Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump

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Solid-State Fermentation as a Strategy to Improve the Bioactive Compounds Recovery from Larrea tridentata Leaves

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Traditional Chinese Medicine Remedy to Jury: The Pharmacological Basis for the Use of Shikonin as an Anticancer Therapy

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RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms

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Inhibition of multidrug efflux as a strategy to prevent biofilm formation

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(2013) Ryosuke Nakashima et al.   NATURE

Mutations in MexB that affect the efflux of antibiotics with cytoplasmic targets

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Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

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Computational discovery of putative quorum sensing inhibitors against LasR and RhlR receptor proteins of Pseudomonas aeruginosa

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Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

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The urgent need for new antibacterial agents

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Detailed Investigations on the Solid Cell Culture and Antimicrobial Activities of the IranianArnebia euchroma

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(2011) Laura JV Piddock   LANCET INFECTIOUS DISEASES

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

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Toward prediction of functional protein pockets using blind docking and pocket search algorithms

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Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments

(2011) Q. Zhang et al.   SCIENCE

Optimized Nile Red Efflux Assay of AcrAB-TolC Multidrug Efflux System Shows Competition between Substrates

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In-vitro Antiproliferative Activity of Benzopyranone Derivatives in Comparison with Standard Chemotherapeutic Drugs

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Promiscuous partnering and independent activity of MexB, the multidrug transporter protein fromPseudomonas aeruginosa

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Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype

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Genetic Exchange of Multidrug Efflux Pumps among Two Enterobacterial Species with Distinctive Ecological Niches

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

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