Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin

Twist1 regulates Vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma

(2018) Jing Meng et al.   CANCER RESEARCH

Depletion of keratin 8/18 modulates oncogenic potential by governing multiple signaling pathways

(2018) Richa Tiwari et al.   FEBS Journal

Intermediate filaments control collective migration by restricting traction forces and sustaining cell–cell contacts

(2018) Chiara De Pascalis et al.   JOURNAL OF CELL BIOLOGY

Complexes of α6β4 integrin and vimentin signal to regulate epithelial cell migration

(2018) Zachary T. Colburn et al.   JOURNAL OF CELL SCIENCE

Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis

(2018) William P. Bozza et al.   Oncotarget

Cytoplasmic Intermediate Filaments in Cell Biology

(2018) Sandrine Etienne-Manneville   Annual Review of Cell and Developmental Biology

Keratin 80 promotes migration and invasion of colorectal carcinoma by interacting with PRKDC via activating the AKT pathway

(2018) Changcan Li et al.   Cell Death & Disease

Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

(2018) Yanan Zhang et al.   Nature Communications

Vimentin Diversity in Health and Disease

(2018) Frida Danielsson et al.   Cells

TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway

(2017) Lanfang Wu et al.   FEBS Journal

The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin

(2017) Lei Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma

(2017) O Govaere et al.   ONCOGENE

Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma

(2017) Xiao-lei Gao et al.   PLoS One

Prognostic significance of cytokeratin 19 expression in pancreatic neuroendocrine tumor: A meta-analysis

(2017) Dong Cen et al.   PLoS One

Selective regulation of Notch ligands during angiogenesis is mediated by vimentin

(2017) Daniel Antfolk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth

(2017) Ningning Zhang et al.   Cell Death & Disease

KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma

(2017) Hai-Song Tan et al.   Oncotarget

Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer

(2017) Kristi Krüger et al.   Scientific Reports

Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis

(2016) Masato Takano et al.   BMC CANCER

Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway

(2016) Julia O. Misiorek et al.   CARCINOGENESIS

Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver

(2016) Nam-On Ku et al.   HEPATOLOGY

Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape

(2016) Malte Mohme et al.   Nature Reviews Clinical Oncology

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo

(2016) R P Hobbs et al.   ONCOGENE

Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

(2016) Z Zelenko et al.   ONCOGENE

KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties

(2016) S K Saha et al.   ONCOGENE

Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling

(2016) Fang Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermediate Filaments: Structure and Assembly

(2016) Harald Herrmann et al.   Cold Spring Harbor Perspectives in Biology

USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells

(2016) Ying Zhu et al.   Oncotarget

Epithelial cell migration requires the interaction between the vimentin and keratin intermediate filaments

(2016) Cristina Velez-delValle et al.   Scientific Reports

Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71

(2015) Yoko Matsuda et al.   CANCER LETTERS

Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility

(2015) L. F. Escobar-Hoyos et al.   CANCER RESEARCH

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

(2015) Reetta Virtakoivu et al.   CANCER RESEARCH

Nestin as a marker of cancer stem cells

(2015) Jakub Neradil et al.   CANCER SCIENCE

Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

(2015) Samuel Asfaha et al.   Cell Stem Cell

Keratins in health and disease

(2015) Diana M Toivola et al.   CURRENT OPINION IN CELL BIOLOGY

Intermediate filaments in cell migration and invasion: the unusual suspects

(2015) Cécile Leduc et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes

(2015) Byung Min Chung et al.   JOURNAL OF CELL BIOLOGY

Microtubule-dependent transport and dynamics of vimentin intermediate filaments

(2015) Caroline Hookway et al.   MOLECULAR BIOLOGY OF THE CELL

Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes

(2015) Ryan P Hobbs et al.   NATURE GENETICS

CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer

(2015) Ming T. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vimentin regulates activation of the NLRP3 inflammasome

(2015) Gimena dos Santos et al.   Nature Communications

Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes

(2015) Divya Bhagirath et al.   Oncotarget

Nestin Delineates Pancreatic Cancer Stem Cells in Metastatic Foci of NOD/Shi-scid IL2Rγnull (NOG) Mice

(2014) Yoko Matsuda et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer

(2014) A. Nagalingam et al.   CANCER RESEARCH

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

(2014) Darjus F. Tschaharganeh et al.   CELL

Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes

(2014) J-h Ju et al.   CELL DEATH AND DIFFERENTIATION

Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin

(2014) Mei Ming et al.   EXPERIMENTAL DERMATOLOGY

Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma

(2014) KOSUKE NARITA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Keratin 19 expression correlates with poor prognosis in breast cancer

(2014) Nuzhat N. Kabir et al.   MOLECULAR BIOLOGY REPORTS

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

(2014) Antonina V. Kurtova et al.   NATURE

Post-translational modifications of intermediate filament proteins: mechanisms and functions

(2014) Natasha T. Snider et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vimentin regulates lung cancer cell adhesion through a VAV2–Rac1 pathway to control focal adhesion kinase activity

(2014) L S Havel et al.   ONCOGENE

Role of the Stem Cell-Associated Intermediate Filament Nestin in Malignant Proliferation of Non-Small Cell Lung Cancer

(2014) Zhenguang Chen et al.   PLoS One

A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER-Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation

(2014) Chiung-Hui Fu et al.   STEM CELLS

Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma

(2014) J Ma et al.   Cell Death & Disease

A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma

(2014) J Tang et al.   Cell Death & Disease

Nestin involvement in tissue injury and cancer - a potential tumor marker?

(2014) Ekaterini Christina Tampaki et al.   CELLULAR ONCOLOGY

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Regulation of Cell Proliferation and Migration by Keratin19-Induced Nuclear Import of Early Growth Response-1 in Breast Cancer Cells

(2013) J.-h. Ju et al.   CLINICAL CANCER RESEARCH

Networking galore: intermediate filaments and cell migration

(2013) Byung-Min Chung et al.   CURRENT OPINION IN CELL BIOLOGY

Proteomic Profiling of Endothelial Invasion Revealed Receptor for Activated C Kinase 1 (RACK1) Complexed with Vimentin to Regulate Focal Adhesion Kinase (FAK)

(2013) Jui M. Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratin 8 and 18 Loss in Epithelial Cancer Cells Increases Collective Cell Migration and Cisplatin Sensitivity through Claudin1 Up-regulation

(2013) Anne-Marie Fortier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A

(2013) Fiorenza Lotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Keratin 17: A Critical Player in the Pathogenesis of Psoriasis

(2013) Liang Jin et al.   MEDICINAL RESEARCH REVIEWS

A Novel Role for Keratin 17 in Coordinating Oncogenic Transformation and Cellular Adhesion in Ewing Sarcoma

(2013) Savita Sankar et al.   MOLECULAR AND CELLULAR BIOLOGY

Mesenchymal phenotype after chemotherapy is associated with chemoresistance and poor clinical outcome in esophageal cancer

(2013) JOHJI HARA et al.   ONCOLOGY REPORTS

Keratin 16 regulates innate immunity in response to epidermal barrier breach

(2013) J. C. Lessard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keratins significantly contribute to cell stiffness and impact invasive behavior

(2013) K. Seltmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nestin: A novel angiogenesis marker and possible target for tumor angiogenesis

(2013) Yoko Matsuda   WORLD JOURNAL OF GASTROENTEROLOGY

Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation

(2012) Hyeong-Il Kwak et al.   ANGIOGENESIS

The expanding significance of keratin intermediate filaments in normal and diseased epithelia

(2012) Xiaoou Pan et al.   CURRENT OPINION IN CELL BIOLOGY

Keratins

(2012) Pavel Strnad et al.   CURRENT OPINION IN GASTROENTEROLOGY

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair

(2012) Jeremy D. Rotty et al.   JOURNAL OF CELL BIOLOGY

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18

(2012) Wera Roth et al.   JOURNAL OF CELL SCIENCE

Nestin and other putative cancer stem cell markers in pancreatic cancer

(2012) Yoko Matsuda et al.   Medical Molecular Morphology

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Statistical Association of Basal Cell Keratins with Metastasis-Inducing Proteins in a Prognostically Unfavorable Group of Sporadic Breast Cancers

(2011) Suzete de Silva Rudland et al.   AMERICAN JOURNAL OF PATHOLOGY

Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice

(2011) Grace Ying Wang et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Vimentin in cancer and its potential as a molecular target for cancer therapy

(2011) Arun Satelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

mRNA and microRNA Expression Profiles in Circulating Tumor Cells and Primary Tumors of Metastatic Breast Cancer Patients

(2011) A. M. Sieuwerts et al.   CLINICAL CANCER RESEARCH

Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin 19 expression and a poor prognosis

(2011) Haeryoung Kim et al.   HEPATOLOGY

Nestin as a regulator of Cdk5 in differentiating myoblasts

(2011) Hanna-Mari Pallari et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of Keratin 8 Phosphorylation Leads to Increased Tumor Progression and Correlates with Clinico-Pathological Parameters of OSCC Patients

(2011) Hunain Alam et al.   PLoS One

Identifying the cellular origin of squamous skin tumors

(2011) G. Lapouge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the origins of Ras/p53-mediated squamous cell carcinoma

(2011) A. C. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of nuclear nestin localization in cell lines derived from neurogenic tumors

(2011) Olga Krupkova et al.   TUMOR BIOLOGY

Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis

(2011) Toshiyuki Ishiwata   WORLD JOURNAL OF GASTROENTEROLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Inducible expression of stem cell associated intermediate filament nestin reveals an important role in glioblastoma carcinogenesis

(2010) Wen Jing Lu et al.   INTERNATIONAL JOURNAL OF CANCER

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

Keratin 8/18 Modulation of Protein Kinase C-mediated Integrin-dependent Adhesion and Migration of Liver Epithelial Cells

(2010) François Bordeleau et al.   MOLECULAR BIOLOGY OF THE CELL

Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin

(2010) Daryle DePianto et al.   NATURE GENETICS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vimentin is a novel AKT1 target mediating motility and invasion

(2010) Q-S Zhu et al.   ONCOGENE

Keratins in health and cancer: more than mere epithelial cell markers

(2010) V Karantza   ONCOGENE

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

(2010) K Vuoriluoto et al.   ONCOGENE

EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cells in the Human Breast

(2010) O. W. Petersen et al.   Cold Spring Harbor Perspectives in Biology

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Cytokeratin 19 regulates endoplasmic reticulum stress and inhibits ERp29 expression via p38 MAPK/XBP-1 signaling in breast cancer cells

(2009) I Fon Bambang et al.   EXPERIMENTAL CELL RESEARCH

Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor

(2009) Preethi Vijayaraj et al.   JOURNAL OF CELL BIOLOGY

“IF-pathies”: a broad spectrum of intermediate filament–associated diseases

(2009) M. Bishr Omary   JOURNAL OF CLINICAL INVESTIGATION

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

New common variants affecting susceptibility to basal cell carcinoma

(2009) Simon N Stacey et al.   NATURE GENETICS

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

The human keratins: biology and pathology

(2008) Roland Moll et al.   HISTOCHEMISTRY AND CELL BIOLOGY