Actin cytoskeletal defects in immunodeficiency

Expression of Wiskott-Aldrich Syndrome Protein in Dendritic Cells Regulates Synapse Formation and Activation of Naive CD8+ T Cells

(2014) J. Pulecio et al.   JOURNAL OF IMMUNOLOGY

Wiskott-Aldrich syndrome: a comprehensive review

(2013) Michel J. Massaad et al.   Annals of the New York Academy of Sciences

Regulatory B cells in autoimmune diseases

(2013) Min Yang et al.   Cellular & Molecular Immunology

The Wiskott-Aldrich Syndrome: The Actin Cytoskeleton and Immune Cell Function

(2013) Michael P. Blundell et al.   DISEASE MARKERS

Genetic, Clinical, and Laboratory Markers for DOCK8 Immunodeficiency Syndrome

(2013) Jeremiah C. Davis et al.   DISEASE MARKERS

T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation

(2013) Yuko Watanabe et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency

(2013) Melissa C. Mizesko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation

(2013) Despina Moshous et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cytoplasm of living cells behaves as a poroelastic material

(2013) Emad Moeendarbary et al.   NATURE MATERIALS

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9

(2013) J. L. Gallop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DOCK8 deficiency

(2012) Helen C. Su et al.   Annals of the New York Academy of Sciences

Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration

(2012) A. J. J. Worth et al.   BLOOD

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function

(2012) L. S. Westerberg et al.   BLOOD

Characteristics and outcome of early-onset, severe forms of Wiskott-Aldrich syndrome

(2012) N. Mahlaoui et al.   BLOOD

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules

(2012) S. Kumar et al.   BLOOD

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

(2012) E. C. Smith et al.   BLOOD

Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

(2012) D. A. Moulding et al.   BLOOD

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice

(2012) M. Recher et al.   BLOOD

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

(2012) Y. Harada et al.   BLOOD

Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait

(2012) Waleed Al-Herz et al.   CLINICAL IMMUNOLOGY

Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp

(2012) Rikiya Sato et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

(2012) Philipp A. Lang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Additional Diverse Findings Expand the Clinical Presentation of DOCK8 Deficiency

(2012) Ozden Sanal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Clinical, Immunological and Molecular Characterization of DOCK8 and DOCK8-like Deficient Patients: Single Center Experience of Twenty Five Patients

(2012) Zobaida Alsum et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections

(2012) Amandine Crequer et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

(2012) Gaetana Lanzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitylation-Dependent Negative Regulation of WASp Is Essential for Actin Cytoskeleton Dynamics

(2012) B. Reicher et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

(2012) Haifa H Jabara et al.   NATURE IMMUNOLOGY

Platelets from WAS patients show an increased susceptibility toex vivophagocytosis

(2012) Amanda Prislovsky et al.   PLATELETS

The Chemotactic Defect in Wiskott-Aldrich Syndrome Macrophages Is Due to the Reduced Persistence of Directional Protrusions

(2012) Dan Ishihara et al.   PLoS One

Actin cortex mechanics and cellular morphogenesis

(2012) Guillaume Salbreux et al.   TRENDS IN CELL BIOLOGY

Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis

(2012) M. Kan-O et al.   Biology Open

Autoimmunity in Wiskott–Aldrich Syndrome: An Unsolved Enigma

(2012) Marco Catucci et al.   Frontiers in Immunology

Cutaneous Manifestations of DOCK8 Deficiency Syndrome

(2011) Emily Y. Chu   ARCHIVES OF DERMATOLOGY

Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells

(2011) M. Adriani et al.   BLOOD

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

(2011) G. Bouma et al.   BLOOD

Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study

(2011) D. Moratto et al.   BLOOD

Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: Implications for pathogenesis and potential detection by newborn screening

(2011) Majed Dasouki et al.   CLINICAL IMMUNOLOGY

Spire-Type Actin Nucleators Cooperate with Formin-2 to Drive Asymmetric Oocyte Division

(2011) Sybille Pfender et al.   CURRENT BIOLOGY

DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory

(2011) Teresa Lambe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tyrosine phosphorylation of WASP promotes calpain-mediated podosome disassembly

(2011) L. Macpherson et al.   HAEMATOLOGICA

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

(2011) Nuria Martínez-Martín et al.   IMMUNITY

RhoG is required for both FcγR- and CR3-mediated phagocytosis

(2011) George Tzircotis et al.   JOURNAL OF CELL SCIENCE

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function

(2011) Jordan S. Orange et al.   JOURNAL OF CLINICAL INVESTIGATION

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

(2011) Shirly Becker-Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

(2011) Katrina L. Randall et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Phospholipase D2-Grb2-WASp Heterotrimer Regulates Leukocyte Phagocytosis in a Two-Step Mechanism

(2011) S. Kantonen et al.   MOLECULAR AND CELLULAR BIOLOGY

Unraveling the enigma: progress towards understanding the coronin family of actin regulators

(2011) Keefe T. Chan et al.   TRENDS IN CELL BIOLOGY

Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein

(2010) N. P. Nikolov et al.   BLOOD

A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes

(2010) S. O. Burns et al.   BLOOD

Curative treatment of autosomal-recessive hyper-IgE syndrome by hematopoietic cell transplantation

(2010) S A Gatz et al.   BONE MARROW TRANSPLANTATION

Determinants of Myosin II Cortical Localization during Cytokinesis

(2010) Ryota Uehara et al.   CURRENT BIOLOGY

Clinical spectrum, pathophysiology and treatment of the Wiskott–Aldrich syndrome

(2010) Michael H Albert et al.   CURRENT OPINION IN HEMATOLOGY

Mechanism of regulation of autoimmunity by iNKT cells

(2010) Jan Novak et al.   CYTOKINE

Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection

(2010) Stefan Porubsky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: Analysis of function and distribution in lymphoid organs

(2010) Sara Trifari et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia

(2010) Deborah Accetta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

(2010) Lisa S. Westerberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Wiskott-Aldrich syndrome protein regulates CTL cytotoxicity and is required for efficient killing of B cell lymphoma targets

(2010) Julie De Meester et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Successful Long-Term Correction of Autosomal Recessive Hyper-IgE Syndrome due to DOCK8 Deficiency by Hematopoietic Stem Cell Transplantation

(2010) T. C. Bittner et al.   KLINISCHE PADIATRIE

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

(2010) C Ragu et al.   LEUKEMIA

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Role of WASp in the Pathogenesis of Dysregulated TH1 Immunity in Human Wiskott-Aldrich Syndrome

(2010) M. D. Taylor et al.   Science Translational Medicine

Platelet Formation

(2010) Jonathan N. Thon et al.   SEMINARS IN HEMATOLOGY

Th17 cells, Jobʼs syndrome and HIV: opportunities for bacterial and fungal infections

(2010) Joshua D Milner et al.   Current Opinion in HIV and AIDS

Role for MKL1 in megakaryocytic maturation

(2009) E.-c. Cheng et al.   BLOOD

Rho GTPases in hematopoiesis and hemopathies

(2009) J. C. Mulloy et al.   BLOOD

Cellular signaling of Dock family proteins in neural function

(2009) Yuki Miyamoto et al.   CELLULAR SIGNALLING

Late-onset adenosine deaminase deficiency presenting with Heck’s disease

(2009) Hasibe Artac et al.   EUROPEAN JOURNAL OF PEDIATRICS

Antiplatelet antibodies in WASP(−) mice correlate with evidence of increased in vivo platelet consumption

(2009) Bindumadhav M. Marathe et al.   EXPERIMENTAL HEMATOLOGY

G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia

(2009) K. Beel et al.   HAEMATOLOGICA

The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8+ Dendritic Cells

(2009) Ariel Savina et al.   IMMUNITY

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation

(2009) Gerben Bouma et al.   IMMUNOBIOLOGY

Defects along the TH17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome

(2009) Shadi Al Khatib et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function

(2009) Michela Locci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coronin 1 Is Essential for IgM-Mediated Ca2+ Mobilization in B Cells but Dispensable for the Generation of Immune Responses In Vivo

(2009) B. Combaluzier et al.   JOURNAL OF IMMUNOLOGY

Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT Cells

(2009) A. Astrakhan et al.   JOURNAL OF IMMUNOLOGY

p53-cofactor JMY is a multifunctional actin nucleation factor

(2009) J. Bradley Zuchero et al.   NATURE CELL BIOLOGY

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

(2009) Katrina L Randall et al.   NATURE IMMUNOLOGY

Combined Immunodeficiency Associated withDOCK8Mutations

(2009) Qian Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphorylation of WASp is a key regulator of activity and stability in vivo

(2009) M. P. Blundell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells

(2008) Asuka Kato et al.   BIOCHEMICAL JOURNAL

WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function

(2008) L. S. Westerberg et al.   BLOOD

Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis

(2008) A. Meyer-Bahlburg et al.   BLOOD

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene

(2008) Karolien Beel et al.   BRITISH JOURNAL OF HAEMATOLOGY

WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport

(2008) Kenneth G. Campellone et al.   CELL

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a coronin-1A mutation and a chromosome 16p11.2 deletion

(2008) Lawrence R. Shiow et al.   CLINICAL IMMUNOLOGY

Interactions between Myosin and Actin Crosslinkers Control Cytokinesis Contractility Dynamics and Mechanics

(2008) Elizabeth M. Reichl et al.   CURRENT BIOLOGY

Rapid platelet turnover in WASP(−) mice correlates with increased ex vivo phagocytosis of opsonized WASP(−) platelets

(2008) Amanda Prislovsky et al.   EXPERIMENTAL HEMATOLOGY

Activation of the Small GTPase Rac2 via the B Cell Receptor Regulates B Cell Adhesion and Immunological-Synapse Formation

(2008) Eloisa Arana et al.   IMMUNITY

The Lupus-Related Lmb3 Locus Contains a Disease-Suppressing Coronin-1A Gene Mutation

(2008) M. Katarina Haraldsson et al.   IMMUNITY

Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

(2008) Hao Yuan Kueh et al.   JOURNAL OF CELL BIOLOGY

Analysis of WASp function during the wound inflammatory response - live-imaging studies in zebrafish larvae

(2008) A. Cvejic et al.   JOURNAL OF CELL SCIENCE

Hierarchical Regulation of WASP/WAVE Proteins

(2008) Shae B. Padrick et al.   MOLECULAR CELL

Regulation of T cell survival through coronin-1–mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering

(2008) Philipp Mueller et al.   NATURE IMMUNOLOGY

The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency

(2008) Lawrence R Shiow et al.   NATURE IMMUNOLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY