Microbes, metabolites, and the gut–lung axis

Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells

(2018) Meng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma

(2018) Elliot Mathieu et al.   Frontiers in Physiology

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways

(2018) Céline Pattaroni et al.   Cell Host & Microbe

Colonocyte metabolism shapes the gut microbiota

(2018) Yael Litvak et al.   SCIENCE

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

Diet and microbiota in inflammatory bowel disease: The gut in disharmony

(2017) Davy C M Rapozo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice

(2017) Ira Ekmekciu et al.   Frontiers in Immunology

Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota

(2017) Tingting Chen et al.   Scientific Reports

The Microbiome and the Respiratory Tract

(2016) Robert P. Dickson et al.   Annual Review of Physiology

Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis

(2016) Chiaki Iwamura et al.   BLOOD

Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

(2016) Kamilla S. Josefsdottir et al.   BLOOD

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Lung-gut cross-talk: evidence, mechanisms and implications for the mucosal inflammatory diseases

(2016) M. K. Tulic et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The human gut microbiome in health: establishment and resilience of microbiota over a lifetime

(2016) Kacy Greenhalgh et al.   ENVIRONMENTAL MICROBIOLOGY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

The respiratory tract microbiome and lung inflammation: a two-way street

(2016) G B Huffnagle et al.   Mucosal Immunology

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

(2016) Kei E Fujimura et al.   NATURE MEDICINE

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

How colonization by microbiota in early life shapes the immune system

(2016) Thomas Gensollen et al.   SCIENCE

Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children

(2016) Katri Korpela et al.   Nature Communications

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

(2015) Ashish Gurav et al.   BIOCHEMICAL JOURNAL

The gut microbiome in health and in disease

(2015) Andrew B. Shreiner et al.   CURRENT OPINION IN GASTROENTEROLOGY

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases

(2015) Shannon L. Russell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

(2015) Christine M. Bassis et al.   mBio

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Fiber supplementation influences phylogenetic structure and functional capacity of the human intestinal microbiome: follow-up of a randomized controlled trial

(2014) Hannah D Holscher et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary effects on human gut microbiome diversity

(2014) Zhenjiang Xu et al.   BRITISH JOURNAL OF NUTRITION

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Prenatal and post-natal exposure to antibiotics and risk of asthma in childhood

(2014) J. Metsälä et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

(2014) Jian Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

(2014) Maria L. Balmer et al.   JOURNAL OF IMMUNOLOGY

Dietary Pectin–Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance ofPseudomonas aeruginosaLung Infection in Mice by Modulating Intestinal Microbiota and Immunity

(2014) Henry Bernard et al.   JOURNAL OF INFECTIOUS DISEASES

The Role of Macrophage Polarization in Infectious and Inflammatory Diseases

(2014) Adam C. Labonte et al.   MOLECULES AND CELLS

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

(2014) Eva S Gollwitzer et al.   NATURE MEDICINE

Diet and the development of the human intestinal microbiome

(2014) Noah Voreades et al.   Frontiers in Microbiology

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

(2013) Alison Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disturbed Intestinal Integrity in Patients With COPD

(2013) Erica P.A. Rutten et al.   CHEST

Low gut microbiota diversity in early infancy precedes asthma at school age

(2013) T. R. Abrahamsson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce

(2013) Alberto Yáñez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis

(2013) Lionel Rigottier-Gois   ISME Journal

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Compartmentalized and systemic control of tissue immunity by commensals

(2013) Yasmine Belkaid et al.   NATURE IMMUNOLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases

(2013) Hui Wang   WORLD JOURNAL OF GASTROENTEROLOGY

The Human Microbiome: Our Second Genome

(2012) Elizabeth A. Grice et al.   Annual Review of Genomics and Human Genetics

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Pulmonary dendritic cell development and antigen acquisition

(2012) A. Nicole Desch et al.   IMMUNOLOGIC RESEARCH

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Effects of Gut Microbes on Nutrient Absorption and Energy Regulation

(2012) Rosa Krajmalnik-Brown et al.   NUTRITION IN CLINICAL PRACTICE

Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota

(2012) A. F. Goddard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age

(2011) Hans Bisgaard et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

(2011) Hitoshi Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

(2011) S Keely et al.   Mucosal Immunology

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

The skin microbiome

(2011) Elizabeth A. Grice et al.   NATURE REVIEWS MICROBIOLOGY

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Shifting the balance: antibiotic effects on host–microbiota mutualism

(2011) Benjamin P. Willing et al.   NATURE REVIEWS MICROBIOLOGY

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Commensal Microflora Contribute to Host Defense Against Escherichia Coli Pneumonia Through Toll-Like Receptors

(2011) Lee-Wei Chen et al.   SHOCK

Gut Microbiota and Inflammation

(2011) Asa Hakansson et al.   Nutrients

Antibiotic Exposure by 6 Months and Asthma and Allergy at 6 Years: Findings in a Cohort of 1,401 US Children

(2010) K. R. Risnes et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

The Human Oral Microbiome

(2010) F. E. Dewhirst et al.   JOURNAL OF BACTERIOLOGY

Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4- and IFN-β-dependent

(2010) K A Shirey et al.   Mucosal Immunology

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Antibiotic Use in Children Is Associated With Increased Risk of Asthma

(2009) F. Marra et al.   PEDIATRICS

Rapid and Accurate Large-Scale Coestimation of Sequence Alignments and Phylogenetic Trees

(2009) K. Liu et al.   SCIENCE

Bacterial Community Variation in Human Body Habitats Across Space and Time

(2009) E. K. Costello et al.   SCIENCE

Hematopoietic cytokines

(2008) D. Metcalf   BLOOD

Acute intestinal obstruction as a presentation of cystic fibrosis in infancy

(2007) Vijay Baral et al.   Journal of Cystic Fibrosis