Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway

Keratins in health and disease

(2015) Diana M Toivola et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of keratin network organization

(2015) Fanny Loschke et al.   CURRENT OPINION IN CELL BIOLOGY

Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection

(2015) Melba Muñoz et al.   IMMUNITY

Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism

(2015) Terhi O. Helenius et al.   MOLECULAR BIOLOGY OF THE CELL

Diverse roles of STING-dependent signaling on the development of cancer

(2015) J Ahn et al.   ONCOGENE

Deciphering the crosstalk among IL-1 and IL-10 family cytokines in intestinal immunity

(2015) Paolo Manzanillo et al.   TRENDS IN IMMUNOLOGY

Vimentin regulates activation of the NLRP3 inflammasome

(2015) Gimena dos Santos et al.   Nature Communications

The Amount of Keratins Matters for Stress Protection of the Colonic Epithelium

(2015) M. Nadeem Asghar et al.   PLoS One

IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L

(2014) Ilona Kryczek et al.   IMMUNITY

Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL-22 binding protein

(2014) Naveena B. Janakiram et al.   MOLECULAR CARCINOGENESIS

An Efficient Genotyping Method for Genome-modified Animals and Human Cells Generated with CRISPR/Cas9 System

(2014) Xiaoxiao Zhu et al.   Scientific Reports

Higher Activity of the Inducible Nitric Oxide Synthase Contributes to Very Early Onset Inflammatory Bowel Disease

(2014) Sandeep S Dhillon et al.   Clinical and Translational Gastroenterology

IL-22 is related to development of human colon cancer by activation of STAT3

(2013) Runqiu Jiang et al.   BMC CANCER

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

(2013) J CJ Martin et al.   Mucosal Immunology

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Unique Gene Expression and MR T2 Relaxometry Patterns Define Chronic Murine Dextran Sodium Sulphate Colitis as a Model for Connective Tissue Changes in Human Crohn’s Disease

(2013) Christine Breynaert et al.   PLoS One

The expanding significance of keratin intermediate filaments in normal and diseased epithelia

(2012) Xiaoou Pan et al.   CURRENT OPINION IN CELL BIOLOGY

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18

(2012) Wera Roth et al.   JOURNAL OF CELL SCIENCE

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon

(2011) A. Habtezion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Method for Serial Tissue Processing and Parallel Analysis of Aberrant Crypt Morphology, Mucin Depletion, and Beta-Catenin Staining in an Experimental Model of Colon Carcinogenesis

(2010) John N McGinley et al.   BIOLOGICAL PROCEDURES ONLINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Animal models of IBD: linkage to human disease

(2010) Atsushi Mizoguchi et al.   CURRENT OPINION IN PHARMACOLOGY

Interleukin-22: A cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection

(2010) Ellen Witte et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer

(2010) Milan Lukas   DIGESTIVE DISEASES

Keratins in health and cancer: more than mere epithelial cell markers

(2010) V Karantza   ONCOGENE

Intermediate filaments take the heat as stress proteins

(2010) D.M. Toivola et al.   TRENDS IN CELL BIOLOGY

Cytokines as genetic modifiers in K5���/���mice and in human epidermolysis bullosa simplex

(2009) Wera Roth et al.   HUMAN MUTATION

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The human keratins: biology and pathology

(2008) Roland Moll et al.   HISTOCHEMISTRY AND CELL BIOLOGY