Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies

(2017) Ranjeet Prasad Dash et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance

(2017) Qianqian Qiu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses

(2016) Onat Kadioglu et al.   BIOCHEMICAL PHARMACOLOGY

Molecular mechanisms for tumour resistance to chemotherapy

(2016) Shu-Ting Pan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

neo -Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells

(2016) Gui-Min Xue et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quantum Chemical and Docking Insights into Bioavailability Enhancement of Curcumin by Piperine in Pepper

(2016) Vaishali M. Patil et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity

(2016) Sahar A. Khaleel et al.   Scientific Reports

Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats

(2016) Yan Gao et al.   Scientific Reports

Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay

(2016) Elodie Jouan et al.   Pharmaceutics

Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy

(2016) Chun-ge Zhang et al.   Scientific Reports

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents

(2015) Maria Laura Pati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Stereoselective Regulation of P-gp Activity by Clausenamide Enantiomers in Caco-2, KB/KBv and Brain Microvessel Endothelial Cells

(2015) Chuan-jiang Zhu et al.   PLoS One

Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells

(2015) Wenzhe Ma et al.   Scientific Reports

P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

(2015) Hossam M. Abdallah et al.   Journal of Advanced Research

Milestones in Breast Cancer Treatment

(2014) Stefano Zurrida et al.   Breast Journal

In silico Study on the Interaction between P-glycoprotein and Its Inhibitors at the Drug Binding Pocket

(2014) Namseok Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

(2014) Rachael A McCloy et al.   CELL CYCLE

Compounds from Chinese herbal medicines as reversal agents for P-glycoprotein-mediated multidrug resistance in tumours

(2014) C. Li et al.   Clinical & Translational Oncology

ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development

(2014) Young Choi et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Trimethoxybenzanilide-Based P-Glycoprotein Modulators: An Interesting Case of Lipophilicity Tuning by Intramolecular Hydrogen Bonding

(2014) Piero Tardia et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Drug Rescue Distinguishes between Different Structural Models of Human P-Glycoprotein

(2013) Tip W. Loo et al.   BIOCHEMISTRY

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

In silico model for P-glycoprotein substrate prediction: insights from molecular dynamics and in vitro studies

(2013) Rameshwar Prajapati et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The influence of lipophilicity in drug discovery and design

(2012) John A Arnott et al.   Expert Opinion on Drug Discovery

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors

(2012) Durg Vijay Singh et al.   JOURNAL OF MOLECULAR MODELING

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Improving Cancer Chemotherapy with Modulators of ABC Drug Transporters

(2011) S. Shukla et al.   CURRENT DRUG TARGETS

Potent Galloyl-Based Selective Modulators Targeting Multidrug Resistance Associated Protein 1 and P-glycoprotein

(2011) Raffaella Zoe Pellicani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro

(2011) Undurti N Das et al.   Lipids in Health and Disease

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

(2010) R. J. Kelly et al.   CLINICAL CANCER RESEARCH

Molecular dynamics simulation with weak coupling to heat and material baths

(2010) Hossein Eslami et al.   JOURNAL OF CHEMICAL PHYSICS

Multiple Drug Resistance Mechanisms in Cancer

(2010) Bruce C. Baguley   MOLECULAR BIOTECHNOLOGY

PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line

(2009) Stefan Harmsen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

(2007) Nicola Antonio Colabufo et al.   BIOORGANIC & MEDICINAL CHEMISTRY