Screening dietary flavonoids for the reversal of P-glycoprotein-mediated multidrug resistance in cancer

Emerging Significance of Flavonoids as P-Glycoprotein Inhibitors in Cancer Chemotherapy

(2016) Tripta Bansal et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Prediction of drug–ABC-transporter interaction — Recent advances and future challenges

(2015) Floriane Montanari et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of Fourth Generation ABC Inhibitors from Natural Products: A Novel Approach to Overcome Cancer Multidrug Resistance

(2015) Subburayan Karthikeyan et al.   Anti-Cancer Agents in Medicinal Chemistry

Mutational studies to understand the structure–function relationship in multidrug efflux transporters: Applications for distinguishing mutants with high specificity

(2015) M. Michael Gromiha et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

(2015) Hossam M. Abdallah et al.   Journal of Advanced Research

Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)-Valine-Derived Thiazole Amino Acid

(2014) Satyakam Singh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

(2014) Ana Ferreira et al.   PHYTOCHEMISTRY REVIEWS

Molecular docking and P-glycoprotein inhibitory activity of Flavonoids

(2014) Jayasimha Rayalu Daddam et al.   Interdisciplinary Sciences-Computational Life Sciences

Design, Synthesis, and Biological Evaluation of (S)-Valine Thiazole-Derived Cyclic and Noncyclic Peptidomimetic Oligomers as Modulators of Human P-Glycoprotein (ABCB1)

(2013) Satyakam Singh et al.   CHEMBIOCHEM

Combined QSAR and molecule docking studies on predicting P-glycoprotein inhibitors

(2013) Wen Tan et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: Possible role of cytochrome p450 3A4 and P-glycoprotein inhibition by baicalein

(2011) Cheng Li et al.   ARCHIVES OF PHARMACAL RESEARCH

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

(2011) Z. Shi et al.   CANCER RESEARCH

Improving Cancer Chemotherapy with Modulators of ABC Drug Transporters

(2011) S. Shukla et al.   CURRENT DRUG TARGETS

Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy

(2011) Chung-Pu Wu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain

(2011) Gugan Kothandan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Predicting P-Glycoprotein-Mediated Drug Transport Based On Support Vector Machine and Three-Dimensional Crystal Structure of P-glycoprotein

(2011) Zsolt Bikadi et al.   PLoS One

Exhaustive Sampling of Docking Poses Reveals Binding Hypotheses for Propafenone Type Inhibitors of P-Glycoprotein

(2011) Freya Klepsch et al.   PLoS Computational Biology

A Quantitative Structure–Activity Relationship for the Modulation Effects of Flavonoids on P-Glycoprotein-Mediated Transport

(2010) Ming-Thau Sheu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers

(2009) Kyoung-Ah Kim et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps - first come, first served?

(2009) Robert Ernst et al.   FEBS Journal

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Molecular models of human P-glycoprotein in two different catalytic states

(2009) Jean-Paul Becker et al.   BMC STRUCTURAL BIOLOGY

A 3D linear solvation energy model to quantify the affinity of flavonoid derivatives toward P-glycoprotein

(2008) Julien Boccard et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Role of the Active-Site Solvent in the Thermodynamics of Factor Xa Ligand Binding

(2008) Robert Abel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY