Tackling drug resistance with efflux pump inhibitors: from bacteria to cancerous cells

Ursolic acid inhibits colistin efflux and curtails colistin resistant Enterobacteriaceae

(2019) Niranjana Sri Sundaramoorthy et al.   AMB Express

Aminoguanidine hydrazones (AGH's) as modulators of norfloxacin resistance in Staphylococcus aureus that overexpress NorA efflux pump

(2018) Natalina Dantas et al.   CHEMICO-BIOLOGICAL INTERACTIONS

OpuC – an ABC Transporter that is Associated with Staphylococcus Aureus Pathogenesis

(2018) Madanahally D. Kiran et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus

(2018) Santosh K. Rath et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer

(2018) Zhen Zhang et al.   BIOSCIENCE REPORTS

5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells

(2018) Sara Ranjbar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of the TetK efflux-pump by the essential oil of Chenopodium ambrosioides L. and α-terpinene against Staphylococcus aureus IS-58

(2017) Paulo W. Limaverde et al.   FOOD AND CHEMICAL TOXICOLOGY

The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition

(2017) Tapas Bhattacharyya et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Selective Targeting of Cancer Cells by Oxidative Vulnerabilities with Novel Curcumin Analogs

(2017) Christopher Pignanelli et al.   Scientific Reports

Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

(2017) Safiulla Basha Syed et al.   Scientific Reports

Dithiazole thione derivative as competitive NorA efflux pump inhibitor to curtail multi drug resistant clinical isolate of MRSA in a zebrafish infection model

(2016) Rene Christena Lowrence et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A role for ABCG2 beyond drug transport: Regulation of autophagy

(2016) Rui Ding et al.   Autophagy

The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies

(2016) Ewa Żesławska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Holarrhena antidysentericaExtract and Its Steroidal Alkaloid, Conessine, as Resistance-Modifying Agents Against Extensively Drug-ResistantAcinetobacter baumannii

(2016) Thanyaluck Siriyong et al.   Microbial Drug Resistance

Evaluation of the tannic acid inhibitory effect against the NorA efflux pump of Staphylococcus aureus

(2016) Saulo R. Tintino et al.   MICROBIAL PATHOGENESIS

Screening dietary flavonoids for the reversal of P-glycoprotein-mediated multidrug resistance in cancer

(2016) S. Mohana et al.   Molecular BioSystems

Identification of benzochromene derivatives as a highly specific NorA efflux pump inhibitor to mitigate the drug resistant strains of S. aureus

(2016) Asaithampi Ganesan et al.   RSC Advances

Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity

(2016) Ewa Otręebska-Machaj et al.   Frontiers in Microbiology

Targeted and controlled anticancer drug delivery and release with magnetoelectric nanoparticles

(2016) Alexandra Rodzinski et al.   Scientific Reports

Prediction of drug–ABC-transporter interaction — Recent advances and future challenges

(2015) Floriane Montanari et al.   ADVANCED DRUG DELIVERY REVIEWS

Icariin Enhances Cytotoxicity of Doxorubicin in Human Multidrug-Resistant Osteosarcoma Cells by Inhibition of ABCB1 and Down-Regulation of the PI3K/Akt Pathway

(2015) Zhendong Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Selective targeting of FAK–Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells

(2015) Amrita Datta et al.   CANCER LETTERS

Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy

(2015) Caroline M. Pule et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The overexpression of MRP4 is related to multidrug resistance in osteosarcoma cells

(2015) Feng Lin et al.   Journal of Cancer Research and Therapeutics

Multidrug-Resistance Transporter AbcA SecretesStaphylococcus aureusCytolytic Toxins

(2015) Hirono Yoshikai et al.   JOURNAL OF INFECTIOUS DISEASES

Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells

(2015) Xuelin Zhou et al.   JOURNAL OF NATURAL PRODUCTS

Combinatorial Activity of Flavonoids with Antibiotics Against Drug-ResistantStaphylococcus aureus

(2015) Ana Cristina Abreu et al.   Microbial Drug Resistance

Human ATP-Binding Cassette Transporter ABCB1 Confers Resistance to Volasertib (BI 6727), a Selective Inhibitor of Polo-like Kinase 1

(2015) Chung-Pu Wu et al.   MOLECULAR PHARMACEUTICS

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2)

(2015) Anita Kort et al.   PHARMACOLOGICAL RESEARCH

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

(2015) Diana Sousa et al.   TRENDS IN MOLECULAR MEDICINE

Structural basis for the blockade of MATE multidrug efflux pumps

(2015) Martha Radchenko et al.   Nature Communications

Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens

(2015) Lowrence Rene Christena et al.   RSC Advances

Copper nanoparticles as an efflux pump inhibitor to tackle drug resistant bacteria

(2015) Lowrence Rene Christena et al.   RSC Advances

Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

(2014) Qingcheng Mao et al.   AAPS Journal

Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae

(2014) Daniel Golparian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bifendate-chalcone hybrids: A new class of potential dual inhibitors of P-glycoprotein and breast cancer resistance protein

(2014) Xiaoke Gu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

(2014) Jingjing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925

(2014) X Yang et al.   BRITISH JOURNAL OF CANCER

Microvesicles mediate transfer of P-glycoprotein to paclitaxel-sensitive A2780 human ovarian cancer cells, conferring paclitaxel-resistance

(2014) Fang-fang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential contribution of AcrAB and OqxAB efflux pumps to multidrug resistance and virulence in Klebsiella pneumoniae

(2014) Suzanne Bialek-Davenet et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

High-level tetracycline resistance mediated by efflux pumps Tet(A) and Tet(A)-1 with two start codons

(2014) W. Wang et al.   JOURNAL OF MEDICAL MICROBIOLOGY

First Identification of Boronic Species as Novel Potential Inhibitors of the Staphylococcus aureus NorA Efflux Pump

(2014) Fanny Fontaine et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polyacrylic Acid-Coated Iron Oxide Nanoparticles for Targeting Drug Resistance in Mycobacteria

(2014) Priyanka Padwal et al.   LANGMUIR

Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2)

(2014) Kee W. Tan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines

(2014) Asma Kheirollahi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugs

(2014) Prashant Joshi et al.   MedChemComm

Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts

(2014) Shin-ya Morita et al.   Biomed Research International

Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump

(2014) Thelma Ohene-Agyei et al.   MicrobiologyOpen

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Nanomedicine therapeutic approaches to overcome cancer drug resistance

(2013) Janet L. Markman et al.   ADVANCED DRUG DELIVERY REVIEWS

Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos

(2013) Stephan Fischer et al.   BMC BIOLOGY

Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways

(2013) Lisa M. Willis et al.   CARBOHYDRATE RESEARCH

Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance

(2013) Joyce Gong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus

(2013) Winnie K.P. Shiu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

On the Origin of Large Flexibility of P-glycoprotein in the Inward-facing State

(2013) Po-Chao Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Re-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance

(2013) Stefano Sabatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Immunity to the Staphylococcus aureus leaderless four-peptide bacteriocin aureocin A70 is conferred by AurI, an integral membrane protein

(2013) Marcus Lívio Varella Coelho et al.   RESEARCH IN MICROBIOLOGY

Towards understanding promiscuity in multidrug efflux pumps

(2013) Kelvin Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates

(2012) Meenakshi Balganesh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ABC transporters and their role in nucleoside and nucleotide drug resistance

(2012) Yu Fukuda et al.   BIOCHEMICAL PHARMACOLOGY

Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance

(2012) Karthika Natarajan et al.   BIOCHEMICAL PHARMACOLOGY

Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

(2012) Jes Gitz Holler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Overview of P-glycoprotein inhibitors: a rational outlook

(2012) Kale Mohana Raghava Srivalli et al.   Brazilian Journal of Pharmaceutical Sciences

Investigational ABC transporter inhibitors

(2012) Marco Falasca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Inhibition of the Mycobacterium tuberculosis reserpine-sensitive efflux pump augments intracellular concentrations of ciprofloxacin and enhances susceptibility of some clinical isolates

(2012) Tsi-Shu Huang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Resistance to Paclitaxel in a Cisplatin-Resistant Ovarian Cancer Cell Line Is Mediated by P-Glycoprotein

(2012) Britta Stordal et al.   PLoS One

Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA

(2012) Jean Pierre Brincat et al.   ACS Medicinal Chemistry Letters

Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents

(2012) Michael Wink et al.   Frontiers in Microbiology

Increased Expression of P-Glycoprotein Is Associated with Doxorubicin Chemoresistance in the Metastatic 4T1 Breast Cancer Model

(2011) Lili Bao et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting the Multidrug ABCG2 Transporter with Flavonoidic Inhibitors: In Vitro Optimization and In Vivo Validation

(2011) A. Boumendjel et al.   CURRENT MEDICINAL CHEMISTRY

Amine–alkyl derivatives of hydantoin: New tool to combat resistant bacteria

(2011) Jadwiga Handzlik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microparticle-associated nucleic acids mediate trait dominance in cancer

(2011) Ritu Jaiswal et al.   FASEB JOURNAL

The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration

(2011) I. Leitner et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus

(2011) Z. M. Mirza et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of theS. aureusNorA Efflux Pump

(2011) Stefano Sabatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa

(2011) Momen Askoura et al.   Libyan Journal of Medicine

Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence

(2011) Joshua S. Klein et al.   Metallomics

Bacitracin and nisin resistance in Staphylococcus aureus: a novel pathway involving the BraS/BraR two-component system (SA2417/SA2418) and both the BraD/BraE and VraD/VraE ABC transporters

(2011) Aurélia Hiron et al.   MOLECULAR MICROBIOLOGY

Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells

(2011) Sen Li et al.   PHYTOMEDICINE

Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression

(2011) Takeo Nakanishi et al.   Chinese Journal of Cancer

Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters

(2010) Maciej Kaliszczak et al.   AAPS Journal

Rv1218c, an ABC Transporter of Mycobacterium tuberculosis with Implications in Drug Discovery

(2010) M. Balganesh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ABC Transporter AnrAB Contributes to the Innate Resistance of Listeria monocytogenes to Nisin, Bacitracin, and Various  -Lactam Antibiotics

(2010) B. Collins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

LmrS Is a Multidrug Efflux Pump of the Major Facilitator Superfamily from Staphylococcus aureus

(2010) J. L. Floyd et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Zhanglin Ni et al.   CURRENT DRUG METABOLISM

Drug Efflux Transporter Multidrug Resistance-Associated Protein 5 Affects Sensitivity of Pancreatic Cancer Cell Lines to the Nucleoside Anticancer Drug 5-Fluorouracil

(2010) P. K. Nambaru et al.   DRUG METABOLISM AND DISPOSITION

Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria

(2010) Mark I. Garvey et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae

(2010) Farid El Garch et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Regulation of MRP2/ABCC2 and BSEP/ABCB11 Expression in Sandwich Cultured Human and Rat Hepatocytes Exposed to Inflammatory Cytokines TNF-α, IL-6, and IL-1β

(2010) Lei Diao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the Ecs ABC Transporter of Staphylococcus aureus Attenuates Virulence by Altering Composition and Function of Bacterial Wall

(2010) Ing-Marie Jonsson et al.   PLoS One

Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin

(2009) Giovanni Luca Beretta et al.   BIOCHEMICAL PHARMACOLOGY

Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin

(2009) R. Beedholm-Ebsen et al.   BLOOD

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivoglioblastoma models

(2009) Ahcene Boumendjel et al.   BMC CANCER

A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen

(2009) Paul Ruff et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

(2009) Ogan Demir Abaan et al.   CANCER INVESTIGATION

Genetic Exchange of Multidrug Efflux Pumps among Two Enterobacterial Species with Distinctive Ecological Niches

(2009) Nehaya Al-Karablieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant Streptococcus pneumoniae Strains That Overexpress the ABC Transporters PatA and PatB

(2008) M. I. Garvey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli

(2008) F. Long et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multidrug Transport by the ABC Transporter Sav1866 fromStaphylococcus aureus†

(2008) Saroj Velamakanni et al.   BIOCHEMISTRY

Multidrug efflux transporters in the MATE family

(2008) Teruo Kuroda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps

(2008) Nadezhda German et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus

(2008) A. Kumar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The ABC-Type Multidrug Resistance Transporter LmrCD Is Responsible for an Extrusion-Based Mechanism of Bile Acid Resistance in Lactococcus lactis

(2008) A. H. Zaidi et al.   JOURNAL OF BACTERIOLOGY

NorB, an Efflux Pump in Staphylococcus aureus Strain MW2, Contributes to Bacterial Fitness in Abscesses

(2008) Y. Ding et al.   JOURNAL OF BACTERIOLOGY

Reversal of Drug Resistance in Ovarian Cancer: Where Do We Go From Here?

(2008) Stan B. Kaye   JOURNAL OF CLINICAL ONCOLOGY

Phase III Study of Valspodar (PSC 833) Combined With Paclitaxel and Carboplatin Compared With Paclitaxel and Carboplatin Alone in Patients With Stage IV or Suboptimally Debulked Stage III Epithelial Ovarian Cancer or Primary Peritoneal Cancer

(2008) Catherine Lhommé et al.   JOURNAL OF CLINICAL ONCOLOGY

From Phenothiazine to 3-Phenyl-1,4-benzothiazine Derivatives as Inhibitors of theStaphylococcus aureusNorA Multidrug Efflux Pump

(2008) Stefano Sabatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene

(2008) N. Abla et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The AcrAB-TolC Pump Is Involved in Multidrug Resistance in Clinical Shigella flexneri Isolates

(2008) Haiyan Yang et al.   Microbial Drug Resistance

Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

(2008) A. L. Davidson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Small multidrug resistance proteins: A multidrug transporter family that continues to grow

(2007) Denice C. Bay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Multidrug Transporter P-Glycoprotein: A Mediator of Melanoma Invasion?

(2007) Marisa Colone et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY