Article
Biotechnology & Applied Microbiology
Guang-Cheng Luo, Lin Chen, Jiang Fang, Zhi-Jian Yan
Summary: This study revealed that hsa_circ_0030586 is significantly upregulated in prostate cancer cells and may promote epithelial-mesenchymal transition (EMT) through the PI3K-AKT signaling pathway. Experiment results showed that interfering with hsa_circ_0030586 could inhibit tumor cell proliferation, migration, and invasion in PCa.
Article
Multidisciplinary Sciences
Gerhard A. Burger, Daphne N. Nesenberend, Carlijn M. Lems, Sander C. Hille, Joost B. Beltman
Summary: Epithelial-mesenchymal transition (EMT) and upregulation of programmed death-ligand 1 (PD-L1) play crucial roles in cancer progression, but their molecular interaction remains unclear. In this study, a mathematical model was proposed to describe the crosstalk between EMT and interferon gamma (IFN gamma)-induced PD-L1 expression. The model revealed that microRNA-200 (miR-200) regulates the stability of the EMT circuit and PD-L1 levels, which are further enhanced by IFN gamma. This bidirectional crosstalk also suggests that IFN gamma promotes EMT and inhibits mesenchymal-epithelial transition (MET). Overall, this model provides insights into the mechanisms underlying EMT-mediated immune evasion and resistance to immunotherapy.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Biotechnology & Applied Microbiology
Xiaoqiang Hu, Junzhe Zhang, Junfeng Bu, Kaini Yang, Sunwang Xu, Mengqiao Pan, Dongxi Xiang, Wei Chen
Summary: This study identified the upregulation of miR-4733-5p and the downregulation of KLF7 in GBC, and demonstrated that miR-4733-5p promotes GBC cell proliferation by directly binding to the 3'UTR of KLF7. The downregulation of KLF7 inhibited GBC cell proliferation and migration.
Article
Oncology
Shelan Rasool, Qais Al Ismaeel, Srdar H. Arif
Summary: This study investigated the expression pattern of matricellular proteins SPARC and CYR61 in colorectal cancer and found their association with cancer progression. High expression of CYR61 was associated with migration, invasion, proliferation, and apoptosis of colorectal cancer cells. This discovery provides new insights for the treatment of colorectal cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yao Li, Quan Li, Dujian Li, Jie Gu, Duocheng Qian, Xiaojing Qin, Yu Chen
Summary: The study found that exosomal PSGR promoted migration, invasion, stemness, and epithelial-mesenchymal transitions of prostate cancer cells, and reshaped the mRNA profiles of the cells.
Article
Biochemistry & Molecular Biology
Janae D. Sweeney, Marija Debeljak, Stacy Riel, Ana Cecilia Millena, James R. Eshleman, Channing J. Paller, Valerie Odero-Marah
Summary: The research showed that SOD2 expression did not correlate with tumor aggressiveness or SOD2 genotype in prostate cancer. However, the Ala-SOD2 allele may promote EMT, leading to increased cell migration. The antioxidant MSKE could inhibit EMT mediated by Ala-SOD2 SNP, indicating promising therapeutic potential for halting prostate cancer progression.
Review
Biochemistry & Molecular Biology
Fu Peng, Huali Fan, Sui Li, Cheng Peng, Xiaoqi Pan
Summary: MicroRNAs have been utilized as negative regulators in cancer treatment by down-regulating their targets, especially in the EMT process. Natural plant compounds can modulate deregulated microRNAs to inhibit EMT, which could potentially lead to the inhibition of cancer development. This review article highlights the significance of microRNAs in EMT as oncogenes and tumor suppressor genes, providing evidence for target therapy in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ana Pavlic, Kristian Urh, Katarina Stajer, Emanuela Bostjancic, Nina Zidar
Summary: The study analyzed the expression of the miR-200 family as EMT markers and their target genes in colorectal carcinoma. It found partial EMT at the invasive tumor front and partial MET in metastases based on miR-200 family and its target genes expression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Allergy
Mingyu Lee, Suha Lim, Yi Sook Kim, Roza Khalmuratova, Seung-Hyun Shin, Iljin Kim, Hyun-Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Jong-Wan Park, Hyun-Woo Shin
Summary: Exposure to diesel exhaust particles (DEP) may promote nasal polyposis through the induction of epithelial-to-mesenchymal transition (EMT). ZEB2 may be a therapeutic target for DEP-induced epithelial damage and related airway diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yu Fan, Tu-Run Song, Qiang Wei, Lu Yang, Tao Lin, Xiao-Bing Feng, Xian-Ding Wang, Zhong-Li Huang, Shi-Jian Feng
Summary: Estrogen plays a role in the development of benign prostatic hyperplasia (BPH) through promoting AQP5 expression and subsequent epithelial-mesenchymal transition (EMT) in prostate cells. This study found that BPH tissues had higher AQP5 expression and EMT levels compared to normal prostate tissues. Estrogen-stimulated cells had increased AQP5 expression, cell proliferation, and EMT, which could be partially reversed by AQP5 knockdown.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Binshen Chen, Yiming Zhang, Chaoming Li, Peng Xu, Yubo Gao, Yawen Xu
Summary: The study revealed that downregulation of CNTN-1 can reverse multi-drug resistance to docetaxel in prostate cancer, reducing cell proliferation, migration, invasion, increasing apoptosis, and inhibiting the activity of the phosphoinositide 3-kinase signaling pathway.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Immunology
Junwei Zhao, Tianci Jiang, Pengfei Li, Lingling Dai, Guang Shi, Xiaogang Jing, Shuhui Gao, Liuqun Jia, Shujun Wu, Yu Wang, Youmei Peng, Zhe Cheng
Summary: The study showed that TF promotes airway pathological features by enhancing the EMT of bronchial epithelial cells in asthma, while downregulation of TF reduces airway hyperresponsiveness, eosinophil inflammation, and EMT process. TF downregulation also inhibits migration and invasion, and decreases fibronectin 1 and TGF-β1 expression while increasing E-cadherin expression in stimulated 16HBE cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Bingfeng Luo, Yuan Yuan, Yifei Zhu, Songwu Liang, Runan Dong, Jian Hou, Ping Li, Yaping Xing, Zhenquan Lu, Richard Lo, Guan-Ming Kuang
Summary: miRNA-145-5p was found to negatively regulate EMT, inhibit Pca bone metastasis, and promote apoptosis. It may serve as a potential target for treating Pca with bone metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang, Xiangbo Xu
Summary: The study revealed that the overexpression of CHN1 is associated with lymph node metastasis and low survival rates in cervical carcinoma patients. CHN1 overexpression promoted cell proliferation, migration, and invasion by inducing EMT-related transcription factors. Furthermore, in vitro experiments showed that CHN1 overexpression activated the Akt/GSK-3 beta/Snail signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Jou-Chun Chou, Fu-Kong Lieu, Donald Ming-Tak Ho, Heng-Yi Shen, Po-Han Lin, Sindy Hu, Shyi-Wu Wang, Ho Lin, Paulus S. Wang
Summary: This study revealed that PRL promotes NSCLC cell proliferation by upregulating GHR and JAK2/STAT3/VEGF pathway. NSCLC cells secrete PRL and GHR is the key receptor for PRL-induced cell proliferation.
Correction
Environmental Sciences
Jou-Chun Chou, Fu-Kong Lieu, Donald Ming-Tak Ho, Heng-Yi Shen, Po-Han Lin, Sindy Hu, Shyi-Wu Wang, Ho Lin, Paulus S. Wang
Article
Multidisciplinary Sciences
Eileen M. Boyle, Shayu Deshpande, Ruslana Tytarenko, Cody Ashby, Yan Wang, Michael A. Bauer, Sarah K. Johnson, Christopher P. Wardell, Sharmilan Thanendrarajan, Maurizio Zangari, Thierry Facon, Charles Dumontet, Bart Barlogie, Arnaldo Arbini, Even H. Rustad, Francesco Maura, Ola Landgren, Fenghuang Zhan, Frits van Rhee, Carolina Schinke, Faith E. Davies, Gareth J. Morgan, Brian A. Walker
Summary: The study found that smoldering myeloma (SMM) has fewer NRAS and FAM46C mutations, as well as fewer adverse translocations, when compared to newly diagnosed myeloma. KRAS mutations are associated with a shorter time to progression. Changes in clonal structure, branching evolutionary patterns, and other genetic mechanisms may underlie the transition from SMM to MM, providing insights for early intervention strategies.
NATURE COMMUNICATIONS
(2021)
Letter
Clinical Neurology
I. Kister, I. Lotan, A. Wallach, T. Bacon, G. Cutter, A. Arbini
Summary: Multiparametric flow cytometry of CSF can estimate the percentage of lymphocyte subpopulations easily. The increased ratio of B-lineage cells in CSF of MS patients could be a useful diagnostic factor. Analysis of CSF showed that plasmablasts of >0.25% had higher specificity in diagnosing MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Yu-An Chen, Yi-Ru Lai, Hui-Yu Wu, Yen-Ju Lo, Yu-Fang Chang, Chiu-Lien Hung, Chun-Jung Lin, U-Ging Lo, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Yu-Hsin Lin, Chih-Ho Lai
Summary: The study identified HA-CdtB-NPs as a promising targeted therapy against radioresistant PCa cells, enhancing DNA double-strand breaks and inducing cell-cycle arrest to increase cell sensitivity. These nanoparticles demonstrate maximum target specificity and delivery efficiency, enhancing the radiation effect in radioresistant PCa cells. Their target specificity and radiomimetic activity suggest that they could be developed as an effective strategy against radioresistant PCa.
Article
Multidisciplinary Sciences
Daniele Simoneschi, Gergely Rona, Nan Zhou, Yeon-Tae Jeong, Shaowen Jiang, Giacomo Milletti, Arnaldo A. Arbini, Alfie O'Sullivan, Andrew A. Wang, Sorasicha Nithikasem, Sarah Keegan, Yik Siu, Valentina Cianfanelli, Emiliano Maiani, Francesca Nazio, Francesco Cecconi, Francesco Boccalatte, David Fenyo, Drew R. Jones, Luca Busino, Michele Pagano
Summary: The research identifies AMBRA1 as a ubiquitin ligase that degrades D-type cyclins, whose loss leads to accumulation of D-type cyclins and tumorigenesis. Furthermore, AMBRA1 also affects the sensitivity to CDK4/6 inhibitors.
Article
Oncology
Eileen M. Boyle, Louis Williams, Patrick Blaney, Cody Ashby, Michael Bauer, Brian A. Walker, Hussein Ghamlouch, Jinyoung Choi, Emeline Perrial, Yubao Wang, Jessica Caro, James H. Stoeckle, Arnaldo Arbini, David Kaminetzky, Marc Braunstein, Benedetto Bruno, Beatrice Razzo, Benjamin Diamond, Kylee Maclachlan, Francesco Maura, Ola Landgren, Rachel Litke, Christopher D. Fegan, Johnathan Keats, Daniel Auclair, Faith E. Davies, Gareth J. Morgan
Article
Oncology
Cheng-Fan Lee, Yu-An Chen, Elizabeth Hernandez, Rey-Chen Pong, Shihong Ma, Mia Hofstad, Payal Kapur, Haiyen Zhau, Leland W. K. Chung, Chih-Ho Lai, Ho Lin, Ming-Shyue Lee, Ganesh Raj, Jer-Tsong Hsieh
Summary: This study reveals the important role of SphK1 in NEPC development, providing a new target for the treatment of NEPC using SphK1 inhibitors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Bo-Ren Wang, Yu-An Chen, Wei-Hsiang Kao, Chih-Ho Lai, Ho Lin, Jer-Tsong Hsieh
Summary: Prostate cancer is a common cancer among men, and a significant percentage of patients develop metastatic prostate cancer. Treating castration-resistant prostate cancer (CRPC) is challenging, but recent research has identified new anti-androgen agents and targeting drugs that can prolong the survival of CRPC patients.
Article
Integrative & Complementary Medicine
Chieh-Yin Chen, Yu-Hsuan Li, Wan-Ling Liao, Muhammet Oner, Yu-Chiao Cheng, Fang-Ling Liu, Pang-Ting Cheng, Ayse Celik, Jyh-Horng Wu, Chih-Ho Lai, Jer-Tsong Hsieh, Ho Lin, Ting-Chieh Chang, Chih-Ying Chang, Mei-Chih Chen
Summary: Antrodia salmonea extracts inhibit the proliferation of prostate cancer cells and induce apoptosis through the reverse regulation of p53 and androgen receptor (AR), suggesting their potential therapeutic use for androgen-dependent prostate cancer.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Immunology
Ngoc-Niem Bui, Chen-Yi Li, Ling-Yu Wang, Yu-An Chen, Wei-Hsiang Kao, Li-Fang Chou, Jer-Tsong Hsieh, Ho Lin, Chih-Ho Lai
Summary: Prostate cancer is a common malignancy in men, and its mortality has been increasing globally. This study investigated the effect of C. scindens, a member of the gut microbiota, on the progression of prostate cancer. The results showed that metabolites derived from C. scindens promoted the proliferation and migration of prostate cancer cells, accompanied by the activation of the androgen receptor (AR). These findings suggest that C. scindens may contribute to prostate cancer progression via the activation of AR signaling.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Po-Hsin Lee, Yen-Hsiang Huang, Yu-Wei Hsu, Kun-Chieh Chen, Kuo-Hsuan Hsu, Ho Lin, Teng-Yu Lee, Jeng-Sen Tseng, Gee-Chen Chang, Tsung-Ying Yang
Summary: This study evaluated the risk of HBV reactivation in lung cancer patients treated with TKI, particularly in those with resolved HBV infection. The results showed that HBsAg-positive TKI users had a higher risk of HBV reactivation, and NUC prophylaxis is recommended. In patients with resolved HBV infection, the risk is lower, and regular monitoring is recommended.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Pang-Ting Cheng, Yu-Chiao Cheng, Muhammet Oner, Yu-Hsuan Li, Mei-Chih Chen, Jyh-Horng Wu, Ting-Chieh Chang, Ayse Celik, Fang-Ling Liu, Hsin-Yi Wang, Chih-Ho Lai, Jer-Tsong Hsieh, Chieh-Yin Chen, Ho Lin
Summary: The study found that Antrodia salmonea can inhibit the proliferation of prostate cancer cells by regulating the cell cycle and apoptosis pathways.
CHINESE JOURNAL OF PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Po-Hsin Lee, Yen-Hsiang Huang, Ho Lin, Kuo-Hsuan Hsu, Kun-Chieh Chen, Jeng-Sen Tseng, Gee-Chen Chang, Tsung-Ying Yang
Summary: This study aimed to investigate the incidence of histological transformation and its impact on treatment outcomes in patients with EGFR-mutant lung adenocarcinoma receiving third-generation EGFR-TKI therapy. The results revealed that a subset of patients experienced histological transformation, which rendered the treatment ineffective and was associated with shorter overall survival. Therefore, repeating biopsy to identify histological transformation should be considered to guide treatment decisions.
MEDICINA-LITHUANIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Su-Tang Lo, Daniel Parrott, M. Veronica Clavijo Jordan, Diya Binoy Joseph, Douglas Strand, U-Ging Lo, Ho Lin, Anza Darehshouri, A. Dean Sherry
Summary: Fluorescent studies demonstrate that ZnT1 is the major zinc efflux transporter in prostate epithelial cells, and loss of ZnT1 via mRNA knockdown combined with lysosomal storage disruption leads to a significant increase in cytosolic zinc. Knockdown of ZnT1 dramatically reduces zinc efflux during glucose-stimulated zinc secretion. Electron microscopy shows that glucose stimulation increases lysosomal storage of zinc, and disruption of lysosomes via Baf or ZnT4 mRNA knockdown results in increased multi-vesicular body formation and cytosolic zinc levels. In human BPH tissue, only the luminal epithelial cells contain significant zinc storage granules.
MOLECULAR IMAGING AND BIOLOGY
(2021)