Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization

(2017) Hidekazu Higashide et al.   JOURNAL OF NEUROCHEMISTRY

Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors

(2016) Kaleeckal G. Harikumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein

(2016) Laura Dominguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio

(2016) Ting-Hai Xu et al.   Cell Discovery

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase

(2015) Edith Winkler et al.   BIOCHEMISTRY

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

(2015) Marie Decock et al.   FEBS Open Bio

Structural Heterogeneity in Transmembrane Amyloid Precursor Protein Homodimer Is a Consequence of Environmental Selection

(2014) Laura Dominguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational Changes Induced by the A21G Flemish Mutation in the Amyloid Precursor Protein Lead to Increased Aβ Production

(2014) Tzu-Chun Tang et al.   STRUCTURE

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Competition Between Homodimerization and Cholesterol Binding to the C99 Domain of the Amyloid Precursor Protein

(2013) Yuanli Song et al.   BIOCHEMISTRY

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

(2013) Mitko Dimitrov et al.   Nature Communications

Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment

(2012) Kirill D. Nadezhdin et al.   FEBS LETTERS

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Structural features of the KPI domain control APP dimerization, trafficking, and processing

(2011) Naouel Ben Khalifa et al.   FASEB JOURNAL

Molecular Determinants and Thermodynamics of the Amyloid Precursor Protein Transmembrane Domain Implicated in Alzheimer's Disease

(2011) Hao Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Notch dimerization is required for leukemogenesis and T-cell development

(2010) H. Liu et al.   GENES & DEVELOPMENT

Molecular Structure and Dimeric Organization of the Notch Extracellular Domain as Revealed by Electron Microscopy

(2010) Deborah F. Kelly et al.   PLoS One

Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production

(2009) Simone Eggert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane Structures of Amyloid Precursor Protein Dimer Predicted by Replica-Exchange Molecular Dynamics Simulations

(2009) Naoyuki Miyashita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Studies in Alzheimer Disease

(2008) Stephen C. Waring et al.   ARCHIVES OF NEUROLOGY

Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?†‡

(2008) Andrew J. Beel et al.   BIOCHEMISTRY

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

(2008) Paul M Gorman et al.   BMC NEUROSCIENCE

Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

(2008) Pascal Kienlen-Campard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY