Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB Pathway

Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling

(2017) Chenyan Li et al.   THYROID

Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury

(2016) Yanzhe Wang et al.   Drug Design Development and Therapy

Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses

(2015) Li Pang et al.   INFLAMMATION

The Blockade of NF-κB Activation by a Specific Inhibitory Peptide Has a Strong Neuroprotective Role in a Sprague-Dawley Rat Kernicterus Model

(2015) Mengwen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia

(2015) Ker Zhing Lok et al.   Journal of Neuroinflammation

Mechanical Thrombectomy for Acute Ischemic Stroke

(2015) Islam Y. Elgendy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation

(2015) Meiyan Sun et al.   Scientific Reports

A Phase I Trial to Evaluate the Multiple-Dose Safety and Antitumor Activity of Ursolic Acid Liposomes in Subjects with Advanced Solid Tumors

(2015) Zhengzi Qian et al.   Biomed Research International

Glycyrrhizin protects brain against ischemia–reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway

(2014) Jiancheng Zhang et al.   BRAIN RESEARCH

Candesartan and glycyrrhizin ameliorate ischemic brain damage through downregulation of the TLR signaling cascade

(2014) Waleed Barakat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ursolic acid alleviates early brain injury after experimental subarachnoid hemorrhage by suppressing TLR4-mediated inflammatory pathway

(2014) Tingting Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bioavailability and Activity of Natural Food Additive Triterpenoids as Influenced by Protein

(2014) Wei Peng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In Vitro and in Vivo Antitumor Effects of Folate-Targeted Ursolic Acid Stealth Liposome

(2014) Guang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

(2014) Mingjin Jiang et al.   Journal of Neuroinflammation

Toll-Like Receptors and Ischemic Brain Injury

(2014) Raffaella Gesuete et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ursolic acid reduces oxidative stress to alleviate early brain injury following experimental subarachnoid hemorrhage

(2014) Tingting Zhang et al.   NEUROSCIENCE LETTERS

Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats

(2014) Gu Gong et al.   PLoS One

Acute hyperglycemia worsens ischemic stroke-induced brain damage via high mobility group box-1 in rats

(2013) Jingyang Huang et al.   BRAIN RESEARCH

Identification of TLR downstream pathways in stroke patients

(2013) Dean Wu et al.   CLINICAL BIOCHEMISTRY

Differential effects of aging and sex on stroke induced inflammation across the lifespan

(2013) Bharti Manwani et al.   EXPERIMENTAL NEUROLOGY

An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies

(2013) Domenica Musumeci et al.   PHARMACOLOGY & THERAPEUTICS

Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke

(2013) Zhenjun Tan et al.   STROKE

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

(2013) Edward C. Jauch et al.   STROKE

Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway

(2012) Chang-lin Zhai et al.   ACTA PHARMACOLOGICA SINICA

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Protective Effect of Delayed Remote Limb Ischemic Postconditioning: Role of Mitochondrial KATP Channels in a Rat Model of Focal Cerebral Ischemic Reperfusion Injury

(2012) Jing Sun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Post-Ischemic Inflammation in the Brain

(2012) Takashi Shichita et al.   Frontiers in Immunology

Toll-like receptors in inflammation of the central nervous system

(2011) Yan Kong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

The stem cell potential of glia: lessons from reactive gliosis

(2011) Stefanie Robel et al.   NATURE REVIEWS NEUROSCIENCE

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

(2011) Yong-Jian Wang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia

(2009) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome

(2008) Vanja Basic Kes et al.   CLINICAL BIOCHEMISTRY

Spinal cord injury: Emerging beneficial role of reactive astrocytes’ migration

(2008) Francois Renault-Mihara et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra

(2008) V. Kaushal et al.   JOURNAL OF NEUROSCIENCE

Ursolic acid: An anti- and pro-inflammatory triterpenoid

(2008) Yasutaka Ikeda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY