Article
Biochemistry & Molecular Biology
Weiwei Chen, Fei Wang, Xinyuan Yu, Jingjing Qi, Hongliang Dong, Bingjie Cui, Qian Zhang, Yan Wu, Jiajia An, Na Ni, Cuilan Liu, Yuchen Han, Shuo Zhang, Clemens A. Schmitt, Jiong Deng, Yong Yu, Jing Du
Summary: Non-coding RNA plays a crucial role in oncogenesis and stemness development in various cancers, including lung cancer. MIR31HG, a lncRNA, is significantly upregulated in lung cancer tissues and peripheral sera of patients, indicating a poor prognosis. Mechanistically, MIR31HG promotes stemness-associated malignant features of non-small cell lung cancer cells by modulating GLI2 expression via H3K4me and H3K27Ace modifications mediated by the WDR5/MLL3/P300 complex. In vivo studies showed that repression of MIR31HG attenuated tumor growth and distal organ metastasis, while its promotion encouraged cellular invasion in lung and liver tissues. Hence, MIR31HG has the potential to serve as a diagnostic indicator and therapeutic target for lung cancer patients.
Article
Biochemistry & Molecular Biology
Jia Hou, Wenyuan Li, Shirong Zhang, Deli Tan, Kejia Lv, Yue Zhu, Yuzhu Hou, Hui Guo, Lili Jiang
Summary: This study found that UHRF1 is overexpressed in small cell lung cancer (SCLC) and its high expression is associated with poor prognosis. Mechanistic studies revealed that UHRF1 promotes SCLC growth by modulating YAP1. Downregulation of UHRF1 enhances sensitivity to platinum-based chemotherapy and is correlated with a favorable prognosis. Therefore, UHRF1 can be used as a biomarker and potential therapeutic target for SCLC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Medicine, Research & Experimental
Shimaa M. Abou-Zeid, Amany I. Ahmed, Ashraf Awad, Wafaa A. Mohammed, Mohamed M. M. Metwally, Rafa Almeer, Mohamed M. Abdel-Daim, Samah R. Khalil
Summary: The study demonstrates that ethanolic extract of Moringa oleifera protects against Tilmicosin-induced nephrotoxicity in rats by its potent antioxidant and anti-inflammatory properties.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Marco Napoli, Sarah J. Wu, Bethanie L. Gore, Hussein Abbas, Kyubum Lee, Rahul Checker, Shilpa Dhar, Kimal Rajapakshe, Aik Choon Tan, Min Gyu Lee, Cristian Coarfa, Elsa R. Flores
Summary: Distinct lung stem cells regulated by increment Np63 play a role in the development of both lung adenocarcinoma and squamous cell carcinoma through the regulation of a common landscape of enhancer-associated genes, including BCL9L.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
MengYang Zhao, ZiBo Tang, YiJun Wang, JiaoJiao Ding, Ying Guo, Ning Zhang, TianHui Gao
Summary: miR-4507 is upregulated in non-small-cell lung cancer and activates the PI3K/AKT signal pathway by targeting TPS3, promoting proliferation and migration of lung cancer cells.
Article
Cell Biology
Ruping Wang, Sakeeb Khan, Guoning Liao, Yidi Wu, Dale D. Tang
Summary: This study found that nestin promotes the migration of smooth muscle cells by regulating Plk1 phosphorylation, which in turn regulates vimentin phosphorylation, the connection of vimentin filaments with paxillin, and focal adhesion assembly.
Article
Astronomy & Astrophysics
Xia Sun, Xiaoli Yan, Hongfei Liang, Zhike Xue, Jincheng Wang, Liheng Yang, Zhe Xu, Liping Yang, Yang Peng, Qiaoling Li, Zihan li, Xinsheng Zhang
Summary: In this study, observations from the New Vacuum Solar Telescope, the Solar Dynamics Observatory, and the Global Oscillation Network Group were used to investigate the formation process of a filament in NOAA active region 12765 from June 5 to 8, 2020. It was found that intermittent small-scale magnetic reconnection occurred at the northern part of the filament, showing characteristics of oscillatory reconnections. The reconnection process resulted in continuous material injections into the filament channel, with bidirectional inflow and outflow, current sheets, and bright cusp-shaped structures. The formation of the filament was attributed to direct material injection into the filament channel due to small-scale magnetic reconnections.
ASTROPHYSICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Kui Xiao, Shenggang Liu, Yijia Xiao, Yang Wang, Zhiruo Zhu, Yaohui Wang, De Tong, Jiehan Jiang
Summary: This study identified a miRNA, hsa-mir-30a, that is differentially expressed in NSCLC and mainly affects the disease by regulating the cell cycle and drug metabolism.
Article
Cell Biology
Ruijun Liu, Ruili Liu, Zhiyi Guo, Jianghao Ren, Jia Huang, Qingquan Luo, Qiang Tan
Summary: This study demonstrates the significance of KNTC1 in non-small-cell lung cancer by participating in the regulation of cell proliferation, migration, and invasion through the segregation of sister chromatids. The findings also suggest a positive association between KNTC1 depletion and PSMB8 expression. These findings indicate that KNTC1 may serve as a novel therapeutic target for non-small-cell lung cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huan Ma, Siyu Jiang, Yinan Yuan, Ji Li, Yizhuo Li, Yanping Lv, Tengjiao Du, Jingqian Guan, Xizi Jiang, Lei Tian, Qianqian Zheng, Lianhe Yang, Qingchang Li
Summary: RUNX1, a member of the RUNX family, is involved in the regulation of non-small cell lung cancer. It promotes cell proliferation and migration via the mTOR pathway and may serve as a potential therapeutic target for NSCLC.
Article
Biotechnology & Applied Microbiology
Ying Chen, Meilian Zhao, Dongliang Shen, Qian Yi, Liling Tang
Summary: SNF5 is overexpressed in non-small cell lung cancer (NSCLC), promoting tumor cell proliferation and immune evasion. It regulates immune evasion in NSCLC cells by activating the STAT3/phospho-STAT3 pathway.
Article
Oncology
Jedrzej Grzegrzolka, Mateusz Olbromski, Agnieszka Gomulkiewicz, Aleksandra Piotrowska, Natalia Glatzel-Plucinska, Katarzyna Ratajczak, Patrycja Sputa-Grzegrzolka, Adam Rzechonek, Bozena Werynska, Marzena Podhorska-Okolow, Piotr Dziegiel
Summary: The study aimed to evaluate the localization and intensity of tesmin, MCM5 and MCM7 protein expression in NSCLC, and their association with clinicopathological data of patients. Positive associations were found between the expression of tesmin, MCM5 and MCM7 in NSCLC, indicating a possible role of tesmin in the proliferation of NSCLC cancer cells.
Article
Oncology
Wenwen Guo, Tianyun Qiao, Tian Li
Summary: Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer, and although chemotherapy can shrink tumors, most patients experience recurrence and metastasis within a few months. Targeting cancer stem cells (CSCs) has been successful in certain malignancies, and immunotherapeutic approaches show effectiveness in targeting CSCs, with potential for combination with chemotherapy. Understanding the interaction between CSCs and the immune system is crucial for advancing new immunotherapies targeting CSCs and combination therapies with standard drugs such as chemotherapy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
David W. W. Shia, WooSuk Choi, Preethi Vijayaraj, Valarie Vuong, Jenna M. M. Sandlin, Michelle M. M. Lu, Adam Aziz, Caliope Marin, Cody J. J. Aros, Chandani Sen, Abdo Durra, Andrew J. J. Lund, Arunima Purkayastha, Tammy M. M. Rickabaugh, Thomas G. G. Graeber, Brigitte N. N. Gomperts
Summary: This study identified PEA3 transcription factors as key mediators of relapse progression in small cell lung cancer (SCLC) and identified a clinically actionable small molecule candidate for delaying relapse of SCLC.
Article
Biochemistry & Molecular Biology
Yanhui Deng, Junjie Shi, Yi Ran, Andy Peng Xiang, Chengguo Yao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Xin Feng, Kai Xia, Qiong Ke, Rongda Deng, Jintao Zhuang, Zi Wan, Peng Luo, Fulin Wang, Zhijun Zang, Xiangzhou Sun, Andy Peng Xiang, Xiang'an Tu, Yong Gao, Chunhua Deng
Summary: A study demonstrated the successful establishment of an efficient differentiation system to obtain functional Leydig-like cells from human stem Leydig cells. These cells were able to partially restore testosterone production in vivo and ameliorate symptoms of testosterone deficiency, showing promising potential for clinical applications.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Immunology
Shuwei Zheng, Ke Huang, Wenjie Xia, Jiahao Shi, Qiuli Liu, Xiaoran Zhang, Gang Li, Jieying Chen, Tao Wang, Xiaoyong Chen, Andy Peng Xiang
Summary: Activated T cells can rapidly adhere to MSCs, leading to a significant reduction in proinflammatory cytokine expression. MSCs rapidly suppress TCR signaling and downstream pathways in a cell-cell contact-dependent manner, partially through the ICAM-1/CD43 adhesion interaction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yongcheng Wei, Xiaoyong Chen, Huanxi Zhang, Qun Su, Yanwen Peng, Qian Fu, Jun Li, Yifang Gao, Xirui Li, Shicong Yang, Qianyu Ye, Huiting Huang, Ronghai Deng, Gang Li, Bowen Xu, Chenglin Wu, Jiali Wang, Xiaoran Zhang, Xiaojun Su, Longshan Liu, Andy Peng Xiang, Changxi Wang
Summary: BM-MSCs are tolerable for kidney allograft recipients with cABMR, and combined with immunosuppressive drugs can delay allograft function deterioration by reducing DSA levels and DSA-induced injury. The immunomodulatory effect of MSCs on peripheral B and T cell subsets may be the underlying mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Lei Wang, Jiani Cao, Yaojin Peng, Boqiang Fu, Zibing Jin, Yuntao Hu, Wei Wu, Andy Peng Xiang, Shijun Hu, Junying Yu, Yu Zhang, Jun Wei, Yong Zhang, Qiyuan Li, Jiaxi Zhou, Peijun Zhai, Huanxin Zhu, Lingmin Liang, Aijin Ma, Glyn Stacey, Tongbiao Zhao, Jie Hao
Summary: The guidelines for human retinal pigment epithelial cells in China were jointly drafted by experts from the Chinese Society for Stem Cell Research, aiming to improve quality control and accelerate international standardization.
CELL PROLIFERATION
(2022)
Article
Respiratory System
Jiancheng Wang, Xiaofan Lai, Senyu Yao, Hainan Chen, Jianye Cai, Yulong Luo, Yi Wang, Yuan Qiu, Yinong Huang, Xiaoyue Wei, Boyan Wang, Qiying Lu, Yuanjun Guan, Tao Wang, Shiyue Li, Andy Peng Xiang
Summary: This study found that nestin is upregulated in a pulmonary fibrosis model and IPF patients, primarily localized in myofibroblasts. Knockdown of nestin inhibited TGF-beta signaling and alleviated pulmonary fibrosis. These findings provide new insights into the treatment of pulmonary fibrosis.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Jialing Liu, Xingqiang Lai, Yingying Bao, Wenfeng Xie, Zhishan Li, Jieying Chen, Gang Li, Tao Wang, Weijun Huang, Yuanchen Ma, Jiahao Shi, Erming Zhao, Andy Peng Xiang, Qiuli Liu, Xiaoyong Chen
Summary: Intraperitoneally delivered mesenchymal stem cells (MSCs) secrete THBS1 to boost IL-10(+)Bregs and control the progression and recurrence of inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Huang, Ronghai Deng, Weiqiang Li, Meihua Jiang, Andy Peng Xiang, Xiaoran Zhang
Summary: This study found that Nes-GFP(+) cells derived from the spleen have stronger immunomodulatory ability and therapeutic potential compared to those derived from bone marrow. These spleen-derived cells also demonstrated the ability to establish ectopic lymphoid-like structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jieying Chen, Jing Huang, Jiahao Shi, Minrong Li, Erming Zhao, Gang Li, Xiaoyong Chen, Tao Wang, Qiaojia Li, Weiqiang Li, Jianping Ma, Wenzhe Mao, Rui Fang, Jiang Hao, Weijun Huang, Andy Peng Xiang, Xiaoran Zhang
Summary: This study demonstrated that MSCs derived from murine Peyer's patches possess enhanced immunoregulatory ability compared to bone marrow-derived MSCs. They were able to suppress T cell proliferation and inflammatory cytokine production. Furthermore, these Peyer's patch-derived MSCs exhibited greater therapeutic efficacy in murine IBD models. IL-22, which was highly expressed in these MSCs, played a significant role in alleviating the severity of intestinal inflammation.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Huanyao Liu, Shanshan Huang, Weijia Wang, Huiyan Wang, Weijun Huang, Zhichen Zhai, Ding Wang, Yubao Fan, Jiaqi Sun, Dairui Li, Weicheng Chiu, Xingqiang Lai, Jixiao Zeng, Qiong Ke, Tao Wang, Andy Peng Xiang, Yong Yuan, Xinchun Zhang, Weiqiang Li
Summary: This study explores the potential underlying causes of craniofacial dysmorphology in individuals with Down syndrome (DS) and identifies potential therapeutic targets. The researchers find that migration defects in neural crest cells may contribute to craniofacial anomalies in DS, and they discover that the triplication of the CXADR gene in DS cells is partially responsible for these migration defects.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Kai Xia, Fulin Wang, Xingqiang Lai, Lin Dong, Peng Luo, Suyuan Zhang, Cuifeng Yang, Hong Chen, Yuanchen Ma, Weijun Huang, Wangsheng Ou, Yuyan Li, Xin Feng, Bin Yang, Congyuan Liu, Zhenmin Lei, Xiang'an Tu, Qiong Ke, Frank Fuxiang Mao, Chunhua Deng, Andy Peng Xiang
Summary: The study demonstrates that AAV-mediated gene therapy may represent a promising therapeutic approach for patients with Leydig cell failure (LCF) as it can restore testosterone production and fertility effectively.
CELL REPORTS MEDICINE
(2022)
Article
Cell Biology
Yu-Kai Wang, Lin Feng, Ai-Jin Ma, Jie Hao, Ying Zhang, Yue-Jun Chen, Zhi-Guo Chen, Jun-Ying Yu, Yan Liu, Chang-Mei Liu, Yu Zhang, Chang-Lin Wang, Zhao-Qian Teng, Jia-Xi Zhou, Tian-Qing Li, Liu Wang, Bo-Qiang Fu, Yu Vincent Fu, Li-Jun Zhu, Ling-Min Liang, Jia-Ni Cao, Lei Wang, Qi Zhou, Andy Peng Xiang, Bao-Yang Hu, Tong-Biao Zhao
Summary: The "Guideline for Human Midbrain Dopaminergic Progenitors" is the first guideline in China specifically addressing human midbrain dopaminergic progenitors. It provides detailed technical requirements, test methods, and instructions for usage, which are crucial for quality control in this field. The publication of this guideline is expected to promote the establishment and implementation of proper protocols, and encourage international standardization in the clinical development and therapeutic applications of human midbrain dopaminergic progenitors.
CELL PROLIFERATION
(2023)
Editorial Material
Cell Biology
Yu-Kai Wang, Juan Yu, Ting-Ting Zhang, Ai-Jin Ma, Jie Hao, Yue-Jun Chen, Chang-Mei Liu, Yan Liu, Chang-Lin Wang, Pei-Jun Zhai, Andy Peng Xiang, Tian-Qing Li, Tie-Shan Tang, Hong Chen, Xin-Jie Bao, Yan-Lin Wang, Wen-Yan He, Jing Fan, Zhao-Qian Teng, Liu Wang, Jia-Xi Zhou, Bo-Qiang Fu, Yu Vincent Fu, Lin Feng, Jia-Ni Cao, Ling-Min Liang, Lei Wang, Qi Zhou, Yu Zhang, Bao-Yang Hu, Tong-Biao Zhao
Summary: The "Guideline for Human Neural Stem Cells" jointly drafted by Chinese experts is the first of its kind in China. It provides technical requirements and quality control standards for hNSCs. The publication of this guideline aims to facilitate institutional establishment, acceptance, and implementation of proper protocols, as well as to accelerate the international standardization of hNSCs for clinical development and therapeutic applications.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Senyu Yao, Mao Pang, Yanheng Wang, Xiaokang Wang, Yaobang Lin, Yanyan Lv, Ziqi Xie, Jianfeng Hou, Cong Du, Yuan Qiu, Yuanjun Guan, Bin Liu, Jiancheng Wang, Andy Peng Xiang, Limin Rong
Summary: This study demonstrates that mitochondrial quality control plays a crucial role in regulating neuronal ferroptosis and mesenchymal stem cells can attenuate ferroptosis through mitochondrial transfer and fusion. The findings provide insights into the molecular mechanism underlying neuronal ferroptosis and suggest a potential clinical translation strategy using stem cell-mediated mitochondrial therapy.
Article
Biochemistry & Molecular Biology
Chuqian Liang, Qiong Ke, Zunpeng Liu, Jie Ren, Weiqi Zhang, Jianli Hu, Zehua Wang, Hong Chen, Kai Xia, Xingqiang Lai, Qiaoran Wang, Kuan Yang, Wei Li, Zeming Wu, Chao Wang, Haoteng Yan, Xiaoyu Jiang, Zhejun Ji, Miyang Ma, Xiao Long, Si Wang, Huating Wang, Hao Sun, Juan Carlos Izpisua Belmonte, Jing Qu, Andy Peng Xiang, Guang-Hui Liu
Summary: This study reveals a noncanonical role of BMAL1 in stabilizing heterochromatin to inactivate LINE1, thereby driving aging in primate cells.
NUCLEIC ACIDS RESEARCH
(2022)