Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems

Toward Improvement of Erythromycin A Production in an Industrial Saccharopolyspora erythraea Strain via Facilitation of Genetic Manipulation with an ArtificialattBSite for Specific Recombination

(2011) Jiequn Wu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

(2011) Won Seok Jung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel chemobiosynthetic approach for exclusive production of FK506

(2011) Gregor Kosec et al.   METABOLIC ENGINEERING

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

(2011) J. N. Andexer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Regulation of tacrolimus production by altering primary source of carbons and amino acids

(2009) B.P. Singh et al.   LETTERS IN APPLIED MICROBIOLOGY

Identification and characterization of Streptomyces ghanaensis ATCC14672 integration sites for three actinophage-based plasmids

(2009) Bohdan Ostash et al.   PLASMID

Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants

(2008) Germán Sierra-Paredes et al.   CNS Neuroscience & Therapeutics