Multiscale engineering of immune cells and lymphoid organs

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome–mediated metabolic syndrome

(2019) Matthew J. Mosquera et al.   Science Advances

An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

(2019) Nisarg J. Shah et al.   NATURE BIOTECHNOLOGY

Current approaches in biomaterial-based hematopoietic stem cell niches

(2018) Alvin Bacero Bello et al.   Acta Biomaterialia

Mechanobiological Mimicry of Helper T Lymphocytes to Evaluate Cell-Biomaterials Crosstalk

(2018) Mohammad Mahdi Hasani-Sadrabadi et al.   ADVANCED MATERIALS

Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production

(2018) Lorenzo Tozzi et al.   BIOMATERIALS

A synthetic stroma-free germinal center niche for efficient generation of humoral immunity ex vivo

(2018) Kyung-Ho Roh et al.   BIOMATERIALS

Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells

(2018) Alberto Purwada et al.   BIOMATERIALS

Adventitial tertiary lymphoid organ classification in human atherosclerosis

(2018) Mohammadreza Akhavanpoor et al.   CARDIOVASCULAR PATHOLOGY

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer

(2018) Alessandra Nerviani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

(2018) Alexander S Cheung et al.   NATURE BIOTECHNOLOGY

Designing cell function: assembly of synthetic gene circuits for cell biology applications

(2018) Mingqi Xie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vitro biomimetic engineering of a human hematopoietic niche with functional properties

(2018) Paul E. Bourgine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

(2018) Christian Chabannon et al.   Science Translational Medicine

Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma

(2018) Maaike V.J. Braham et al.   TISSUE ENGINEERING PART C-METHODS

The Increasingly Human and Profitable Monoclonal Antibody Market

(2018) António L. Grilo et al.   TRENDS IN BIOTECHNOLOGY

Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis

(2018) S. Esmaeil Dorraji et al.   Scientific Reports

Protein-Scaffold Directed Nanoscale Assembly of T Cell Ligands: Artificial Antigen Presentation with Defined Valency, Density, and Ratio

(2018) Mason R. Smith et al.   ACS Synthetic Biology

How Biophysical Forces Regulate Human B Cell Lymphomas

(2018) F. Apoorva et al.   Cell Reports

Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model

(2018) Maaike V. J. Braham et al.   OncoImmunology

Extracellular matrix-based materials for regenerative medicine

(2018) George S. Hussey et al.   Nature Reviews Materials

Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: Enhancing production and purity

(2018) Jennifer H. Shepherd et al.   BIOMATERIALS

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes

(2018) Stine L. Figenschau et al.   Scientific Reports

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

(2018) Eric Shifrut et al.   CELL

Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection

(2018) Wenjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

Award Winner in the Young Investigator Category, 2017 Society for Biomaterials Annual Meeting and Exposition, Minneapolis, MN, April 05-08, 2017: Lymph node stiffness-mimicking hydrogels regulate human B-cell lymphoma growth and cell surface receptor expr

(2017) F.N.U. Apoorva et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

(2017) Christopher S Seet et al.   NATURE METHODS

Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1

(2017) Shreya Shukla et al.   NATURE METHODS

Chimeric antigen receptor T-cell therapy — assessment and management of toxicities

(2017) Sattva S. Neelapu et al.   Nature Reviews Clinical Oncology

In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism

(2017) Yu-Ru Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

(2017) Wendy Béguelin et al.   Nature Communications

3D models of the hematopoietic stem cell niche under steady-state and active conditions

(2017) Lisa Rödling et al.   Scientific Reports

Pneumocystis -Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity

(2017) Taylor Eddens et al.   Cell Reports

Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation

(2017) Alberto Purwada et al.   ACS Biomaterials-Science & Engineering

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression

(2017) María de la Luz García-Hernández et al.   Frontiers in Immunology

Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation

(2017) Alberto Purwada et al.   ACS Biomaterials Science & Engineering

Marrow-inspired matrix cues rapidly affect early fate decisions of hematopoietic stem and progenitor cells

(2017) Ji Sun Choi et al.   Science Advances

RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury

(2017) Andrea J. Mothe et al.   Scientific Reports

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-termex vivoculture of HSC/HPCs

(2016) Xiaobing Huang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites

(2016) Mónica S. Ventura Ferreira et al.   Journal of Hematology & Oncology

Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial

(2016) Harold L Atkins et al.   LANCET

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production

(2016) Alberto Purwada et al.   Nature Protocols

Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells

(2016) Dana Vu Van et al.   Nature Communications

Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together

(2016) Gareth W. Jones et al.   Frontiers in Immunology

Gel-Trapped Lymphorganogenic Chemokines Trigger Artificial Tertiary Lymphoid Organs and Mount Adaptive Immune Responses In Vivo

(2016) Yuka Kobayashi et al.   Frontiers in Immunology

Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

(2016) Justyna Ogonek et al.   Frontiers in Immunology

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy

(2015) Karlo Perica et al.   ACS Nano

Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells

(2015) Ye F. Tian et al.   BIOMATERIALS

Ex vivo engineered immune organoids for controlled germinal center reactions

(2015) Alberto Purwada et al.   BIOMATERIALS

Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies

(2015) C. A. Di Buduo et al.   BLOOD

Bioengineering mini functional thymic units with EAK16-II/EAKIIH6 self-assembling hydrogel

