Fungal proteinaceous compounds with multiple biological activities

Biological and antipathogenic activities of ribosome-inactivating proteins from Phytolacca dioica L.

(2016) Rosario Iglesias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

tRNA-targeting ribonucleases: molecular mechanisms and insights into their physiological roles

(2016) Tetsuhiro Ogawa   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities

(2016) Xin Meng et al.   CARBOHYDRATE RESEARCH

Expression of a Tandemly Arrayed Plectasin Gene from Pseudoplectania nigrella in Pichia pastoris and its Antimicrobial Activity

(2016) Jin Wan et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Two Chitotriose-Specific Lectins Show Anti-Angiogenesis, Induces Caspase-9-Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle

(2016) Ruby Singh et al.   PLoS One

Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research

(2015) Ouafae Akkouh et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular chaperones (TrxA, SUMO, Intein, and GST) mediating expression, purification, and antimicrobial activity assays of plectasin inEscherichia coli

(2015) Xin Chen et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Optimization of expression conditions for a novel NZ2114-derived antimicrobial peptide-MP1102 under the control of the GAP promoter in Pichia pastoris X-33

(2015) Ruoyu Mao et al.   BMC MICROBIOLOGY

Macrocyclic trichothecenes as antifungal and anticancer compounds

(2015) Maira de Carvalho et al.   CURRENT MEDICINAL CHEMISTRY

Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

(2015) Jorrit Jeroen Water et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Molecular mechanism of anticancer effect ofSclerotium rolfsiilectin in HT29 cells involves differential expression of genes associated with multiple signaling pathways: A microarray analysis

(2015) Srikanth Barkeer et al.   GLYCOBIOLOGY

Polysaccharide K and Coriolus versicolor Extracts for Lung Cancer

(2015) Heidi Fritz et al.   INTEGRATIVE CANCER THERAPIES

Ribotoxin restrictocin manifests anti-HIV-1 activity through its specific ribonuclease activity

(2015) Santosh K. Yadav et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium

(2015) Hui-Yeng Y. Yap et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification and Characterization of an Antifungal Protein, AfAFPR9, Produced by Marine-Derived Aspergillus fumigatus R9

(2015) Qi Rao et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The Stability, and Efficacy Against Penicillin-Resistant Enterococcus faecium, of the Plectasin Peptide Efficiently Produced by Escherichia coli

(2015) Xin Chen et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Snake venom galactoside-binding lectins: a structural and functional overview

(2015) Marco A. Sartim et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Antimicrobial Activity of Plectasin NZ2114 in Combination with Cell Wall Targeting Antibiotics Against VanA-TypeEnterococcus faecalis

(2015) Elena B.M. Breidenstein et al.   Microbial Drug Resistance

Antifungal activity of the ribosome-inactivating protein BE27 from sugar beet (Beta vulgaris L.) against the green mouldPenicillium digitatum

(2015) Lucía Citores et al.   MOLECULAR PLANT PATHOLOGY

Insights into Animal and Plant Lectins with Antimicrobial Activities

(2015) Renata Dias et al.   MOLECULES

Cysteine-stabilized αβ defensins: From a common fold to antibacterial activity

(2015) Renata de Oliveira Dias et al.   PEPTIDES

Plectasin, First Animal Toxin-Like Fungal Defensin Blocking Potassium Channels through Recognizing Channel Pore Region

(2015) Fang Xiang et al.   Toxins

Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts

(2015) Jaime Tomé-Amat et al.   SpringerPlus

Combinations of β-Lactam or Aminoglycoside Antibiotics with Plectasin Are Synergistic against Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus

(2015) Yanmin Hu et al.   PLoS One

Design and recombination expression of a novel plectasin-derived peptide MP1106 and its properties against Staphylococcus aureus

(2014) Xintao Cao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells

(2014) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

X-Ray Crystallographic Structure of RNase Po1 That Exhibits Anti-tumor Activity

(2014) Hiroko Kobayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mechanism of action of the tri-hybrid antimicrobial peptide LHP7 from lactoferricin, HP and plectasin on Staphylococcus aureus

(2014) Di Xi et al.   BIOMETALS

Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 fromHericium erinaceuson inhibition of human leukemia cell line proliferation

(2014) Hiroko Kobayashi et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin

(2014) C. Yin et al.   CURRENT MOLECULAR MEDICINE

First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa)

(2014) Chang Rong Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Copsin, a Novel Peptide-based Fungal Antibiotic Interfering with the Peptidoglycan Synthesis

(2014) Andreas Essig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Fusion of Protegrin-1 and Plectasin to MAP30 Shows Significant Inhibition Activity against Dengue Virus Replication

(2014) Hussin A. Rothan et al.   PLoS One

Current progress in antiviral strategies

(2014) Zhiyong Lou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Novel Laccase with Potent Antiproliferative and HIV-1 Reverse Transcriptase Inhibitory Activities from Mycelia of MushroomCoprinus comatus

(2014) Shuang Zhao et al.   Biomed Research International

A new strategy to fight antimicrobial resistance: the revival of old antibiotics

(2014) Nadim Cassir et al.   Frontiers in Microbiology

β -Glucans and their Applications in Cancer Therapy: Focus on human studies

(2013) Eiman Aleem   Anti-Cancer Agents in Medicinal Chemistry

High expression of a plectasin-derived peptide NZ2114 in Pichia pastoris and its pharmacodynamics, postantibiotic and synergy against Staphylococcus aureus

(2013) Yong Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A novel ribonuclease with antiproliferative activity toward leukemia and lymphoma cells and HIV-1 reverse transcriptase inhibitory activity from the mushroom, Hohenbuehelia serotina

(2013) RUI ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Interruption of Lung Cancer Cell Migration and Proliferation by Fungal Immunomodulatory Protein FIP-fve from Flammulina velutipes

(2013) Yu-Chi Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antiviral Cationic Peptides as a Strategy for Innovation in Global Health Therapeutics for Dengue Virus: High Yield Production of the Biologically Active Recombinant Plectasin Peptide

(2013) Hussin A. Rothan et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Rhizoctonia Bataticola Lectin (RBL) Induces Caspase-8-Mediated Apoptosis in Human T-Cell Leukemia Cell Lines but Not in Normal CD3 and CD34 Positive Cells

(2013) Radha Pujari et al.   PLoS One

Ribosome-inactivating proteins: From toxins to useful proteins

(2013) Fiorenzo Stirpe   TOXICON

New antibiotics for bad bugs: where are we?

(2013) Matteo Bassetti et al.   Annals of Clinical Microbiology and Antimicrobials

New Bioactive Fungal Molecules with High Antioxidant and Antimicrobial Capacity Isolated fromCerrena unicolorIdiophasic Cultures

(2013) Magdalena Jaszek et al.   Biomed Research International

Crystallization and preliminary X-ray crystallographic analysis of the small subunit of the heterodimeric laccase POXA3b fromPleurotus ostreatus

(2013) Marta Ferraroni et al.   Acta Crystallographica Section F-Structural Biology Communications

Design, expression, and characterization of a novel targeted plectasin against methicillin-resistant Staphylococcus aureus

(2012) Ruoyu Mao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Differential inhibitory potencies and mechanisms of the type I ribosome inactivating protein marmorin on estrogen receptor (ER)-positive and ER-negative breast cancer cells

(2012) Wen Liang Pan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Novel Aspartic Protease with HIV-1 Reverse Transcriptase Inhibitory Activity from Fresh Fruiting Bodies of the Wild MushroomXylaria hypoxylon

(2012) Qing-Xiu Hu et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A Laccase with Antiproliferative and HIV-I Reverse Transcriptase Inhibitory Activities from the Mycorrhizal FungusAgaricus placomyces

(2012) Jian Sun et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Molecular docking and dynamics simulations of A.niger RNase from Aspergillus niger ATCC26550: for potential prevention of human cancer

(2012) Gundampati Ravi Kumar et al.   JOURNAL OF MOLECULAR MODELING

A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

(2012) Maria Alves et al.   PLANTA MEDICA

Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin  -sarcin

(2012) N. Carreras-Sangra et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Efficacy of NZ2114, a Novel Plectasin-Derived Cationic Antimicrobial Peptide Antibiotic, in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

(2011) Yan Q. Xiong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Primary Structure and Specificity of a New Member of Galectin Family from the Amethyst Deceiver MushroomLaccaria amethystina

(2011) Beatrice LYIMO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Bioactive proteins from mushrooms

(2011) Xiaofei Xu et al.   BIOTECHNOLOGY ADVANCES

Purification and characterization of a lectin with antiproliferative activity toward cancer cells from the dried fruit bodies of Lactarius flavidulus

(2011) Yingying Wu et al.   CARBOHYDRATE RESEARCH

Identification of a haemolysin-like peptide with antibacterial activity using the draft genome sequence ofStaphylococcus epidermidisstrain A487

(2011) Mohammed M. Al-Mahrous et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

An Antifungal Protein from the Culinary-Medicinal Beech Mushroom, Hypsizygus marmoreus (Peck) Bigel. (Agaricomycetideae)

(2011) Tomohiro Suzuki et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Purification and characterization of a novel RNase with antiproliferative activity from the mushroom Lactarius flavidulus

(2011) Yingying Wu et al.   JOURNAL OF ANTIBIOTICS

Cordysobin, a novel alkaline serine protease with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Cordyceps sobolifera

(2011) Shou-Xian Wang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Protein-protein docking on molecular models of Aspergillus niger RNase and human actin: novel target for anticancer therapeutics

(2011) Ravi Kumar Gundampati et al.   JOURNAL OF MOLECULAR MODELING

An Evidence-Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient

(2011) Shinil K. Shah et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Bacterial-Fungal Interactions: Hyphens between Agricultural, Clinical, Environmental, and Food Microbiologists

(2011) P. Frey-Klett et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Antifungal action of human cathelicidin fragment (LL13–37) on Candida albicans

(2011) Jack Ho Wong et al.   PEPTIDES

Enhancement ofin vitroandin vivoanticancer activities of polysaccharide peptide fromGrifola frondosaby chemical modifications

(2011) Janet Yuen-Yan Chan et al.   PHARMACEUTICAL BIOLOGY

Expression of plectasin in Pichia pastoris and its characterization as a new antimicrobial peptide against Staphyloccocus and Streptococcus

(2011) Jun Zhang et al.   PROTEIN EXPRESSION AND PURIFICATION

Current findings, future trends, and unsolved problems in studies of medicinal mushrooms

(2010) Solomon P. Wasser   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The heme sensing response regulator HssR in Staphylococcus aureus but not the homologous RR23 in Listeria monocytogenes modulates susceptibility to the antimicrobial peptide plectasin

(2010) Line E Thomsen et al.   BMC MICROBIOLOGY

High-Level Expression of the Antimicrobial Peptide Plectasin in Escherichia coli

(2010) Xiao-Lan Jing et al.   CURRENT MICROBIOLOGY

A novel lectin with highly potent antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the edible wild mushroom Russula delica

(2010) Shuang Zhao et al.   GLYCOCONJUGATE JOURNAL

A Novel Lectin with Antiproliferative and HIV-1 Reverse Transcriptase Inhibitory Activities from Dried Fruiting Bodies of the Monkey Head MushroomHericium erinaceum

(2010) Yanrui Li et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Purification and characterization of a laccase from the edible wild mushroom Tricholoma mongolicum

(2010) Hexiang Wang   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris

(2010) Jack H. Wong et al.   PHYTOMEDICINE

Oyster Mushroom Laccase Inhibits Hepatitis C Virus Entry into Peripheral Blood Cells and Hepatoma Cells

(2010) Esmail M. EL-Fakharany et al.   PROTEIN AND PEPTIDE LETTERS

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

In Vivo Pharmacodynamic Characterization of a Novel Plectasin Antibiotic, NZ2114, in a Murine Infection Model

(2009) D. Andes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plectasin Shows Intracellular Activity against Staphylococcus aureus in Human THP-1 Monocytes and in a Mouse Peritonitis Model

(2009) K. S. Brinch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

alpha-Sarcin catalytic activity is not required for cytotoxicity

(2009) Spencer C Alford et al.   BMC BIOCHEMISTRY

Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris

(2009) Byung Tae Park et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Purification and characterization of a novel laccase from the edible mushroom Clitocybe maxima

(2009) Guo-Qing Zhang et al.   PROCESS BIOCHEMISTRY

Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods

(2009) Kalyaneswar Mandal et al.   PROTEIN SCIENCE

Marmorin, a new ribosome inactivating protein with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus

(2008) Jack H. Wong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Plectasin has antibacterial activity and no affect on cell viability or IL-8 production

(2008) Shintaro Hara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antimicrobial peptides effectively kill a broad spectrum of Listeria monocytogenes and Staphylococcus aureus strains independently of origin, sub-type, or virulence factor expression

(2008) Caroline Gottlieb et al.   BMC MICROBIOLOGY

Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese MushroomGanoderma colossum

(2008) Riham Salah El Dine et al.   JOURNAL OF NATURAL PRODUCTS

The insecticidal protein hirsutellin A from the mite fungal pathogenHirsutella thompsoniiis a ribotoxin

(2008) Elías Herrero-Galán et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus

(2007) Y.R. Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS