The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation

A New Sandwich Immunoassay for Detection of the α-Secretase Cleaved, Soluble Amyloid-β Protein Precursor in Cerebrospinal Fluid and Serum

(2018) Mara Taverna et al.   JOURNAL OF ALZHEIMERS DISEASE

ADAM Proteases and Gastrointestinal Function

(2016) Jennifer C. Jones et al.   Annual Review of Physiology

ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular BedsNovelty and Significance

(2016) Rolake O. Alabi et al.   CIRCULATION RESEARCH

Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models

(2016) Caterina Camodeca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells

(2016) Elodie J. Siney et al.   MOLECULAR NEUROBIOLOGY

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

(2016) Alexandra L. Matthews et al.   PLATELETS

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

(2016) Peer-Hendrik Kuhn et al.   eLife

WGE: a CRISPR database for genome engineering: Fig. 1.

(2015) Alex Hodgkins et al.   BIOINFORMATICS

TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

(2015) Stéphanie Jouannet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions

(2015) Peter J. Noy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

(2015) Allen C. Chen et al.   JOURNAL OF CELL BIOLOGY

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

(2015) Emanuela Pasciuto et al.   NEURON

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling

(2015) Neha Woods et al.   Oncotarget

The sheddase ADAM10 is a potent modulator of prion disease

(2015) Hermann C Altmeppen et al.   eLife

ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing

(2015) Maria Raffaella Zocchi et al.   OncoImmunology

The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity

(2014) Franziska S. Hoffmann et al.   JOURNAL OF IMMUNOLOGY

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

(2014) A. J. Groot et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

ADAM10 Negatively Regulates Neuronal Differentiation during Spinal Cord Development

(2014) Xin Yan et al.   PLoS One

SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation

(2014) C Saraceno et al.   Cell Death & Disease

ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A

(2014) Erez Romi et al.   Nature Communications

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

ADAM10 in Synaptic Physiology and Pathology

(2013) Stefano Musardo et al.   Neurodegenerative Diseases

Three Mechanisms Assemble Central Nervous System Nodes of Ranvier

(2013) Keiichiro Susuki et al.   NEURON

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

(2012) Elizabeth J. Haining et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

(2012) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by γ-secretase complex

(2011) Yusuke Nagara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures

(2011) K. Glomski et al.   BLOOD

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer’s disease

(2010) Roberta Epis et al.   BRAIN

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

An Arginine Stretch Limits ADAM10 Exit from the Endoplasmic Reticulum

(2010) Elena Marcello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM-10-Mediated N-Cadherin Cleavage Is Protein Kinase C-  Dependent and Promotes Glioblastoma Cell Migration

(2009) Z. A. Kohutek et al.   JOURNAL OF NEUROSCIENCE

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY