Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

(2012) A. G. Ramsay et al.   BLOOD

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

(2012) A Lopez-Girona et al.   LEUKEMIA

The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes

(2011) R. Evans et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of integrin affinity on cell surfaces

(2011) Thomas Schürpf et al.   EMBO JOURNAL

Rho GTPases: Masters of T lymphocyte migration and activation

(2011) Pablo Rougerie et al.   IMMUNOLOGY LETTERS

Lenalidomide can be safely combined with R-CHOP (R2CHOP) in the initial chemotherapy for aggressive B-cell lymphomas: phase I study

(2011) G S Nowakowski et al.   LEUKEMIA

Final results of a multicenter phase 1 study of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia

(2011) Clemens-Martin Wendtner et al.   LEUKEMIA & LYMPHOMA

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

CXCL12-induced chemotaxis is impaired in T cells from patients with ZAP-70-negative chronic lymphocytic leukemia

(2010) M. Borge et al.   HAEMATOLOGICA

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration

(2010) Sarah J. Heasman et al.   JOURNAL OF CELL BIOLOGY

Single-Agent Lenalidomide in the Treatment of Previously Untreated Chronic Lymphocytic Leukemia

(2010) Christine I. Chen et al.   JOURNAL OF CLINICAL ONCOLOGY

Rac Activation by the T-Cell Receptor Inhibits T Cell Migration

(2010) Eva Cernuda-Morollón et al.   PLoS One

Immune dysfunction in chronic lymphocytic leukemia T cells and lenalidomide as an immunomodulatory drug

(2009) A. G. Ramsay et al.   HAEMATOLOGICA

Integrins in immunity

(2009) R. Evans et al.   JOURNAL OF CELL SCIENCE

Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module

(2009) Matteo Bolomini-Vittori et al.   NATURE IMMUNOLOGY

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

E -TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction

(2009) G. Gorgun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration

(2008) Nicole A. Morin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL