Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes

Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network

(2016) Yue-Yue Wang et al.   Scientific Reports

The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation

(2015) Yolanda Martínez-Burgo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

RSAT 2015: Regulatory Sequence Analysis Tools

(2015) Alejandra Medina-Rivera et al.   NUCLEIC ACIDS RESEARCH

Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies

(2014) Wenjie Du et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

DMINDA: an integrated web server for DNA motif identification and analyses

(2014) Qin Ma et al.   NUCLEIC ACIDS RESEARCH

A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877

(2014) Robert Bunet et al.   PLoS One

Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506)

(2013) Carlos Barreiro et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Transcriptomic Analysis of Streptomyces coelicolor Differentiation in Solid Sporulating Cultures: First Compartmentalized and Second Multinucleated Mycelia Have Different and Distinctive Transcriptomes

(2013) Paula Yagüe et al.   PLoS One

Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster

(2013) Adam C. Jones et al.   PLoS One

Roles offkbNin Positive Regulation andtcs7in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP

(2012) SangJoon Mo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Annotation of the Modular Polyketide Synthase and Nonribosomal Peptide Synthetase Gene Clusters in the Genome of Streptomyces tsukubaensis NRRL18488

(2012) Marko Blažič et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems

(2012) Dandan Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer ‘Streptomyces tsukubaensis’

(2012) Miriam Martínez-Castro et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

(2012) Dušan Goranovič et al.   BMC MICROBIOLOGY

A Walk into the LuxR Regulators of Actinobacteria: Phylogenomic Distribution and Functional Diversity

(2012) Catarina Lopes Santos et al.   PLoS One

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Functional conservation of PAS–LuxR transcriptional regulators in polyene macrolide biosynthesis

(2011) Javier Santos-Aberturas et al.   METABOLIC ENGINEERING

Novel chemobiosynthetic approach for exclusive production of FK506

(2011) Gregor Kosec et al.   METABOLIC ENGINEERING

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

(2011) J. N. Andexer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Control of Polyene Macrolide Biosynthesis

(2010) Javier Santos-Aberturas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

chipD: a web tool to design oligonucleotide probes for high-density tiling arrays

(2010) Y. S. Dufour et al.   NUCLEIC ACIDS RESEARCH

Impact of Topical Calcineurin Inhibitors on Quality of Life in Patients with Atopic Dermatitis

(2009) John R. Ingram et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Long-term safety of tacrolimus ointment in atopic dermatitis

(2009) Anita Remitz et al.   Expert Opinion On Drug Safety

Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon

(2009) Giselda Bucca et al.   GENOME BIOLOGY

Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation inPenicillium chrysogenum

(2008) Carlos García-Estrada et al.   BIOCHEMICAL JOURNAL

Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants

(2008) Germán Sierra-Paredes et al.   CNS Neuroscience & Therapeutics

Role of Phosphopantetheinyl Transferase Genes in Antibiotic Production by Streptomyces coelicolor

(2008) Y.-W. Lu et al.   JOURNAL OF BACTERIOLOGY