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Title
The genetics of drug efficacy: opportunities and challenges
Authors
Keywords
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Journal
NATURE REVIEWS GENETICS
Volume 17, Issue 4, Pages 197-206
Publisher
Springer Nature
Online
2016-03-14
DOI
10.1038/nrg.2016.12
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Note: Only part of the references are listed.- Different effects of the BIM deletion polymorphism on treatment of solid tumors by the tyrosine kinase inhibitors (TKI) pazopanib, sunitinib, and lapatinib
- (2015) C. F. Spraggs et al. ANNALS OF ONCOLOGY
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- (2015) C-F Xu et al. BRITISH JOURNAL OF CANCER
- High response rates to neoadjuvant platinum-based therapy in ovarian cancer patients carrying germ-line BRCA mutation
- (2015) Tatiana V. Gorodnova et al. CANCER LETTERS
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- (2015) Pasi Soininen et al. Circulation-Cardiovascular Genetics
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- (2015) Susannah L. Collins et al. DRUG SAFETY
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- (2015) F Ehmann et al. PHARMACOGENOMICS JOURNAL
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- (2014) Jonathan Ledermann et al. LANCET ONCOLOGY
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- (2014) S Tiong Ong et al. NATURE MEDICINE
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- (2014) Jun-ichi Nishimura et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic architecture of pharmacological efficacy and adverse events
- (2014) Aparna Chhibber et al. PHARMACOGENOMICS
- A Bayesian Method to Incorporate Hundreds of Functional Characteristics with Association Evidence to Improve Variant Prioritization
- (2014) Sarah A. Gagliano et al. PLoS One
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
- (2014) Iris Postmus et al. Nature Communications
- Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies
- (2014) Gleb Kichaev et al. PLoS Genetics
- Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines
- (2014) Paul Geeleher et al. GENOME BIOLOGY
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- (2014) D. Colquhoun Royal Society Open Science
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- (2013) John P.A. Ioannidis Circulation-Cardiovascular Genetics
- CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations
- (2013) M A Province et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
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- (2013) W-Q Wei et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study
- (2013) Minoli A Perera et al. LANCET
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
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- (2013) Issam Zineh et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Randomized Trial of Genotype-Guided Dosing of Warfarin
- (2013) Munir Pirmohamed et al. NEW ENGLAND JOURNAL OF MEDICINE
- The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
- (2013) Danielle Welter et al. NUCLEIC ACIDS RESEARCH
- Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment
- (2013) Louise A. Donnelly et al. Pharmacogenetics and Genomics
- Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent
- (2013) F Aminkeng et al. PHARMACOGENOMICS JOURNAL
- The pharmacogenomics of statins
- (2013) Ingrid C. Gelissen et al. PHARMACOLOGICAL RESEARCH
- Towards the identification of imaging biomarkers in schizophrenia, using multivariate pattern classification at a single-subject level
- (2013) Eleni Zarogianni et al. NeuroImage-Clinical
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
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- (2012) Jeffrey L. Anderson et al. CIRCULATION
- Genetic Determinants of Statin-Induced Low-Density Lipoprotein Cholesterol Reduction
- (2012) Daniel I. Chasman et al. Circulation-Cardiovascular Genetics
- Beyond Diagnostic Accuracy: The Clinical Utility of Diagnostic Tests
- (2012) P. M. M. Bossuyt et al. CLINICAL CHEMISTRY
- Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer
- (2012) Kelly L. Bolton JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
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- (2012) Kathryn Alsop et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Harshal A. Deshmukh et al. JOURNAL OF LIPID RESEARCH
- Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial
- (2012) Jason D Roberts et al. LANCET
- What makes UK Biobank special?
- (2012) Rory Collins LANCET
- Zhou et al. reply
- (2012) Kaixin Zhou et al. NATURE GENETICS
- A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
- (2012) King Pan Ng et al. NATURE MEDICINE
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- (2012) Thomas R. Fleming et al. STATISTICS IN MEDICINE
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- (2011) M A Franc et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
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- (2011) R A Wilke et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
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- (2011) J T Delaney et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
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- (2011) A. C. Faber et al. Cancer Discovery
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- (2010) Joel Greshock et al. CANCER RESEARCH
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- (2010) Hana Lango Allen et al. NATURE
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- (2010) Kaixin Zhou et al. NATURE GENETICS
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- A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose
- (2009) Fumihiko Takeuchi et al. PLoS Genetics
- Community consultation and communication for a population-based DNA biobank: The Marshfield clinic personalized medicine research project
- (2008) Catherine A. McCarty et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
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- (2008) DM Roden et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges
- (2008) Mark I. McCarthy et al. NATURE REVIEWS GENETICS
- HLA-B*5701 Screening for Hypersensitivity to Abacavir
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- Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease
- (2008) Tuomo Nieminen et al. PHARMACOGENOMICS
- Clinical implications of a molecular genetic classification of monogenic β-cell diabetes
- (2008) Rinki Murphy et al. Nature clinical practice. Endocrinology & metabolism
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