, E. Orwoll
Summary: Abnormalities in type I collagen can cause osteogenesis imperfecta, leading to bone fragility and growth retardation. Levels of type X collagen (CXM) are correlated with growth rate, with children with OI showing greater variability in CXM levels compared to controls. This disruption suggests dysfunction in the hypertrophic zone and skeletal growth endpoint in OI patients.
Article
Dentistry, Oral Surgery & Medicine
Arwa Bafail, Karina Midori Mori Carneiro, Anil Kishen, Anuradha Prakki
Summary: The study evaluated the effect of Odanacatib inhibitor treatment on lipopolysaccharide (LPS) contamination-induced dentin degradation mediated by cathepsin-K. Results showed that LPS contamination significantly increased the release rates of telopeptides from dentin matrix, while Odanacatib treatment significantly reduced the telopeptide release rates in LPS-contaminated dentin.
Article
Multidisciplinary Sciences
Ahmed Abdelaal, Salaheldin Elkatatny, Abdulazeez Abdulraheem
Summary: Two models were developed using artificial neural networks and adaptive neuro-fuzzy inference system to estimate formation pressure gradient in real-time through drilling data. The models showed good accuracy in predicting pressure gradient, proving their reliability.
SCIENTIFIC REPORTS
(2022)
Review
Polymer Science
Gustavo A. Rico-Llanos, Sara Borrego-Gonzalez, Miguelangel Moncayo-Donoso, Jose Becerra, Rick Visser
Summary: Collagen type I is widely used in bone tissue engineering due to its excellent biocompatibility and osteoconductivity, but it also has drawbacks such as high biodegradability and low mechanical strength. Recent efforts have been focused on designing and producing collagen implants to enhance bone regeneration.
Article
Biotechnology & Applied Microbiology
Paola Nitti, Sanosh Kunjalukkal Padmanabhan, Serena Cortazzi, Eleonora Stanca, Luisa Siculella, Antonio Licciulli, Christian Demitri
Summary: In this study, composite structures made of hydroxyapatite scaffold impregnated with a collagen slurry were designed to mimic bone tissue structure, with the addition of magnesium and silicon ions enhancing mechanical and biological properties. An innovative freeze-drying approach was developed to create open-pore structures for tissue regeneration. The biodegradation behavior of the scaffolds, particularly HA-Mg_Coll scaffolds, showed moderate weight loss and mechanical performance reduction due to collagen dissolution, while also protecting the ceramic structure until degradation, making them suitable candidates for bone remodeling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Mojtaba Jazayeri, Sadegh Mohsenzade, Javad Naghibi, Kamyar Mehran
Summary: This article proposes a real-time CM technique for assessing the level of IGBT gate oxide degradation. By capturing the device turn-OFF delay time and converting it to a dc voltage output, the health status of the IGBT gate oxide layer can be effectively evaluated.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Review
Orthopedics
Justin E. Hellwinkel, Zachary M. Working, Laura Certain, Andres J. Garcia, Joseph C. Wenke, Chelsea S. Bahney
Summary: Infection is a common cause of impaired fracture healing, and the current approach of treating fractures and infections separately can be costly and result in more procedures and patient morbidity. Bringing together scientists and engineers to develop new therapies that address both infection and fracture healing is essential. This article highlights the need for collaboration and research into the challenges posed by delayed fracture healing due to infection.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Engineering, Biomedical
Vitalij Novickij, Austeja Baleviciute, Veronika Malysko, Augustinas Zelvys, Eivina Radzeviciute, Bor Kos, Aukse Zinkeviciene, Damijan Miklavcic, Jurij Novickij, Irute Girkontaite
Summary: This study focuses on the use of high repetition frequency unipolar nanosecond pulses for bleomycin electrochemotherapy. It was found that the efficacy of sub-microsecond electrochemotherapy can be manipulated solely by the time delay between pulses.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Oncology
Paulius Ruzgys, Diana Navickaite, Ruta Palepsiene, Dovile Uzdavinyte, Neringa Barauskaite, Vitalij Novickij, Irute Girkontaite, Brigita Sitkauskiene, Saulius Satkauskas
Summary: This study shows that intracellular delivery of calcium ions and anticancer drug bleomycin not only kills the cells but also has a negative bystander effect on indirectly treated cells. These treatments are effective on directly treated tumors but have little effect on distal nodules. Combination with other methods is needed for the treatment of distal nodules.
Article
Pharmacology & Pharmacy
Eivina Radzeviciute, Veronika Malysko-Ptasinske, Jurij Novickij, Vitalij Novickij, Irute Girkontaite
Summary: In this study, the researchers transferred protein-encoding plasmids into different types of cells using sub-microsecond pulsed electric fields. They found that nanosecond pulses resulted in higher transfection efficiency, and the size and concentration of the plasmids also affected the transfection efficiency. Additionally, there was no significant difference in transfection efficiency between immature and mature immune cells.
Article
Orthopedics
Michael Mullen, Katherine Williams, Tom LaRocca, Victoria Duke, William S. Hambright, Sudheer K. Ravuri, Chelsea S. Bahney, Nicole Ehrhart, Johnny Huard
Summary: The secretome of mesenchymal stem cells (MSCs) has a regenerative potential in the absence of the cells themselves, with exosomes being a promising component. This study found that mechanical strain increased exosome production from muscle progenitor cells and could be regulated with different tensile loading regimens. Exosomes from mechanically stimulated cells enhanced proliferation and myogenic differentiation of naïve muscle cells. Additionally, the content of exosomal miRNA was differentially expressed following strain, suggesting potential mechanisms responsible for the proregenerative effects.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Eivina Radzeviciute, Veronika Malysko-Ptasinske, Julita Kulbacka, Nina Rembialkowska, Jurij Novickij, Irute Girkontaite, Vitalij Novickij
Summary: This study proposes nanosecond electrochemotherapy protocols that are as effective as the conventional method, showing potential as an alternative treatment for lung cancer cells.
BIOELECTROCHEMISTRY
(2022)
Article
Neurosciences
Susan Sienko, Cathleen Buckon, Anita Bagley, Eileen Fowler, Kent Heberer, Loretta Staudt, Mitell Sison-Williamson, Craig McDonald, Michael Sussman
Summary: The aim of this study was to examine the sensitivity of Gait Deviation Index (GDI) and Movement Analysis Profile (Gait Profile Score (GPS) and Gait Variable Score (GVS)) in quantifying longitudinal ambulatory decline in boys with Duchenne Muscular Dystrophy (DMD). The results showed that GDI and GPS indices were able to identify changes in the quality of gait patterns in boys with DMD. Boys who were steroid naive had a faster decline in gait quality compared to boys on corticosteroid treatment.
Review
Orthopedics
K. Yamaura, A. L. Nelson, H. Nishimura, J. C. Rutledge, S. K. Ravuri, C. Bahney, M. J. Philippon, J. Huard
Summary: The objective of this study was to analyze the latest evidence on the effects of losartan or Ang II receptor antagonists on cartilage repair, with a focus on their clinical relevance. The effects of losartan or Ang II receptor antagonists on cartilage repair in in vitro and in vivo animal studies were evaluated. A total of 12 studies were included in this systematic review, and qualitative evaluation was conducted for each study due to the difficulty of meta-analysis. Both in vitro and in vivo studies provide evidence to demonstrate the beneficial effects of Ang II receptor antagonists on osteoarthritis and cartilage defect models across animal species.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Oncology
Austeja Baleviciute, Eivina Radzeviciute, Augustinas Zelvys, Veronika Malysko-Ptasinske, Jurij Novickij, Aukse Zinkeviciene, Vytautas Kaseta, Vitalij Novickij, Irute Girkontaite
Summary: Standard microsecond electrochemotherapy (mu sECT) is widely used for tumor elimination, while the research on nanosecond electrochemotherapy (nsECT) is relatively recent. This study investigates the response of the immune system to nsECT and demonstrates its effectiveness in tumor elimination and improvement of survival rate in mice. The study also observes significant changes in the immune system after electrochemotherapy treatment.
Article
Biology
Robert A. A. Waltz, Kaitlyn E. E. Whitney, Victoria R. R. Duke, Heidi Kloser, Charles Huard, Matthew T. T. Provencher, Marc J. J. Philippon, Chelsea Bahney, Jonathan A. A. Godin, Johnny Huard
Summary: This study aims to prospectively analyze senescent cells in synovial fluid and peripheral blood of patients with an acute knee injury within 48 hours. It was found that senescent cells were present in both synovial fluid and peripheral blood of patients with acute ACL tear with effusion. Senescent-associated factors were significantly higher in synovial fluid, while regenerative factors were significantly higher in blood serum.
Article
Endocrinology & Metabolism
Ricki S. Carroll, Robert C. Olney, Angela L. Duker, Ryan F. Coghlan, William G. Mackenzie, Colleen P. Ditro, Cassondra J. Brown, David A. O'Connell, William A. Horton, Brian Johnstone, Eric A. Espiner, Timothy C. R. Prickett, Michael B. Bober
Summary: This study aimed to measure the levels of collagen X marker (CXM) in patients with dwarfism caused by FGFR3-opathies. The results showed that children with achondroplasia had significantly decreased levels of CXM compared to the control group, and the temporal patterns of change in CXM levels were dependent on sex.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Review
Clinical Neurology
Jimmy Tat, Jessica Tat, Samuel Yoon, Albert J. M. Yee, Jeremie Larouche
Summary: This study is a systematic review on the use of intraoperative ultrasound (IOUS) in spine decompression surgery. The review found that IOUS is useful in decompression surgery for degenerative cases and fractures in all regions of the spine. However, there is still no universal definition for adequate decompression using IOUS.
