Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse

Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity

(2016) Steven P. Broadley et al.   Cell Host & Microbe

Preferential association of hepatitis C virus with CD19+B cells is mediated by complement system

(2016) Richard Y. Wang et al.   HEPATOLOGY

Complement factor H interferes with Mycobacterium bovis BCG entry into macrophages and modulates the pro-inflammatory cytokine response

(2016) Munirah Abdul-Aziz et al.   IMMUNOBIOLOGY

More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation

(2016) George Hajishengallis et al.   IMMUNOLOGICAL REVIEWS

Distinct CD55 Isoform Synthesis and Inhibition of Complement-Dependent Cytolysis by Hepatitis C Virus

(2016) Young-Chan Kwon et al.   JOURNAL OF IMMUNOLOGY

Novel Evasion Mechanisms of the Classical Complement Pathway

(2016) Brandon L. Garcia et al.   JOURNAL OF IMMUNOLOGY

The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells

(2016) Rut Olivar et al.   JOURNAL OF IMMUNOLOGY

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement and Its Receptors: New Insights into Human Disease

(2014) V. Michael Holers   Annual Review of Immunology

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

Cutting Edge: Members of the Staphylococcus aureus Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2

(2014) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Complement Opsonization of HIV-1 Results in Decreased Antiviral and Inflammatory Responses in Immature Dendritic Cells via CR3

(2014) Rada Ellegård et al.   JOURNAL OF IMMUNOLOGY

Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation

(2014) Elizabeth V. Clarke et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Viral regulators of complement activation: Structure, function and evolution

(2014) Hina Ojha et al.   MOLECULAR IMMUNOLOGY

Intracellular sensing of complement C3 activates cell autonomous immunity

(2014) J. C. H. Tam et al.   SCIENCE

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation

(2013) Balthasar A. Heesters et al.   IMMUNITY

The  7 0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells

(2013) R. Olivar et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Human complement control and complement evasion by pathogenic microbes – Tipping the balance

(2013) Peter F. Zipfel et al.   MOLECULAR IMMUNOLOGY

West Nile virus infection and immunity

(2013) Mehul S. Suthar et al.   NATURE REVIEWS MICROBIOLOGY

Fine Tuning Inflammation at the Front Door: Macrophage Complement Receptor 3-mediates Phagocytosis and Immune Suppression for Francisella tularensis

(2013) Shipan Dai et al.   PLoS Pathogens

Protease-dependent mechanisms of complement evasion by bacterial pathogens

(2012) Michal Potempa et al.   BIOLOGICAL CHEMISTRY

DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells

(2012) K. K. Hosszu et al.   BLOOD

Regulation of Humoral Immunity by Complement

(2012) Michael C. Carroll et al.   IMMUNITY

Manipulating the mediator: Modulation of the alternative complement pathway C3 convertase in health, disease and therapy

(2012) Daniel Ricklin   IMMUNOBIOLOGY

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

The CD46-Jagged1 interaction is critical for human TH1 immunity

(2012) Gaëlle Le Friec et al.   NATURE IMMUNOLOGY

Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a

(2011) Ke Li et al.   IMMUNOBIOLOGY

Complement and non-complement activating functions of C1q: A prototypical innate immune molecule

(2011) Annapurna Nayak et al.   Innate Immunity

Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation

(2011) P. Avirutnan et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus Proteins Inhibit C3 Complement Production

(2011) B. Mazumdar et al.   JOURNAL OF VIROLOGY

Transcriptional Repression of C4 Complement by Hepatitis C Virus Proteins

(2011) A. Banerjee et al.   JOURNAL OF VIROLOGY

C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation

(2011) Boon King Teh et al.   MOLECULAR IMMUNOLOGY

Complement and viral pathogenesis

(2011) Kristina A. Stoermer et al.   VIROLOGY

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1

(2010) Panisadee Avirutnan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutational Analyses Reveal that the Staphylococcal Immune Evasion Molecule Sbi and Complement Receptor 2 (CR2) Share Overlapping Contact Residues on C3d: Implications for the Controversy Regarding the CR2/C3d Cocrystal Structure

(2010) David E. Isenman et al.   JOURNAL OF IMMUNOLOGY

The C5a Receptor Impairs IL-12-Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss

(2010) S. Liang et al.   JOURNAL OF IMMUNOLOGY

The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection

(2010) N. M. Girgis et al.   JOURNAL OF VIROLOGY

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

(2010) John Cardone et al.   NATURE IMMUNOLOGY

Microbial Hijacking of Complement-Toll-Like Receptor Crosstalk

(2010) M. Wang et al.   Science Signaling

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

HIV gp41 Engages gC1qR on CD4+ T Cells to Induce the Expression of an NK Ligand through the PIP3/H2O2 Pathway

(2010) Hugues Fausther-Bovendo et al.   PLoS Pathogens

Mycobacterium leprae Phenolglycolipid-1 Expressed by Engineered M. bovis BCG Modulates Early Interaction with Human Phagocytes

(2010) Guillaume Tabouret et al.   PLoS Pathogens

C1q enhances IFN-  production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells

(2009) P. Baruah et al.   BLOOD

Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection

(2009) Kara L. Cummings et al.   CLINICAL IMMUNOLOGY

C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells

(2009) Donald J. Weaver et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity

(2009) Kinga K. Hosszu et al.   Innate Immunity

Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA

(2009) J. Zhang et al.   JOURNAL OF GENERAL VIROLOGY

Staphylococcal Complement Inhibitor Modulates Phagocyte Responses by Dimerization of Convertases

(2009) Ilse Jongerius et al.   JOURNAL OF IMMUNOLOGY

CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages

(2009) C. Oliva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

Interaction of Human Complement with Sbi, a Staphylococcal Immunoglobulin-binding Protein

(2008) Julia D. Burman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes

(2008) C. R. Oliva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement–HIV interactions during all steps of viral pathogenesis

(2008) Heribert Stoiber et al.   VACCINE