The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System

Antibody-Drug Conjugates (ADC) Against Cancer Stem-Like Cells (CSC)—Is There Still Room for Optimism?

(2019) Fabrizio Marcucci et al.   Frontiers in Oncology

NK-cell Editing Mediates Epithelial-to-Mesenchymal Transition via Phenotypic and Proteomic Changes in Melanoma Cell Lines

(2018) Leticía Huergo-Zapico et al.   CANCER RESEARCH

Epithelial-mesenchymal transition leads to NK cell–mediated metastasis-specific immunosurveillance in lung cancer

(2018) Peter J. Chockley et al.   JOURNAL OF CLINICAL INVESTIGATION

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

(2018) Mana Taki et al.   Nature Communications

Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC)

(2018) Young Kwang Chae et al.   Scientific Reports

CSF-1/CSF-1R axis is associated with epithelial/mesenchymal hybrid phenotype in epithelial-like inflammatory breast cancer

(2018) Kazuharu Kai et al.   Scientific Reports

How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress—Therapeutic Implications

(2018) Fabrizio Marcucci et al.   Frontiers in Pharmacology

Extracellular vesicle-mediated EBAG9 transfer from cancer cells to tumor microenvironment promotes immune escape and tumor progression

(2018) Toshiaki Miyazaki et al.   Oncogenesis

Snail-overexpressing Cancer Cells Promote M2-Like Polarization of Tumor-Associated Macrophages by Delivering MiR-21-Abundant Exosomes

(2018) Chia-Hsin Hsieh et al.   NEOPLASIA

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

(2018) Muhammad Zaeem Noman et al.   OncoImmunology

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Neutralization of IL-18 by IL-18 binding protein ameliorates bleomycin-induced pulmonary fibrosis via inhibition of epithelial-mesenchymal transition

(2018) Li-Ming Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IFN-r-induced IFIT5 promotes epithelial-to-mesenchymal transition in prostate cancer via microRNA processing

(2018) U-Ging Lo et al.   CANCER RESEARCH

NK cell-derived IFN-γ promotes hepatocellular carcinoma through EpCAM-EMT axis in hepatitis B virus transgenic mice

(2018) Yongyan Chen et al.   HEPATOLOGY

aPKC-ι/P-Sp1/Snail signaling induces epithelial-mesenchymal transition and immunosuppression in cholangiocarcinoma

(2017) Yawei Qian et al.   HEPATOLOGY

Exosomes Derived from Irradiated Esophageal Carcinoma-Infiltrating T Cells Promote Metastasis by Inducing the Epithelial–Mesenchymal Transition in Esophageal Cancer Cells

(2017) Hua Min et al.   PATHOLOGY & ONCOLOGY RESEARCH

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

(2017) Julien Faget et al.   Cell Reports

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

(2017) Stéphane Terry et al.   OncoImmunology

Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer

(2017) Sushil Kumar et al.   OncoImmunology

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

(2017) Muhammad Zaeem Noman et al.   OncoImmunology

Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression

(2017) Xiu-Ming Li et al.   PLoS One

Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes

(2016) Ryusuke Murakami et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency

(2016) Jasmine M. De Cock et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung

(2016) Sehui Kim et al.   HUMAN PATHOLOGY

TNF-α augments CXCR2 and CXCR3 to promote progression of renal cell carcinoma

(2016) Kuang-Hui Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

(2016) Yong Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling

(2016) Yasushi Shintani et al.   Journal of Thoracic Oncology

Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung cancer by downregulation of EGFR pathway

(2016) Janani Ravi et al.   MOLECULAR CARCINOGENESIS

Epithelial–mesenchymal transition: a new target in anticancer drug discovery

(2016) Fabrizio Marcucci et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition

(2016) Q Zhang et al.   ONCOGENE

TIM-3 promotes the metastasis of esophageal squamous cell carcinoma by targeting epithelial-mesenchymal transition via the Akt/GSK-3β/Snail signaling pathway

(2016) Baoen Shan et al.   ONCOLOGY REPORTS

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

(2016) Satyendra C. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High tumor-associated macrophages infiltration is associated with poor prognosis and may contribute to the phenomenon of epithelial–mesenchymal transition in gastric cancer

(2016) Jian-sheng Wang et al.   OncoTargets and Therapy

Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies

(2016) Charli Dominguez et al.   Cell Death & Disease

Sorafenib inhibits macrophage-mediated epithelial-mesenchymal transition in hepatocellular carcinoma

(2016) Yan-Ru Deng et al.   Oncotarget

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype

(2016) Fan Zhang et al.   Oncotarget

The co-stimulatory molecule B7-H3 promotes the epithelial-mesenchymal transition in colorectal cancer

(2016) Bo Jiang et al.   Oncotarget

Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity

(2016) Sabina Sangaletti et al.   Cell Reports

MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition

(2016) Justin M. David et al.   OncoImmunology

Anti-Cancer Stem-like Cell Compounds in Clinical Development – An Overview and Critical Appraisal

(2016) Fabrizio Marcucci et al.   Frontiers in Oncology

CCL21/CCR7 Axis Contributed to CD133+ Pancreatic Cancer Stem-Like Cell Metastasis via EMT and Erk/NF-κB Pathway

(2016) Lirong Zhang et al.   PLoS One

Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells

(2015) M Ricciardi et al.   BRITISH JOURNAL OF CANCER

High-mobility group Box 1: A novel inducer of the epithelial–mesenchymal transition in colorectal carcinoma

(2015) Lingyin Zhu et al.   CANCER LETTERS

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

(2015) M. P. Mak et al.   CLINICAL CANCER RESEARCH

IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)

(2015) XINXIN LONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8 + effector and memory T cell populations during infection

(2015) Kyla D. Omilusik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

(2015) Mary J. van Helden et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Soluble factors regulated by epithelial-mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment

(2015) Meggy Suarez-Carmona et al.   JOURNAL OF PATHOLOGY

PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma

(2015) Yiwei Wang et al.   MEDICAL ONCOLOGY

Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

(2015) Abdullah Alsuliman et al.   Molecular Cancer

TGF-β and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells

(2015) Xiao-Hui Chen et al.   MOLECULAR IMMUNOLOGY

CXCR7 mediates TGFβ1-promoted EMT and tumor-initiating features in lung cancer

(2015) Y-C Wu et al.   ONCOGENE

Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8–Akt–Slug pathway

(2015) C Visciano et al.   ONCOGENE

Intratumoral neutrophil granulocytes contribute to epithelial-mesenchymal transition in lung adenocarcinoma cells

(2015) Pingping Hu et al.   TUMOR BIOLOGY

Inflammatory mediators, tumor necrosis factor-α and interferon-γ, induce EMT in human PTC cell lines

(2015) NANNAN LV et al.   Oncology Letters

Protein kinase D2 contributes to TNF-α-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3β/β-catenin pathway in hepatocellular carcinoma

(2015) Yun Zhu et al.   Oncotarget

Recruited mast cells in the tumor microenvironment enhance bladder cancer metastasis via modulation of ERβ/CCL2/CCR2 EMT/MMP9 signals

(2015) Qun Rao et al.   Oncotarget

CD4+T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells–novel implications of CD4+T cells in pancreatic cancer development

(2015) Lisa Goebel et al.   OncoImmunology

TGF-β1-Induced Epithelial–Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells

(2015) Joel Johansson et al.   Frontiers in Oncology

Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells

(2015) Evan N. Cohen et al.   PLoS One

B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells

(2015) Yidan Zhi et al.   PLoS One

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine

(2015) Duane H. Hamilton et al.   Oncotarget

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer

(2014) Roheena Z. Panni et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial–mesenchymal transition

(2014) Xian-Shuo Cheng et al.   CANCER LETTERS

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

WEE1 Inhibition Alleviates Resistance to Immune Attack of Tumor Cells Undergoing Epithelial-Mesenchymal Transition

(2014) D. H. Hamilton et al.   CANCER RESEARCH

Interleukin-8 promotes human ovarian cancer cell migration by epithelial–mesenchymal transition induction in vitro

(2014) J. Yin et al.   Clinical & Translational Oncology

Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway

(2014) XIU-TAO FU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma

(2014) JIN-WEI MIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CCL18 promotes epithelial-mesenchymal transition, invasion and migration of pancreatic cancer cells in pancreatic ductal adenocarcinoma

(2014) FANBIN MENG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

(2014) Matjaz Rokavec et al.   JOURNAL OF CLINICAL INVESTIGATION

Snail Cooperates with Kras G12D In Vivo to Increase Stem Cell Factor and Enhance Mast Cell Infiltration

(2014) Lawrence M. Knab et al.   MOLECULAR CANCER RESEARCH

Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression

(2014) I Akalay et al.   ONCOGENE

Effect of IL-17A on the Migration and Invasion of NPC Cells and Related Mechanisms

(2014) Lixin Wang et al.   PLoS One

The CCL2/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling

(2014) Wei Chen et al.   TUMOR BIOLOGY

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

Molecular Bases for the Regulation of NKG2D Ligands in Cancer

(2014) Leticia Huergo-Zapico et al.   Frontiers in Immunology

Effects of Epithelial to Mesenchymal Transition on T Cell Targeting of Melanoma Cells

(2014) Katherine Woods et al.   Frontiers in Oncology

Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell-Mediated Lysis

(2013) I. Akalay et al.   CANCER RESEARCH

Bone Marrow-Derived CD11b+Jagged2+ Cells Promote Epithelial-to-Mesenchymal Transition and Metastasization in Colorectal Cancer

(2013) F. Caiado et al.   CANCER RESEARCH

Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2

(2013) Sabine Konradi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pushing tumor cells towards a malignant phenotype: Stimuli from the microenvironment, intercellular communications and alternative roads

(2013) Fabrizio Marcucci et al.   INTERNATIONAL JOURNAL OF CANCER

STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits

(2013) SEYUNG S. CHUNG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Epithelial-Mesenchymal Transition Induces an Antitumor Immune Response Mediated by NKG2D Receptor

(2013) A. Lopez-Soto et al.   JOURNAL OF IMMUNOLOGY

M2-polarized tumor-associated macrophages promoted epithelial–mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway

(2013) Chao-Ying Liu et al.   LABORATORY INVESTIGATION

CD14 regulates gastric cancer cell epithelial-mesenchymal transition and invasion in vitro

(2013) KANG LI et al.   ONCOLOGY REPORTS

Increased B Cell-Activating Factor Promotes Tumor Invasion and Metastasis in Human Pancreatic Cancer

(2013) Mitsuhito Koizumi et al.   PLoS One

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

(2012) Anne-Katrine Bonde et al.   BMC CANCER

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells

(2012) M. Z. Noman et al.   CANCER RESEARCH

CCL2 is critical for immunosuppression to promote cancer metastasis

(2012) Chie Kudo-Saito et al.   CLINICAL & EXPERIMENTAL METASTASIS

Improving drug penetration to curb tumor drug resistance

(2012) Fabrizio Marcucci et al.   DRUG DISCOVERY TODAY

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma

(2012) Naotake Funamizu et al.   INTERNATIONAL JOURNAL OF CANCER

Insights into cancer metastasis from a clinicopathologic perspective: Epithelial-Mesenchymal Transition is not a necessary step

(2012) Michael Herman Chui   INTERNATIONAL JOURNAL OF CANCER

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

(2012) Jennifer Landsberg et al.   NATURE

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

Anti-VEGF Treatment-Resistant Pancreatic Cancers Secrete Proinflammatory Factors That Contribute to Malignant Progression by Inducing an EMT Cell Phenotype

(2011) C. Carbone et al.   CLINICAL CANCER RESEARCH

TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells

(2011) Mikiko Kawata et al.   JOURNAL OF BIOCHEMISTRY

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

(2011) Benjamin Toh et al.   PLOS BIOLOGY

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL

Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells

(2009) M. Santisteban et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells

(2009) J. Wang et al.   INTERNATIONAL IMMUNOLOGY

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas

(2008) M Colomiere et al.   BRITISH JOURNAL OF CANCER

Snail Up-regulates Proinflammatory Mediators and Inhibits Differentiation in Oral Keratinocytes

(2008) J. G. Lyons et al.   CANCER RESEARCH

Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells

(2008) Mei-Jen Chuang et al.   CANCER SCIENCE

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

(2008) N. Dumont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA