Investigational ABC transporter inhibitors

P-glycoprotein Inhibition: The Past, the Present and the Future

(2011) Richard A.J. Darby et al.   CURRENT DRUG METABOLISM

Novel Insights into Targeting ATP-Binding Cassette Transporters for Antitumor Therapy

(2011) L. Gatti et al.   CURRENT MEDICINAL CHEMISTRY

Advances in the Molecular Detection of ABC Transporters Involved in Multidrug Resistance in Cancer

(2011) Jean-Pierre Gillet et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy

(2011) Amit K. Tiwari et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux

(2011) Michelle J. Henderson et al.   JNCI-Journal of the National Cancer Institute

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of OATP1A and 1B transporters in vivo: insights from mouse models

(2011) Dilek Iusuf et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

(2010) R. J. Kelly et al.   CLINICAL CANCER RESEARCH

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

(2010) Robert A.B. van Waterschoot et al.   INTERNATIONAL JOURNAL OF CANCER

ABCG2: A potential marker of stem cells and novel target in stem cell and cancer therapy

(2010) Xi-wei Ding et al.   LIFE SCIENCES

Nanomedicinal strategies to treat multidrug-resistant tumors: current progress

(2010) Xiaowei Dong et al.   Nanomedicine

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

(2010) R Piñeiro et al.   ONCOGENE

Inhibition of ABCB1 (MDR1) Expression by an siRNA Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma

(2010) Michiro Susa et al.   PLoS One

Overcoming Multidrug Resistance in Human Cancer Cells by Natural Compounds

(2010) Tomohiro Nabekura   Toxins

A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen

(2009) Paul Ruff et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells

(2009) D. Turk et al.   CANCER RESEARCH

Small-Molecule Multidrug Resistance-Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

(2009) C. A. Burkhart et al.   CANCER RESEARCH

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

(2009) Paul D. W. Eckford et al.   CHEMICAL REVIEWS

A Phase I Study of the P-Glycoprotein Antagonist Tariquidar in Combination with Vinorelbine

(2009) J. Abraham et al.   CLINICAL CANCER RESEARCH

Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas

(2009) Hua-Yun Chen et al.   INTERNATIONAL JOURNAL OF CANCER

NSC23925, Identified in a High-Throughput Cell-Based Screen, Reverses Multidrug Resistance

(2009) Zhenfeng Duan et al.   PLoS One

Is resistance useless? Multidrug resistance and collateral sensitivity

(2009) Matthew D. Hall et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of Prostaglandin Transporters in Colorectal Neoplasia

(2008) V. R. Holla et al.   Cancer Prevention Research

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

(2008) C.-l. Dai et al.   CANCER RESEARCH

Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration

(2008) B Chapuy et al.   LEUKEMIA

A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia

(2008) Jeffrey E. Lancet et al.   LEUKEMIA RESEARCH

Constitutive Expression of the ATP-Binding Cassette Transporter ABCG2 Enhances the Growth Potential of Early Human Hematopoietic Progenitors

(2007) Farid Ahmed et al.   STEM CELLS