(2015) Asako Tajima et al.   CLINICAL IMMUNOLOGY

Synthetic biology approaches to engineer T cells

(2015) Chia-Yung Wu et al.   CURRENT OPINION IN IMMUNOLOGY

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts

(2015) Yong Fan et al.   MOLECULAR THERAPY

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes

(2015) M. Furkan Burak et al.   Science Translational Medicine

Long-Term Results in Recipients of Combined HLA-Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression

(2014) T. Kawai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Integrin  v 3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

(2014) F. Cayrol et al.   BLOOD

Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model

(2014) M. R. Reagan et al.   BLOOD

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

The promise and challenge of high-throughput sequencing of the antibody repertoire

(2014) George Georgiou et al.   NATURE BIOTECHNOLOGY

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

A carbon nanotube–polymer composite for T-cell therapy

(2014) Tarek R. Fadel et al.   Nature Nanotechnology

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD28 and CD3 have complementary roles in T-cell traction forces

(2014) Keenan T. Bashour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

Highly elastomeric poly(glycerol sebacate)-co-poly(ethylene glycol) amphiphilic block copolymers

(2013) Alpesh Patel et al.   BIOMATERIALS

Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells

(2013) Annamarija Raic et al.   BIOMATERIALS

MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

(2013) Jan C. Dudda et al.   IMMUNITY

Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity

(2013) Cor HJ Lamers et al.   MOLECULAR THERAPY

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Adhesion strength–based, label-free isolation of human pluripotent stem cells

(2013) Ankur Singh et al.   NATURE METHODS

Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements

(2013) Saloni Mittal et al.   PLoS One

How vinculin regulates force transmission

(2013) D. W. Dumbauld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Based Therapeutics: The Next Pillar of Medicine

(2013) M. A. Fischbach et al.   Science Translational Medicine

Microfluidic Generation of Gradient Hydrogels to Modulate Hematopoietic Stem Cell Culture Environment

(2013) Bhushan P. Mahadik et al.   Advanced Healthcare Materials

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support

(2012) Mónica S. Ventura Ferreira et al.   BIOMATERIALS

Responsive culture platform to examine the influence of microenvironmental geometry on cell function in 3D

(2012) April M. Kloxin et al.   Integrative Biology

Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

(2012) S. R. Coyer et al.   JOURNAL OF CELL SCIENCE

The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach

(2012) Jan J. Cornelissen et al.   Nature Reviews Clinical Oncology

Targeting IL-7 reverses type 1 diabetes

(2012) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

(2012) C. Penaranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Tertiary lymphoid organs in infection and autoimmunity

(2012) Katrijn Neyt et al.   TRENDS IN IMMUNOLOGY

A Theory of Germinal Center B Cell Selection, Division, and Exit

(2012) Michael Meyer-Hermann et al.   Cell Reports

Carbon Nanotube Reinforced Hybrid Microgels as Scaffold Materials for Cell Encapsulation

(2011) Su Ryon Shin et al.   ACS Nano

Protein Tethering into Multiscale Geometries by Covalent Subtractive Printing

(2011) Sean R. Coyer et al.   ADVANCED MATERIALS

Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds

(2011) Teresa Mortera-Blanco et al.   BIOMATERIALS

3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche

(2011) Isabelle Leisten et al.   BIOMATERIALS

Mechanisms of thymus organogenesis and morphogenesis

(2011) J. Gordon et al.   DEVELOPMENT

An injectable synthetic immune-priming center mediates efficient T-cell class switching and T-helper 1 response against B cell lymphoma

(2011) Ankur Singh et al.   JOURNAL OF CONTROLLED RELEASE

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

(2011) Cole A. DeForest et al.   Nature Chemistry

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Nanowired three-dimensional cardiac patches

(2011) Tal Dvir et al.   Nature Nanotechnology

Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal

(2011) J. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

(2011) Takuya Nojima et al.   Nature Communications

Interfacing Carbon Nanotubes with Living Mammalian Cells and Cytotoxicity Issues

(2010) Hui-Fang Cui et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cytokine crosstalk for thymic medulla formation

(2010) Takeshi Nitta et al.   CURRENT OPINION IN IMMUNOLOGY

Three-dimensional culture of mouse bone marrow cells within a porous polymer scaffold: effects of oxygen concentration and stromal layer on expansion of haematopoietic progenitor cells

(2010) Hirotoshi Miyoshi et al.   Journal of Tissue Engineering and Regenerative Medicine

Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation

(2010) Yixin Li et al.   Journal of Translational Medicine

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Infection-mimicking materials to program dendritic cells in situ

(2009) Omar A. Ali et al.   NATURE MATERIALS

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry

(2008) Joan E. Nichols et al.   BIOMATERIALS

The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells

(2008) R. Zappasodi et al.   HAEMATOLOGICA

A Comprehensive Platform for Ex Vivo T-cell Expansion Based on Biodegradable Polymeric Artificial Antigen-presenting Cells

(2008) Erin R Steenblock et al.   MOLECULAR THERAPY

Enhanced Cellular Activation with Single Walled Carbon Nanotube Bundles Presenting Antibody Stimuli

(2008) Tarek R. Fadel et al.   NANO LETTERS

Micropatterning of costimulatory ligands enhances CD4+ T cell function

(2008) K. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA