Article
Immunology
Yuanyuan Li, Yan Yang, Aonan Zhao, Ningdi Luo, Mengyue Niu, Wenyan Kang, Anmu Xie, Hong Lu, Lei Chen, Jun Liu
Summary: This study identified a correlation between a profile of four peripheral immune biomarkers and the development and progression of Parkinson's disease. The findings provide a basis for identifying Parkinson's disease patients with abnormal inflammatory profiles and providing timely therapeutic interventions.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Oncology
Xin Wang, Weihao Lin, Tiejun Liu, Zhenyi Xu, Zhen Wang, Zheng Cao, Xiaoli Feng, Yibo Gao, Jie He
Summary: In this study, three distinct pyroptosis patterns were identified in LUAD patients based on the expression profiles of 48 PRGs, showing the crosstalk between pyroptosis and the tumor immune landscape. The Pyro score was established as an independent prognostic factor and immunotherapy predictor for LUAD, providing a new way towards personalized immunotherapeutic strategies.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Immunology
Giovanni Monteleone, Eleonora Franze, Edoardo Troncone, Claudia Maresca, Irene Marafini
Summary: Interleukin-34 (IL-34) plays a crucial role in chronic inflammatory bowel diseases (IBD) by promoting interactions between immune cells and stromal cells, leading to increased mucosal inflammation and production of fibrogenic molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rabab N. Hamzah, Karrer M. Alghazali, Alexandru S. Biris, Robert J. Griffin
Summary: Exosomes are small vesicles produced by various cell types that can transfer cellular components to target cells and affect cell signaling. Recent research suggests that the outcomes of exosome communication depend on the cell type and host cell environment. Key questions remain in cancer research regarding the selectivity of exosome uptake, methods for tracing uptake selectivity, and the impact of donor cell growth environment on cell interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Feride Eren, Lilly Schwieler, Funda Orhan, Anna Malmqvist, Fredrik Piehl, Simon Cervenka, Carl M. Sellgren, Helena Fatouros-Bergman, Goran Engberg, Sophie Erhardt
Summary: In this study, immune aberrations in schizophrenia were investigated by analyzing a large number of immune-related proteins. It was found that several inflammatory proteins were significantly elevated in the plasma of both first-episode psychosis patients and schizophrenia patients, and these elevations were associated with disease severity. However, only CD5 showed a difference in cerebrospinal fluid.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Bruce K. Patterson, Jose Guevara-Coto, Ram Yogendra, Edgar B. Francisco, Emily Long, Amruta Pise, Hallison Rodrigues, Purvi Parikh, Javier Mora, Rodrigo A. Mora-Rodriguez
Summary: CCR5 and its ligands play a role in COVID-19 pathogenesis, with a focus on immune responses. Elevated B-cells and certain monocytic subsets were observed in COVID-19 patients, while certain T-cell subsets were decreased compared to healthy controls. Various cytokines showed significantly different levels in COVID-19 patients compared to healthy controls, indicating immune dysregulation in the disease process.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Ahmed Ahmed Touni, Rohan S. Shivde, Harika Echuri, Rasha T. A. Abdel-Aziz, Hossam Abdel-Wahab, Roopal V. Kundu, I. Caroline Le Poole
Summary: Vitiligo is a common skin disorder characterized by the progressive loss of melanocytes. Keratinocytes, which are closely associated with melanocytes, play a crucial role in maintaining melanocyte function and homeostasis. Dysfunctional keratinocytes contribute to melanocyte loss through apoptosis, impairment of adhesion, presentation of melanocyte antigens, and recruitment of inflammatory T cells. Keratinocytes also fail to produce essential factors for melanocyte survival and interfere with repigmentation. Therefore, keratinocyte dysfunction is implicated in the development of vitiligo.
FRONTIERS IN MEDICINE
(2023)
Article
Allergy
Bo L. Chawes, Helene M. Wolsk, Christian J. Carlsson, Morten A. Rasmussen, Nilofar Folsgaard, Jakob Stokholm, Klaus Bonnelykke, Susanne Brix, Ann-Marie M. Schoos, Hans Bisgaard
Summary: The study analyzed the relationship between airway immune composition in 620 healthy one-month-old newborns and childhood allergies and asthma. It found that specific airway immune profiles were associated with elevated specific IgE to allergens, positive skin prick tests, and allergic rhinitis in early childhood.
Review
Medical Laboratory Technology
Priyanila Magesh, Sanu Thankachan, Thejaswini Venkatesh, Padmanaban S. Suresh
Summary: The fibroblasts in the breast tumor microenvironment are crucial for tumor progression and metastasis, as they provide energy to adjacent cancer cells through metabolic reprogramming and secrete growth factors to promote tumor growth and dissemination. Identifying effective strategies to target the reprogrammed metabolism and communication between fibroblasts and cancer cells could lead to promising anti-cancer therapeutics.
CLINICA CHIMICA ACTA
(2021)
Review
Medicine, General & Internal
Timothy J. Kopper, Xiaoli Yu, Michael W. Graner
Summary: Glioblastomas (GBM) is a devastating disease with poor clinical outcomes. Tumor-derived extracellular vesicles (EVs) impair macrophage function and promote tumor growth. The interaction between macrophages/microglia and gliomas plays a significant role in GBM pathophysiology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Tong Yue, Yu Shi, Sihui Luo, Jianping Weng, Yali Wu, Xueying Zheng
Summary: Diabetic retinopathy is a common complication of diabetes mellitus that is largely driven by inflammation. Understanding and elucidating the inflammation-related mechanisms is crucial for prevention and management of diabetic retinopathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Akitoshi Hara, Michelle D. Tallquist
Summary: The intricate interplay between inflammatory and reparative responses in the context of heart injury is central to the pathogenesis of heart failure. Recent studies have focused on the interplay between fibroblasts and immune cells, bringing us closer to the identification of cell type-specific targets for intervention.
CURRENT CARDIOLOGY REPORTS
(2023)
Article
Dermatology
Ling-Hong Zhou, Hua-Zhen Zhao, Xuan Wang, Rui-Ying Wang, Ying-Kui Jiang, Li-Ping Huang, Ching-Wan Yip, Jia-Hui Cheng, Chun-Xing Que, Li-Ping Zhu
Summary: The study found an incidence rate of 10.9% for IRIS in non-HIV CM patients, with high CrAg titres associated with IRIS occurrence. The IRIS group had significantly higher baseline CSF cytokines levels, indicating a severe host immune inflammation response. LTA4H polymorphisms may influence IRIS pathogenesis by regulating baseline CSF MCP-1 levels.
Article
Multidisciplinary Sciences
Abhijeet P. Deshmukh, Suhas V. Vasaikar, Katarzyna Tomczak, Shubham Tripathi, Petra den Hollander, Emre Arslan, Priyanka Chakraborty, Rama Soundararajan, Mohit Kumar Jolly, Kunal Rai, Herbert Levine, Sendurai A. Mani
Summary: This study identified the complexity of the EMT process by analyzing gene expression profiles during EMT progression. It demonstrated that NOTCH signaling pathway drives TGF-beta-induced EMT, and gene signatures corresponding to intermediate hybrid EMT state are associated with poor patient outcome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Gloria Orlando, Barbara Molon, Antonella Viola, Mauro Alaibac, Roberta Angioni, Stefano Piaserico
Summary: Psoriasis is a chronic inflammatory skin disease associated with various comorbidities, including cardiovascular diseases. Current research focuses on the pathways linking psoriatic plaques to the cardiovascular system, as well as the potential involvement of endothelial cells in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Pietro Ghezzi, Vincent Jaquet, Fabrizio Marcucci, Harald H. H. W. Schmidt
BRITISH JOURNAL OF PHARMACOLOGY
(2017)
Article
Infectious Diseases
M. Zuin, C. Caserta, L. Roman, A. Mele, A. Zanetti, R. Cannatelli, A. Giorgini, C. Tagliacarne, A. Amante, F. Marcucci, P. M. Battezzati
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2017)
Review
Biochemistry & Molecular Biology
Fabrizio Marcucci, Pietro Ghezzi, Cristiano Rumio
Review
Physiology
Angelo Corti, Fabrizio Marcucci, Tiziana Bachetti
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2018)
Review
Pharmacology & Pharmacy
Fabrizio Marcucci, Cristiano Rumio
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Oncology
Alice Dallatomasina, Anna Maria Gasparri, Barbara Colombo, Angelina Sacchi, Mimma Bianco, Tiziana Daniele, Antonio Esposito, Fabio Pastorino, Mirco Ponzoni, Fabrizio Marcucci, Flavio Curnis, Angelo Corti
Editorial Material
Respiratory System
Fabrizio Marcucci, Cristiano Rumio
JOURNAL OF THORACIC DISEASE
(2019)
Review
Oncology
Fabrizio Marcucci, Carmelo Antonio Caserta, Elisabetta Romeo, Cristiano Rumio
FRONTIERS IN ONCOLOGY
(2019)
Review
Pharmacology & Pharmacy
Fabrizio Marcucci, Elisabetta Romeo, Carmelo A. Caserta, Cristiano Rumio, Francois Lefoulon
TRENDS IN PHARMACOLOGICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Fabrizio Marcucci, Cristiano Rumio
Summary: Adaptive antitumor immune responses can sometimes promote tumor growth by causing expansion, resistance, proliferation, etc. Understanding these immune responses may help predict and counteract hyperprogressive diseases, suggesting the need for predictive biomarkers and therapeutic interventions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Fabrizio Marcucci, Cristiano Rumio
Summary: There is ample evidence that glycolysis can induce epithelial-mesenchymal transition (EMT) and autophagy in tumor cells. Furthermore, upregulation of glycolysis can result in a mixed mesenchymal/autophagic phenotype in tumor cells.
Review
Cell Biology
Fabrizio Marcucci, Cristiano Rumio
Summary: Reprogramming of energy production from mitochondrial respiration to glycolysis is a characteristic of cancer. Glycolysis can be upregulated in the early stages of tumorigenesis, as many oncoproteins involved in tumor initiation and progression promote glycolysis. In addition, recent evidence suggests that upregulated glycolysis itself may contribute to tumorigenesis through various mechanisms. This article provides a summary of the role of upregulated glycolysis in tumor initiation and proposes a mechanistic model to explain its involvement.
Review
Biochemistry & Molecular Biology
Fabrizio Marcucci, Cristiano Rumio, Angelo Corti
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2017)
Article
Public, Environmental & Occupational Health
Carmelo Antonio Caserta, Alfonso Mele, Pasquale Surace, Luigina Ferrigno, Angela Amante, Arianna Messineo, Carmelo Vacalebre, Fulvia Amato, Damiano Baldassarre, Mauro Amato, Fabrizio Marcucci, Massimo Zuin
ANNALI DELL ISTITUTO SUPERIORE DI SANITA
(2017)