Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

(2019) Jason Yi et al.   Nature Communications

Do tumor cells escape from natural killer cell cytotoxicity by mimicking dendritic cells?

(2019) Hannah Wurzer et al.   Oncotarget

Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells

(2018) Alexandre F. Carisey et al.   CURRENT BIOLOGY

The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse

(2018) Raïssa Houmadi et al.   Cell Reports

Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity

(2018) Antoun Al Absi et al.   CANCER RESEARCH

Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive

(2018) Marton Keszei et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells

(2018) Hye-Ran Kim et al.   Nature Communications

Natural Killer Cells: Development, Maturation, and Clinical Utilization

(2018) Alex M. Abel et al.   Frontiers in Immunology

Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse

(2018) John A. Hammer et al.   Annual Review of Immunology

Tricking the balance: NK cells in anti-cancer immunity

(2017) Jens Pahl et al.   IMMUNOBIOLOGY

New insights into the role of EMT in tumor immune escape

(2017) Stéphane Terry et al.   Molecular Oncology

Actin cortex architecture regulates cell surface tension

(2017) Priyamvada Chugh et al.   NATURE CELL BIOLOGY

Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes

(2017) Alex T. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Communication at the Immunological Synapse

(2017) Roshni Basu et al.   TRENDS IN CELL BIOLOGY

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

(2017) Stéphane Terry et al.   OncoImmunology

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung

(2016) Sehui Kim et al.   HUMAN PATHOLOGY

Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling

(2016) Pieta K. Mattila et al.   JOURNAL OF CELL BIOLOGY

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse

(2016) Sricharan Murugesan et al.   JOURNAL OF CELL BIOLOGY

The FAK–Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin

(2016) Vinay Swaminathan et al.   MOLECULAR BIOLOGY OF THE CELL

Varying label density allows artifact-free analysis of membrane-protein nanoclusters

(2016) Florian Baumgart et al.   NATURE METHODS

Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies

(2016) Yunmin Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin and Actin-Binding Proteins

(2016) Thomas D. Pollard   Cold Spring Harbor Perspectives in Biology

Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

(2016) Marisa A. P. Baptista et al.   Nature Communications

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

(2016) Peter J. Wen et al.   Nature Communications

Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse

(2016) Claire Hivroz et al.   Frontiers in Immunology

Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse

(2016) William A. Comrie et al.   Frontiers in Immunology

Human Primary Immune Cells Exhibit Distinct Mechanical Properties that Are Modified by Inflammation

(2015) Nathalie Bufi et al.   BIOPHYSICAL JOURNAL

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

(2015) Erdem Tabdanov et al.   Integrative Biology

Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies

(2015) Carin I.M. Dahlberg et al.   JOURNAL OF AUTOIMMUNITY

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration

(2015) A. Schaefer et al.   JOURNAL OF CELL SCIENCE

UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion

(2015) Yoshie Iizuka et al.   JOURNAL OF IMMUNOLOGY

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts

(2015) Dessislava Malinova et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

HCMV pUL135 Remodels the Actin Cytoskeleton to Impair Immune Recognition of Infected Cells

(2014) Richard J. Stanton et al.   Cell Host & Microbe

Connecting the Cytoskeleton to the Endoplasmic Reticulum and Golgi

(2014) Pinar S. Gurel et al.   CURRENT BIOLOGY

Actin cytoskeletal defects in immunodeficiency

(2014) Dale A. Moulding et al.   IMMUNOLOGICAL REVIEWS

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

T Cell-Dendritic Cell Immunological Synapses Contain TCR-dependent CD28-CD80 Clusters That Recruit Protein Kinase C 

(2014) S.-Y. Tseng et al.   JOURNAL OF IMMUNOLOGY

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A

(2014) E. M. Mace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

T cell antigen receptor activation and actin cytoskeleton remodeling

(2013) Sudha Kumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

(2013) N. Fiegler et al.   BLOOD

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

(2013) J. A. Lopez et al.   BLOOD

Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

(2013) A. G. Ramsay et al.   BLOOD

Controversy and consensus regarding myosin II function at the immunological synapse

(2013) John A Hammer et al.   CURRENT OPINION IN IMMUNOLOGY

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

The expanding superfamily of gelsolin homology domain proteins

(2013) Umesh Ghoshdastider et al.   Cytoskeleton

Centrosome Polarization in T Cells: A Task for Formins

(2013) Laura Andrés-Delgado et al.   Frontiers in Immunology

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity

(2013) Joanna Baginska et al.   Frontiers in Immunology

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

(2012) A. G. Ramsay et al.   BLOOD

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Bundling actin filaments from membranes: some novel players

(2012) Clément Thomas   Frontiers in Plant Science

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse

(2012) Sudha Kumari et al.   Frontiers in Immunology

Human NK cell lytic granules and regulation of their exocytosis

(2012) Konrad Krzewski et al.   Frontiers in Immunology

Actin Engine in Immunological Synapse

(2012) Indre Piragyte et al.   Immune Network

Multiple distinct NK-cell synapses

(2011) E. M. Mace et al.   BLOOD

Cytoskeletal stabilization of inhibitory interactions in immunologic synapses of mature human dendritic cells with natural killer cells

(2011) R. Barreira da Silva et al.   BLOOD

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

(2011) G. Bouma et al.   BLOOD

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

(2011) Jane C Stinchcombe et al.   BMC BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling

(2011) R. Calvez et al.   HAEMATOLOGICA

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

(2011) Nuria Martínez-Martín et al.   IMMUNITY

Mechanical Interactions between Dendritic Cells and T Cells Correlate with T Cell Responsiveness

(2011) T. S. Lim et al.   JOURNAL OF IMMUNOLOGY

Molecular Mechanisms of Natural Killer Cell Activation

(2011) Yenan T. Bryceson et al.   Journal of Innate Immunity

Dynamic actin remodeling during epithelial–mesenchymal transition depends on increased moesin expression

(2011) Jennifer Haynes et al.   MOLECULAR BIOLOGY OF THE CELL

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

(2011) Gregory D. Rak et al.   PLOS BIOLOGY

Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy

(2011) Alice C. N. Brown et al.   PLOS BIOLOGY

Actin cytoskeleton dynamics and the cell division cycle

(2010) Yi-Wen Heng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

(2010) Lisa S. Westerberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Occupancy of Lymphocyte LFA-1 by Surface-Immobilized ICAM-1 Is Critical for TCR- but Not for Chemokine-Triggered LFA-1 Conversion to an Open Headpiece High-Affinity State

(2010) S. W. Feigelson et al.   JOURNAL OF IMMUNOLOGY

Tethering of Intercellular Adhesion Molecule on Target Cells Is Required for LFA-1-Dependent NK Cell Adhesion and Granule Polarization

(2010) C. C. Gross et al.   JOURNAL OF IMMUNOLOGY

Regulation of actin cytoskeleton dynamics in cells

(2010) Sung Haeng Lee et al.   MOLECULES AND CELLS

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Regulation of human NK-cell cytokine and chemokine production by target cell recognition

(2009) C. Fauriat et al.   BLOOD

Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin

(2009) Meixiang Yang et al.   IMMUNOLOGY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Myosin IIA Associates with NK Cell Lytic Granules to Enable Their Interaction with F-Actin and Function at the Immunological Synapse

(2009) K. B. Sanborn et al.   JOURNAL OF IMMUNOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

T cell antigen receptor signaling and immunological synapse stability require myosin IIA

(2009) Tal Ilani et al.   NATURE IMMUNOLOGY

Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy

(2009) B. H. Hosseini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Actin bundling in plants

(2009) Clément Thomas et al.   CELL MOTILITY AND THE CYTOSKELETON

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

The Actin Cytoskeleton in T Cell Activation

(2008) Janis K. Burkhardt et al.   Annual Review of Immunology

T Cell Receptor Microcluster Transport through Molecular Mazes Reveals Mechanism of Translocation

(2008) Andrew L. DeMond et al.   BIOPHYSICAL JOURNAL

Hypoxia Increases Tumor Cell Shedding of MHC Class I Chain-Related Molecule: Role of Nitric Oxide

(2008) D. R. Siemens et al.   CANCER RESEARCH

Resistance of Tumor Cells to Cytolytic T Lymphocytes Involves Rho-GTPases and Focal Adhesion Kinase Activation

(2008) Soraya Abouzahr-Rifai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1

(2008) Jeffrey C. Nolz et al.   JOURNAL OF CELL BIOLOGY

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

(2008) Alan G. Ramsay et al.   JOURNAL OF CLINICAL INVESTIGATION

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES