Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Selective drug delivery approaches to lesioned brain through blood brain barrier disruption

(2018) Zahraa S. Al-Ahmady   Expert Opinion on Drug Delivery

The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [18F]FDDNP PET

(2018) Graham B. Cole et al.   MOLECULAR IMAGING AND BIOLOGY

Structural biology of solute carrier (SLC) membrane transport proteins

(2018) Xiaoyun Bai et al.   MOLECULAR MEMBRANE BIOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Preliminary experience with a transcranial magnetic resonance–guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson’s disease

(2018) Domenico Gerardo Iacopino et al.   Neurosurgical Focus

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

(2018) Mariafrancesca Scalise et al.   Frontiers in Chemistry

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Rationalizing Steroid Interactions with Lipid Membranes: Conformations, Partitioning, and Kinetics

(2018) Kalina Atkovska et al.   ACS Central Science

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease

(2017) J Scott Miners et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

P2.03b-012 A Phase II Study of Etirinotecan Pegol (NKTR-102) in Patients with Refractory Brain Metastases and Advanced Lung Cancer

(2017) Seema Nagpal et al.   Journal of Thoracic Oncology

Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI

(2017) Harm J. van de Haar et al.   MEDICAL PHYSICS

Targeting the Central Nervous System (CNS): A Review of Rabies Virus-Targeting Strategies

(2017) Mira Oswald et al.   MOLECULAR PHARMACEUTICS

ATIM-17. EARLY RESULTS OF A MULTICENTER PHASE I AND OPEN-LABEL, RANDOMIZED PHASE II STUDY TESTING THE TOXICITIES AND EFFICACY OF MK-3475 (PEMBROLIZUMAB) IN COMBINATION WITH MRI-GUIDED LASER INTERSTITIAL THERMAL THERAPY (LITT) IN RECURRENT MALIGNANT GLIOMAS

(2017) Jian Campian et al.   NEURO-ONCOLOGY

The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications

(2017) Yiming Lei et al.   PROGRESS IN NEUROBIOLOGY

Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy

(2017) Hima Bindu Ruttala et al.   Oncotarget

Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective

(2017) Zhenjie Wang et al.   Asian Journal of Pharmaceutical Sciences

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

(2016) Axel Montagne et al.   ACTA NEUROPATHOLOGICA

Cortical Perfusion Alteration in Normal-Appearing Gray Matter Is Most Sensitive to Disease Progression in Relapsing-Remitting Multiple Sclerosis

(2016) S.- P. Hojjat et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Combined defects in oxidative phosphorylation and fatty acid  -oxidation in mitochondrial disease

(2016) A. Nsiah-Sefaa et al.   BIOSCIENCE REPORTS

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

(2016) David S. Hersh et al.   CURRENT PHARMACEUTICAL DESIGN

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Concepts, technologies, and practices for drug delivery past the blood–brain barrier to the central nervous system

(2016) Lindsey Crawford et al.   JOURNAL OF CONTROLLED RELEASE

The potential use of rabies virus glycoprotein-derived peptides to facilitate drug delivery into the central nervous system: a mini review

(2016) Rachel Huey et al.   JOURNAL OF DRUG TARGETING

Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

(2016) U. Vazana et al.   JOURNAL OF NEUROSCIENCE

Analysis of the Applicability and Use of Lipinski`s Rule for Central Nervous System Drugs

(2016) Thais B. Fernandes et al.   Letters in Drug Design & Discovery

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study

(2016) Kathleen F Pirollo et al.   MOLECULAR THERAPY

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

NS-14A PILOT STUDY OF USING MRI-GUIDED LASER HEAT ABLATION TO INDUCE DISRUPTION OF THE PERITUMORAL BLOOD BRAIN BARRIER TO ENHANCE DELIVERY AND EFFICACY OF TREATMENT OF PEDIATRIC BRAIN TUMORS

(2016) Karen Gauvain et al.   NEURO-ONCOLOGY

OS7.2 A Phase II Study of ANG1005, a novel BBB/BCB Penetratant Taxane in Patients with Recurrent Brain Metastases and Leptomeningeal Carcinomatosis from Breast Cancer

(2016) P. Kumthekar et al.   NEURO-ONCOLOGY

Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging

(2016) Harm J. van de Haar et al.   NEUROBIOLOGY OF AGING

Ayub Khan Ommaya (1930-2008): Legacy and Contributions to Neurosurgery

(2016) Rimal Hanif Dossani et al.   NEUROSURGERY

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Chromatography-free synthesis of monodisperse oligo(ethylene glycol) mono-p-toluenesulfonates and quantitative analysis of oligomer purity

(2016) Adam M. Wawro et al.   Polymer Chemistry

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

(2015) Mitchel J. R. Ruigrok et al.   AAPS Journal

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood-brain barrier

(2015) KE Parrish et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Arterial spin labeling imaging reveals widespread and Aβ-independent reductions in cerebral blood flow in elderly apolipoprotein epsilon-4 carriers

(2015) Lars Michels et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease

(2015) Ilse S. Pienaar et al.   NEUROBIOLOGY OF DISEASE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and18F-FDG PET Quantitative Analysis Using FreeSurfer

(2015) Matthieu Bailly et al.   Biomed Research International

Mitochondrial Dysfunction in Parkinson's Disease

(2015) Hyo Eun Moon et al.   Experimental Neurobiology

Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system

(2014) Muna Aryal et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

(2014) Bradley Croy Doak et al.   CHEMISTRY & BIOLOGY

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

A new angle on blood-CNS interfaces: A role for connexins?

(2014) Marijke De Bock et al.   FEBS LETTERS

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tat 101-Mediated Enhancement of Brain Pericyte Migration Involves Platelet-Derived Growth Factor Subunit B Homodimer: Implications for Human Immunodeficiency Virus-Associated Neurocognitive Disorders

(2014) F. Niu et al.   JOURNAL OF NEUROSCIENCE

Activity of P-Glycoprotein, a  -Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

(2014) A. K. Deo et al.   JOURNAL OF NUCLEAR MEDICINE

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)

(2014) Sophie Le Trionnaire et al.   MedChemComm

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

Focal hemosiderin deposits and β-amyloid load in the ADNI cohort

(2013) Kejal Kantarci et al.   Alzheimers & Dementia

Phase I Study of GRN1005 in Recurrent Malignant Glioma

(2013) J. Drappatz et al.   CLINICAL CANCER RESEARCH

Cell-Penetrating Peptide-Mediated Therapeutic Molecule Delivery into the Central Nervous System

(2013) Li-Li Zou et al.   Current Neuropharmacology

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Randomized trial of safinamide add-on to levodopa in Parkinson's disease with motor fluctuations

(2013) Rupam Borgohain et al.   MOVEMENT DISORDERS

Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid

(2013) Ruth Mokgokong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Targeted Delivery of Nano-Therapeutics for Major Disorders of the Central Nervous System

(2013) Huile Gao et al.   PHARMACEUTICAL RESEARCH

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

(2013) E. G. Geier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Xentry, a new class of cell-penetrating peptide uniquely equipped for delivery of drugs

(2013) Kristopher Montrose et al.   Scientific Reports

Erythropoietin

(2013) H. F. Bunn   Cold Spring Harbor Perspectives in Medicine

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

(2013) Sarah L. DeVos et al.   Jove-Journal of Visualized Experiments

Abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI

(2013) S.P. Cramer et al.   NeuroImage-Clinical

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

(2012) Ethan A. Winkler et al.   ACTA NEUROPATHOLOGICA

Widespread cerebral haemodynamics disturbances occur early in amyotrophic lateral sclerosis

(2012) Matthew J. Murphy et al.   Amyotrophic Lateral Sclerosis

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma

(2012) J. L. Rubenstein et al.   BLOOD

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Impaired blood–brain/spinal cord barrier in ALS patients

(2012) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

Overview of P-glycoprotein inhibitors: a rational outlook

(2012) Kale Mohana Raghava Srivalli et al.   Brazilian Journal of Pharmaceutical Sciences

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

(2012) Natalia Penner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Tight Junction in Blood-Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

(2012) Wei-Ye Liu et al.   CNS Neuroscience & Therapeutics

Quantification of Perfusion and Permeability in Multiple Sclerosis

(2012) Michael Ingrisch et al.   INVESTIGATIVE RADIOLOGY

Nasal drug delivery — Recent developments and future prospects

(2012) Lisbeth Illum   JOURNAL OF CONTROLLED RELEASE

The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy

(2012) Stavros J. Baloyannis et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Confounding Parameters in Preclinical Assessment of Blood–Brain Barrier Permeation: An Overview With Emphasis on Species Differences and Effect of Disease States

(2012) Anand K. Deo et al.   MOLECULAR PHARMACEUTICS

Targeted and Reversible Blood-Retinal Barrier Disruption via Focused Ultrasound and Microbubbles

(2012) Juyoung Park et al.   PLoS One

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

(2012) Hillary D. Protas et al.   JAMA Neurology

Modern methods for delivery of drugs across the blood–brain barrier

(2011) Yan Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease

(2011) T. R. Melzer et al.   BRAIN

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

(2011) Daniëlle M. E. van Assema et al.   BRAIN

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

(2011) Kazunori Miyazaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Quantitative Membrane Protein Expression at the Blood–Brain Barrier of Adult and Younger Cynomolgus Monkeys

(2011) Katsuaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Complex relationships between cerebral blood flow and brain atrophy in early Huntington's disease

(2011) J. Jean Chen et al.   NEUROIMAGE

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Multidrug resistance associated proteins in multidrug resistance

(2011) Kamlesh Sodani et al.   Chinese Journal of Cancer

Regiospecific and conformationally restrained analogs of melphalan and dl-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood–brain barrier

(2010) Jyothi Matharu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroprotection in stroke in the mouse with intravenous erythropoietin–Trojan horse fusion protein

(2010) Ailing Fu et al.   BRAIN RESEARCH

Inflammatory Pain Signals an Increase in Functional Expression of Organic Anion Transporting Polypeptide 1a4 at the Blood-Brain Barrier

(2010) P. T. Ronaldson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Drug Targeting of Erythropoietin Across the Primate Blood-Brain Barrier with an IgG Molecular Trojan Horse

(2010) R. J. Boado et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping

(2010) Saeid Taheri et al.   MAGNETIC RESONANCE IN MEDICINE

Gray matter perfusion correlates with disease severity in ALS

(2010) R. R. Rule et al.   NEUROLOGY

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Transcranial Magnetic Resonance Imaging– Guided Focused Ultrasound Surgery of Brain Tumors

(2010) Nathan McDannold et al.   NEUROSURGERY

Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

(2009) Lichen Yin et al.   BIOMATERIALS

RNOP-09: Pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma - a phase II study

(2009) Christoph P Beier et al.   BMC CANCER

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease

(2009) Lisa Mosconi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The cell biology of rabies virus: using stealth to reach the brain

(2009) Matthias J. Schnell et al.   NATURE REVIEWS MICROBIOLOGY

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

(2009) Susan M. Landau et al.   NEUROBIOLOGY OF AGING

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

(2009) J. S. Henkel et al.   NEUROLOGY

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

Intracerebroventricular Administration of Drugs

(2009) Aaron M Cook et al.   PHARMACOTHERAPY

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

(2008) Masaru Yamamoto et al.   AMERICAN JOURNAL OF PATHOLOGY

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Brain endothelial cells and the glio-vascular complex

(2008) Hartwig Wolburg et al.   CELL AND TISSUE RESEARCH

Blood-Brain Barrier and Feeding: Regulatory Roles of Saturable Transport Systems for Ingestive Peptides

(2008) Abba Kastin et al.   CURRENT PHARMACEUTICAL DESIGN

Do enthalpy and entropy distinguish first in class from best in class?

(2008) E FREIRE   DRUG DISCOVERY TODAY

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

(2008) S. Syvanen et al.   DRUG METABOLISM AND DISPOSITION

Concepts in the pathogenesis of rabies

(2008) Bernhard Dietzschold et al.   Future Virology

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Peripheral Nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells

(2008) Fumitaka Shimizu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

(2008) Michel Demeule et al.   JOURNAL OF NEUROCHEMISTRY

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

(2008) Junichi Kamiie et al.   PHARMACEUTICAL RESEARCH

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

Barriers in the brain: a renaissance?

(2008) Norman R. Saunders et al.   TRENDS IN NEUROSCIENCES

Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

(2008) Nickolai Sheikov et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat

(2003) Torben Moos et al.   JOURNAL OF NEUROCHEMISTRY