Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs

Creating effective biocontainment facilities and maintenance protocols for raising specific pathogen-free, severe combined immunodeficient (SCID) pigs

(2018) Ellis J Powell et al.   LABORATORY ANIMALS

Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies

(2017) E C Pietsch et al.   Blood Cancer Journal

Complement Depletion Improves Human Red Blood Cell Reconstitution in Immunodeficient Mice

(2017) Bing Chen et al.   Stem Cell Reports

T Cell Lymphoma and Leukemia in Severe Combined Immunodeficiency Pigs following Bone Marrow Transplantation: A Case Report

(2017) Ellis J. Powell et al.   Frontiers in Immunology

Pigs with Severe Combined Immunodeficiency Are Impaired in Controlling Influenza A Virus Infection

(2016) Daniela S. Rajao et al.   Journal of Innate Immunity

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

(2016) Jung-Taek Kang et al.   Reproductive Biology and Endocrinology

Generation and characterization of RAG2 knockout pigs as animal model for severe combined immunodeficiency

(2016) Shunichi Suzuki et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene

(2016) Ellis J. Powell et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency

(2016) Shaohua Lei et al.   Scientific Reports

Engineered Swine Models of Cancer

(2016) Adrienne L. Watson et al.   Frontiers in Genetics

Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

(2016) Chris J. Jung et al.   Scientific Reports

Livestock Models in Translational Medicine

(2015) J. A. Roth et al.   ILAR JOURNAL

Not All SCID Pigs Are Created Equally: Two Independent Mutations in theArtemisGene Cause SCID in Pigs

(2015) Emily H. Waide et al.   JOURNAL OF IMMUNOLOGY

Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II

(2014) N. G. Sosale et al.   BLOOD

Influence of a dual-injection regimen, plerixafor and CXCR4 on in utero hematopoietic stem cell transplantation and engraftment with use of the sheep model

(2014) A. Daisy Goodrich et al.   CYTOTHERAPY

Signal-regulatory proteinαfrom the NOD mouse binds human CD47 with an exceptionally high affinity - implications for engraftment of human cells

(2014) Lai Shan Kwong et al.   IMMUNOLOGY

Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts

(2014) H. Kalscheuer et al.   JOURNAL OF IMMUNOLOGY

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment

(2013) T. Yamauchi et al.   BLOOD

Structural and functional annotation of the porcine immunome

(2013) Harry D Dawson et al.   BMC GENOMICS

Animal versus human oral drug bioavailability: Do they correlate?

(2013) Helen Musther et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment

(2013) Chika Iwamoto et al.   EXPERIMENTAL HEMATOLOGY

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

(2013) D. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD47 functions as a molecular switch for erythrocyte phagocytosis

(2012) P. Burger et al.   BLOOD

Il2rg Gene-Targeted Severe Combined Immunodeficiency Pigs

(2012) Shunichi Suzuki et al.   Cell Stem Cell

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in human and porcine platelet oligosaccharides may influence phagocytosis by liver sinusoidal cells in vitro

(2012) Leela L. Paris et al.   XENOTRANSPLANTATION

Macrophages prevent human red blood cell reconstitution in immunodeficient mice

(2011) Z. Hu et al.   BLOOD

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

(2011) Lynsey Fairbairn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pig: a model for human infectious diseases

(2011) François Meurens et al.   TRENDS IN MICROBIOLOGY

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia

(2010) Mark P. Chao et al.   CANCER RESEARCH

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

The fate of human platelets perfused through the pig liver: implications for xenotransplantation

(2010) Christopher Burlak et al.   XENOTRANSPLANTATION

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Signal regulatory protein alpha (SIRPα)/CD47 interaction and function

(2009) A Neil Barclay   CURRENT OPINION IN IMMUNOLOGY

Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with CD47

(2008) Deborah Hatherley et al.   MOLECULAR CELL

Toward Development and Production of Human T Cells in Swine for Potential Use in Adoptive T Cell Immunotherapy

(2008) Brenda M. Ogle et al.   TISSUE ENGINEERING PART A