The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)
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Title
The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)
Authors
Keywords
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Journal
MedChemComm
Volume 5, Issue 6, Pages 728-736
Publisher
Royal Society of Chemistry (RSC)
Online
2014-04-07
DOI
10.1039/c3md00323j
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- (2015) Madhav Lavu et al. CLINICAL SCIENCE
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- (2014) Bindu D. Paul et al. NATURE
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- (2014) Miriam M. Cortese-Krott et al. Redox Biology
- Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe
- (2013) Megan K. Thorson et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Cystathionine γ-Lyase Deficiency Protects Mice from Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure
- (2013) Kazuhiro Shirozu et al. ANTIOXIDANTS & REDOX SIGNALING
- Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway
- (2013) Katalin Módis et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
- (2013) Takuya Watanabe et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Prostaglandin E2-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd.3 brain endothelial cells
- (2013) Tae Yeop Park et al. BRITISH JOURNAL OF PHARMACOLOGY
- The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E−/−mice
- (2013) Zhen Liu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia
- (2013) Keqing Wang et al. CIRCULATION
- H 2 S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase
- (2013) Kazuhisa Kondo et al. CIRCULATION
- Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis
- (2013) Sarathi Mani et al. CIRCULATION
- A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury
- (2013) Michela Campolo et al. FASEB JOURNAL
- The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells
- (2013) Ling Li et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
- (2013) C. Szabo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxygen-sensitive mitochondrial accumulation of cystathionine -synthase mediated by Lon protease
- (2013) H. Teng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues
- (2012) Bifeng Chen et al. ANALYST
- Hydrogen Sulfide: A Rescue Molecule for Mucosal Defence and Repair
- (2012) John L. Wallace DIGESTIVE DISEASES AND SCIENCES
- Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
- (2012) Katalin Módis et al. FASEB JOURNAL
- Hydrogen sulfide: a gasotransmitter of clinical relevance
- (2012) M. Scott Vandiver et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model
- (2012) Sumio Ohtsuki et al. MOLECULAR PHARMACEUTICS
- Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes
- (2012) Stefania Merighi et al. PHARMACOLOGICAL RESEARCH
- A New Slow Releasing, H2S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium
- (2012) Hayley Robinson et al. PLoS One
- Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production
- (2012) M. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial pharmacology
- (2012) Robin A.J. Smith et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells
- (2011) Mark M. Perry et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Capture and Visualization of Hydrogen Sulfide by a Fluorescent Probe
- (2011) Chunrong Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools
- (2011) Matthew Whiteman et al. CLINICAL SCIENCE
- Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage—implications for the treatment of osteoporosis
- (2011) Zhong-Shi Xu et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2011) Bridget Fox et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function
- (2011) K. Suzuki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hydrogen sulfide protects against vascular remodeling from endothelial damage
- (2010) Thomas P. Vacek et al. AMINO ACIDS
- Molecular Cytogenetic Characterization of the Human Cerebral Microvessel Endothelial Cell Line hCMEC/D3
- (2010) H. Mkrtchyan et al. CYTOGENETIC AND GENOME RESEARCH
- Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide
- (2010) M. Whiteman et al. DIABETOLOGIA
- Synthesis and Biological Effects of Hydrogen Sulfide (H2S): Development of H2S-Releasing Drugs as Pharmaceuticals
- (2010) Giuseppe Caliendo et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2009) Matthew Whiteman et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2009) Matthew Whiteman et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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- (2009) Wei-Lan Yin et al. LIFE SCIENCES
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- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)
- (2008) Ling Li et al. CIRCULATION
- H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine -Lyase
- (2008) G. Yang et al. SCIENCE
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