Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action

(2014) Chih-Wei Sheen et al.   BIOCHEMICAL JOURNAL

Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence

(2014) Grant D. Schauer et al.   NUCLEIC ACIDS RESEARCH

Fragment Screening by Weak Affinity Chromatography: Comparison with Established Techniques for Screening against HSP90

(2013) Elinor Meiby et al.   ANALYTICAL CHEMISTRY

Identification and Characterization of a Novel HIV-1 Nucleotide-Competing Reverse Transcriptase Inhibitor Series

(2013) D. Rajotte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening

(2013) Jonathan B. Baell et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Oral Antiretroviral Drugs as Public Health Tools for HIV Prevention: Global Implications for Adherence, Drug Resistance, and the Success of HIV Treatment Programs

(2013) Ravindra K. Gupta et al.   JOURNAL OF INFECTIOUS DISEASES

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening

(2013) Joseph D. Bauman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thermodynamics of HIV-1 Reverse Transcriptase in Action Elucidates the Mechanism of Action of Non-Nucleoside Inhibitors

(2013) Guillaume Bec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

(2013) H. L. Silvestre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies

(2011) Anthony K. Felts et al.   Journal of Chemical Information and Modeling

Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

(2011) Matthis Geitmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action

(2010) Séverine Freisz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antiretroviral Therapy in the Clinic

(2010) A. M. N. Tsibris et al.   JOURNAL OF VIROLOGY

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

(2009) Claudio Dalvit   DRUG DISCOVERY TODAY

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

(2008) Joseph D. Bauman et al.   NUCLEIC ACIDS RESEARCH

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase

(2008) Marie L. Coté et al.   VIRUS RESEARCH