Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation

(2019) Qi Li et al.   XENOTRANSPLANTATION

Infectious disease risks in xenotransplantation

(2018) Jay A. Fishman   AMERICAN JOURNAL OF TRANSPLANTATION

Swine Leukocyte Antigen Class II Is a Xenoantigen

(2018) Joseph M. Ladowski et al.   TRANSPLANTATION

Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells

(2018) Zhongqiang Zhang et al.   TRANSPLANTATION

Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates

(2018) Liaoran Wang et al.   TRANSPLANTATION

Pigs expressing the human inhibitory ligand PD-L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties

(2018) Anna Buermann et al.   XENOTRANSPLANTATION

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

(2018) Hayato Iwase et al.   COMPARATIVE MEDICINE

Elimination of donor CD47 protects against vascularized allograft rejection in mice

(2018) Mo Chen et al.   XENOTRANSPLANTATION

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?

(2018) Hayato Iwase et al.   XENOTRANSPLANTATION

Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs

(2018) Adeline N. Boettcher et al.   XENOTRANSPLANTATION

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Complement as a regulator of adaptive immunity

(2017) Justin Killick et al.   Seminars in Immunopathology

Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs

(2017) Gregory R. Martens et al.   TRANSPLANTATION

Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47

(2017) Aseda A. Tena et al.   TRANSPLANTATION

Therapeutic regulation of systemic inflammation in xenograft recipients

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

The potentiating effect of hTFPI in the presence of hCD47 reduces the cytotoxicity of human macrophages

(2017) Sung Han Jung et al.   XENOTRANSPLANTATION

Synthetic liver function is detectable in transgenic porcine livers perfused with human blood

(2017) Arielle Cimeno et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse

(2017) Kaila M. Bennett et al.   Frontiers in Microbiology

Complement Evasion Strategies of Viruses: An Overview

(2017) Palak Agrawal et al.   Frontiers in Microbiology

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans

(2017) Bingsi Gao et al.   PLoS One

Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

(2016) Kristina N. Ekdahl et al.   IMMUNOLOGICAL REVIEWS

Beneficial effects of the transgenic expression of human sTNF-αR-Fc and HO-1 on pig-to-mouse islet xenograft survival

(2016) Ji-Jing Yan et al.   TRANSPLANT IMMUNOLOGY

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs

(2015) H. Iwase et al.   TRANSPLANT IMMUNOLOGY

Further evidence for sustained systemic inflammation in xenograft recipients (SIXR)

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Transgenic expression of human CD46: does it reduce the primate T-cell response to pig endothelial cells?

(2015) Mohamed B Ezzelarab et al.   XENOTRANSPLANTATION

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

(2015) Mohamed B. Ezzelarab et al.   International Journal of Surgery

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

Systemic inflammation in xenograft recipients precedes activation of coagulation

(2014) Mohamed B. Ezzelarab et al.   XENOTRANSPLANTATION

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates

(2014) Zheng-Yu Wang et al.   XENOTRANSPLANTATION

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status

(2013) Hidetaka Hara et al.   IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

The suppression of inflammatory macrophage-mediated cytotoxicity and proinflammatory cytokine production by transgenic expression of HLA-E

(2013) Akira Maeda et al.   TRANSPLANT IMMUNOLOGY

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition

(2013) Hayato Iwase et al.   XENOTRANSPLANTATION

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

(2013) Steven Johnson et al.   Cell Reports

Innate cellular immunity and xenotransplantation

(2012) Hui Wang et al.   Current Opinion in Organ Transplantation

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

(2012) N. Klymiuk et al.   DIABETES

Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

(2012) Christopher G.A. McGregor et al.   TRANSPLANTATION

Clinical lung xenotransplantation - what donor genetic modifications may be necessary?

(2012) David K. C. Cooper et al.   XENOTRANSPLANTATION

The effect of Gal expression on pig cells on the human T-cell xenoresponse

(2012) Tyler Wilhite et al.   XENOTRANSPLANTATION

CD47: a new player in phagocytosis and xenograft rejection

(2011) Nalu Navarro-Alvarez et al.   Cellular & Molecular Immunology

Novel roles of complement in T effector cell regulation

(2011) Peter S. Heeger et al.   IMMUNOBIOLOGY

Pathologic Characteristics of Transplanted Kidney Xenografts

(2011) A. Shimizu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

IN VIVO AND IN VITRO EFFECTS OF THE ANTICOAGULANT, THROMBOMODULIN, ON THE INFLAMMATORY RESPONSE IN RODENT MODELS

(2010) Satoshi Hagiwara et al.   SHOCK

Combined Gene Therapy with Hypoxia-Inducible Factor-1α and Heme Oxygenase-1 for Therapeutic Angiogenesis

(2010) Suk Ho Bhang et al.   TISSUE ENGINEERING PART A

Role of heme oxygenase-1 in transplantation

(2010) Robert Öllinger et al.   TRANSPLANT INTERNATIONAL

Downregulation of cytolytic activity of human effector cells by transgenic expression of human PD-ligand-1 on porcine target cells

(2010) Annegret Plege et al.   TRANSPLANT INTERNATIONAL

Review Article: CD47 in xenograft rejection and tolerance induction

(2010) Yong-Guang Yang   XENOTRANSPLANTATION

Complement regulation in the GalT KO era

(2010) Shuji Miyagawa et al.   XENOTRANSPLANTATION

Heme oxygenase-1: from biology to therapeutic potential

(2009) Miguel P. Soares et al.   TRENDS IN MOLECULAR MEDICINE

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

(2009) Jagdeece Ramsoondar et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Thrombotic Microangiopathy Associated with Humoral Rejection of Cardiac Xenografts from α1,3-Galactosyltransferase Gene-Knockout Pigs in Baboons

(2008) Akira Shimizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities

(2008) Agnieszka Loboda et al.   ANTIOXIDANTS & REDOX SIGNALING

In vitroinvestigation of pig cells for resistance to human antibody-mediated rejection

(2008) Hidetaka Hara et al.   TRANSPLANT INTERNATIONAL

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs

(2008) Britta Dieckhoff et al.   XENOTRANSPLANTATION