The promise and challenge of high-throughput sequencing of the antibody repertoire
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Title
The promise and challenge of high-throughput sequencing of the antibody repertoire
Authors
Keywords
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Journal
NATURE BIOTECHNOLOGY
Volume 32, Issue 2, Pages 158-168
Publisher
Springer Nature
Online
2014-01-20
DOI
10.1038/nbt.2782
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Note: Only part of the references are listed.- IgH gene rearrangements as plasma biomarkers in Non-Hodgkin's Lymphoma patients
- (2015) Jian He et al. Oncotarget
- Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing
- (2015) Renee C. Tschumper et al. Oncotarget
- Unifying immunology with informatics and multiscale biology
- (2014) Brian A Kidd et al. NATURE IMMUNOLOGY
- Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity, and Joining Genes and Characterization of Allelic and Copy-Number Variation
- (2013) Corey T. Watson et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Broadly Neutralizing Antiviral Antibodies
- (2013) Davide Corti et al. Annual Review of Immunology
- Reshaping Antibody Diversity
- (2013) Feng Wang et al. CELL
- Convergent Antibody Signatures in Human Dengue
- (2013) Poornima Parameswaran et al. Cell Host & Microbe
- Human lymphocyte repertoires in ageing
- (2013) Scott D Boyd et al. CURRENT OPINION IN IMMUNOLOGY
- Intrinsic bias and public rearrangements in the human immunoglobulin Vλ light chain repertoire
- (2013) K H Hoi et al. GENES AND IMMUNITY
- Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis
- (2013) Lucas J. Maillette de Buy Wenniger et al. HEPATOLOGY
- Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
- (2013) Tongqing Zhou et al. IMMUNITY
- Atypical and classical memory B cells producePlasmodium falciparumneutralizing antibodies
- (2013) Matthias F. Muellenbeck et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
- (2013) Khaled Amara et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Restricted DH Gene Reading Frame Usage in the Expressed Human Antibody Repertoire Is Selected Based upon its Amino Acid Content
- (2013) J. Benichou et al. JOURNAL OF IMMUNOLOGY
- Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential
- (2013) Ciara M. Mahon et al. JOURNAL OF MOLECULAR BIOLOGY
- Clues to pathogenesis of Waldenström macroglobulinemia and immunoglobulin M monoclonal gammopathy of undetermined significance provided by analysis of immunoglobulin heavy chain gene rearrangement and clustering of B-cell receptors
- (2013) Marzia Varettoni et al. LEUKEMIA & LYMPHOMA
- Deep sequencing of phage display libraries to support antibody discovery
- (2013) Ulla Ravn et al. METHODS
- Evolutionary implications of a third lymphocyte lineage in lampreys
- (2013) Masayuki Hirano et al. NATURE
- Microbial colonization influences early B-lineage development in the gut lamina propria
- (2013) Duane R. Wesemann et al. NATURE
- Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
- (2013) Hua-Xin Liao et al. NATURE
- Prize-based contests can provide solutions to computational biology problems
- (2013) Karim R Lakhani et al. NATURE BIOTECHNOLOGY
- High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire
- (2013) Brandon J DeKosky et al. NATURE BIOTECHNOLOGY
- Correlation of Gene Expression and Genome Mutation in Single B-Cells
- (2013) Joshua A. Weinstein et al. PLoS One
- Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response
- (2013) Y. Wine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic measurement of memory B-cell recall using antibody repertoire sequencing
- (2013) C. Vollmers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains
- (2013) J. Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts
- (2013) J. Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing
- (2013) S. Mohr et al. RNA
- Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination
- (2013) N. Jiang et al. Science Translational Medicine
- Teleost Fish Mount Complex Clonal IgM and IgT Responses in Spleen upon Systemic Viral Infection
- (2013) Rosario Castro et al. PLoS Pathogens
- Somatic populations of PGT135–137 HIV-1-neutralizing antibodies identified by 454 pyrosequencing and bioinformatic
- (2013) Jiang Zhu Frontiers in Microbiology
- Germinal Centers
- (2012) Gabriel D. Victora et al. Annual Review of Immunology
- Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
- (2012) C. Gawad et al. BLOOD
- Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia
- (2012) M. Faham et al. BLOOD
- Application of circular consensus sequencing and network analysis to characterize the bovine IgG repertoire
- (2012) Peter A Larsen et al. BMC IMMUNOLOGY
- A Blueprint for HIV Vaccine Discovery
- (2012) Dennis R. Burton et al. Cell Host & Microbe
- Wrestling with the repertoire: The promise and perils of next generation sequencing for antigen receptors
- (2012) Paul D. Baum et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Next generation sequencing for TCR repertoire profiling: Platform-specific features and correction algorithms
- (2012) Dmitry A. Bolotin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals
- (2012) B S Briney et al. GENES AND IMMUNITY
- Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity
- (2012) B S Briney et al. GENES AND IMMUNITY
- Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies
- (2012) Peter D. Kwong et al. IMMUNITY
- Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire
- (2012) Bryan S. Briney et al. IMMUNOLOGY
- Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution
- (2012) Ramit Mehr et al. IMMUNOLOGY LETTERS
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- (2012) H.-Christian von Büdingen et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2012) Cornelia Lindner et al. JOURNAL OF EXPERIMENTAL MEDICINE
- In Vivo VL-Targeted Microbial Superantigen Induced Global Shifts in the B Cell Repertoire
- (2012) C. Gronwall et al. JOURNAL OF IMMUNOLOGY
- Shaping of Human Germline IgH Repertoires Revealed by Deep Sequencing
- (2012) K. Larimore et al. JOURNAL OF IMMUNOLOGY
- Skewed Primary Ig Repertoire and V-J Joining in C57BL/6 Mice: Implications for Recombination Accessibility and Receptor Editing
- (2012) M. Aoki-Ota et al. JOURNAL OF IMMUNOLOGY
- B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients
- (2012) Nathan Schoettler et al. MOLECULAR IMMUNOLOGY
- Proteomics-directed cloning of circulating antiviral human monoclonal antibodies
- (2012) Shuji Sato et al. NATURE BIOTECHNOLOGY
- A proteomics approach for the identification and cloning of monoclonal antibodies from serum
- (2012) Wan Cheung Cheung et al. NATURE BIOTECHNOLOGY
- B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
- (2012) Barton F Haynes et al. NATURE BIOTECHNOLOGY
- Performance comparison of benchtop high-throughput sequencing platforms
- (2012) Nicholas J Loman et al. NATURE BIOTECHNOLOGY
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- New tools for classification and monitoring of autoimmune diseases
- (2012) Holden T. Maecker et al. Nature Reviews Rheumatology
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- (2012) Rajneesh Srivastava et al. NEW ENGLAND JOURNAL OF MEDICINE
- Quantifying selection in high-throughput Immunoglobulin sequencing data sets
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- Antibody Repertoires in Humanized NOD-scid-IL2Rγnull Mice and Human B Cells Reveals Human-Like Diversification and Tolerance Checkpoints in the Mouse
- (2012) Gregory C. Ippolito et al. PLoS One
- Onset of Immune Senescence Defined by Unbiased Pyrosequencing of Human Immunoglobulin mRNA Repertoires
- (2012) Florian Rubelt et al. PLoS One
- Construction of a rationally designed antibody platform for sequencing-assisted selection
- (2012) H. B. Larman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of ultra-rare mutations by next-generation sequencing
- (2012) M. W. Schmitt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes
- (2012) K. Shiroguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing
- (2012) Ponraj Prabakaran et al. Frontiers in Microbiology
- Automated cleaning and pre-processing of immunoglobulin gene sequences from high-throughput sequencing
- (2012) Miri Michaeli et al. Frontiers in Immunology
- Advances in Human B Cell Phenotypic Profiling
- (2012) Denise A. Kaminski et al. Frontiers in Immunology
- Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages
- (2011) Alexander Ademokun et al. AGING CELL
- Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire
- (2011) Phuong Nguyen et al. BMC GENOMICS
- Addressing challenges in the production and analysis of illumina sequencing data
- (2011) Martin Kircher et al. BMC GENOMICS
- Genomic screening by 454 pyrosequencing identifies a new human IGHV gene and sixteen other new IGHV allelic variants
- (2011) Yan Wang et al. IMMUNOGENETICS
- Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells
- (2011) Katherine Jean Louise Jackson et al. IMMUNOGENETICS
- Rep-Seq: uncovering the immunological repertoire through next-generation sequencing
- (2011) Jennifer Benichou et al. IMMUNOLOGY
- The Inference of Phased Haplotypes for the Immunoglobulin H Chain V Region Gene Loci by Analysis of VDJ Gene Rearrangements
- (2011) M. J. Kidd et al. JOURNAL OF IMMUNOLOGY
- Epitope-Specific Human Influenza Antibody Repertoires Diversify by B Cell Intraclonal Sequence Divergence and Interclonal Convergence
- (2011) J. C. Krause et al. JOURNAL OF IMMUNOLOGY
- Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids
- (2011) L. Wu et al. JOURNAL OF IMMUNOLOGY
- Sequencing antibody repertoires
- (2011) Nicolas Fischer mAbs
- Beyond natural antibodies: the power of in vitro display technologies
- (2011) Andrew R M Bradbury et al. NATURE BIOTECHNOLOGY
- Antibody Vh Repertoire Differences between Resolving and Chronically Evolving Hepatitis C Virus Infections
- (2011) Vito Racanelli et al. PLoS One
- High-Resolution Description of Antibody Heavy-Chain Repertoires in Humans
- (2011) Ramy Arnaout et al. PLoS One
- Counting individual DNA molecules by the stochastic attachment of diverse labels
- (2011) G. K. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
- (2011) J. Glanville et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Determinism and stochasticity during maturation of the zebrafish antibody repertoire
- (2011) N. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment
- (2011) A. C. Logan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection and quantification of rare mutations with massively parallel sequencing
- (2011) I. Kinde et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells
- (2011) J. F. Scheid et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IgE Sequences in Individuals Living in an Area of Endemic Parasitism Show Little Mutational Evidence of Antigen Selection
- (2011) Y. Wang et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
- (2011) X. Wu et al. SCIENCE
- A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins
- (2011) D. Corti et al. SCIENCE
- Targeting TLRs Expands the Antibody Repertoire in Response to a Malaria Vaccine
- (2011) S. R. Wiley et al. Science Translational Medicine
- High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations
- (2010) Y.-C. Wu et al. BLOOD
- The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity
- (2010) Martina Beltramello et al. Cell Host & Microbe
- Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements
- (2010) S. D. Boyd et al. JOURNAL OF IMMUNOLOGY
- Antigen Receptor Allelic Exclusion: An Update and Reappraisal
- (2010) B. L. Brady et al. JOURNAL OF IMMUNOLOGY
- Regulation of the B Cell Receptor Repertoire and Self-Reactivity by BAFF
- (2010) M. Ota et al. JOURNAL OF IMMUNOLOGY
- Model for comparative analysis of antigen receptor repertoires
- (2010) Grzegorz A. Rempala et al. JOURNAL OF THEORETICAL BIOLOGY
- Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells
- (2010) Sai T Reddy et al. NATURE BIOTECHNOLOGY
- By-passing in vitro screening—next generation sequencing technologies applied to antibody display and in silico candidate selection
- (2010) U. Ravn et al. NUCLEIC ACIDS RESEARCH
- Maximum entropy models for antibody diversity
- (2010) T. Mora et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
- (2009) Johannes F. Scheid et al. NATURE
- Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
- (2009) J. Glanville et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-Throughput Sequencing of the Zebrafish Antibody Repertoire
- (2009) J. A. Weinstein et al. SCIENCE
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing
- (2009) S. D. Boyd et al. Science Translational Medicine
- B-cell tolerance checkpoints in health and autoimmunity
- (2008) Eric Meffre et al. CURRENT OPINION IN IMMUNOLOGY
- Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors
- (2008) Xiaocong Yu et al. NATURE
- Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
- (2008) Jens Wrammert et al. NATURE
- Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
- (2008) P. J. Campbell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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