Pulmonary-intestinal cross-talk in mucosal inflammatory disease

Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease

(2016) Lynn Cotterill et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

Chlamydia muridarum Infection Subverts Dendritic Cell Function to Promote Th2 Immunity and Airways Hyperreactivity

(2014) G. E. Kaiko et al.   JOURNAL OF IMMUNOLOGY

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Control of Gene Expression in the Lung

(2011) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-6 Promotes Pulmonary Emphysema Associated with Apoptosis in Mice

(2011) Saleela M. Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study

(2011) Sally L Chappell et al.   BMC Medical Genetics

Cytokine/anti-cytokine therapy - novel treatments for asthma?

(2011) Philip M Hansbro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of increased CD8/CD28null T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease

(2011) G. Hodge et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

STAT6 Links IL-4/IL-13 Stimulation With Pendrin Expression in Asthma and Chronic Obstructive Pulmonary Disease

(2011) C Nofziger et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Recent Insights Into the Genetics of Inflammatory Bowel Disease

(2011) Judy H. Cho et al.   GASTROENTEROLOGY

STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colon epithelial cell dysfunction

(2011) Michael J. Rosen et al.   INFLAMMATORY BOWEL DISEASES

An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling

(2011) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-  and IL-6 and Promote Cigarette Smoke-Induced Emphysema

(2011) Z. Xiong et al.   JOURNAL OF IMMUNOLOGY

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT

(2011) Stephanie Verschuere et al.   LABORATORY INVESTIGATION

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD

(2011) John R. Erb-Downward et al.   PLoS One

Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease

(2011) María Inés Vargas-Rojas et al.   RESPIRATORY MEDICINE

Interleukin-13 Promotes Susceptibility to Chlamydial Infection of the Respiratory and Genital Tracts

(2011) Kelly L. Asquith et al.   PLoS Pathogens

Haemophilus influenzae Infection Drives IL-17-Mediated Neutrophilic Allergic Airways Disease

(2011) Ama-Tawiah Essilfie et al.   PLoS Pathogens

Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

(2010) Renat Shaykhiev et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers

(2010) Matthaios Speletas et al.   Clinical & Developmental Immunology

The Toll-Like Receptor 4 D299G and T399I Polymorphisms Are Associated with Crohn’s Disease and Ulcerative Colitis: A Meta-Analysis

(2010) Xiuyun Shen et al.   DIGESTION

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Body composition and plasma levels of inflammatory biomarkers in COPD

(2010) T. M. L. Eagan et al.   EUROPEAN RESPIRATORY JOURNAL

Genetics and Environmental Interactions Shape the Intestinal Microbiome to Promote Inflammatory Bowel Disease Versus Mucosal Homeostasis

(2010) R. Balfour Sartor   GASTROENTEROLOGY

Interleukin-6: a therapeutic Jekyll and Hyde in gastrointestinal and hepatic diseases

(2010) S. Danese et al.   GUT

Homing of immune cells: Role in homeostasis and intestinal inflammation

(2010) Ailsa L. Hart et al.   INFLAMMATORY BOWEL DISEASES

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

(2010) Jay C. Horvat et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Durable Alteration of the Colonic Microbiota by the Administration of Donor Fecal Flora

(2010) Martin J. Grehan et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Pulmonary manifestations of inflammatory bowel disease: Case presentations and review

(2010) Benjamin Basseri et al.   Journal of Crohns & Colitis

Inflammatory bowel disease in the Asia-Pacific area: A comparison with developed countries and regional differences

(2010) Vineet AHUJA et al.   Journal of Digestive Diseases

Cytotoxic Potential of Lung CD8+ T Cells Increases with Chronic Obstructive Pulmonary Disease Severity and with In Vitro Stimulation by IL-18 or IL-15

(2010) C. M. Freeman et al.   JOURNAL OF IMMUNOLOGY

Chronic Cigarette Smoke Exposure Primes NK Cell Activation in a Mouse Model of Chronic Obstructive Pulmonary Disease

(2010) G. T. Motz et al.   JOURNAL OF IMMUNOLOGY

Chlamydial Respiratory Infection during Allergen Sensitization Drives Neutrophilic Allergic Airways Disease

(2010) J. C. Horvat et al.   JOURNAL OF IMMUNOLOGY

A Persistent and Diverse Airway Microbiota Present during Chronic Obstructive Pulmonary Disease Exacerbations

(2010) Yvonne J. Huang et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Polymorphisms in the Tlr4 and Tlr5 Gene Are Significantly Associated with Inflammatory Bowel Disease in German Shepherd Dogs

(2010) Aarti Kathrani et al.   PLoS One

Systemic inflammation and comorbidity in COPD: a result of 'overspill' of inflammatory mediators from the lungs? Review of the evidence

(2010) N. J. Sinden et al.   THORAX

Infection, inflammation, and chronic diseases: consequences of a modern lifestyle

(2010) Stefan Ehlers et al.   TRENDS IN IMMUNOLOGY

Pulmonary involvement and allergic disorders in inflammatory bowel disease

(2010) Nikolaos E Tzanakis   WORLD JOURNAL OF GASTROENTEROLOGY

Differences in Genetic Background Between Active Smokers, Passive Smokers and Non-Smokers With Crohn's Disease

(2009) Frans van der Heide et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Integration of Genomic and Genetic Approaches Implicates IREB2 as a COPD Susceptibility Gene

(2009) Dawn L. DeMeo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis

(2009) Pallavi Garg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Persistent bronchiolar remodeling following brief ventilation of the very immature ovine lung

(2009) Megan O'Reilly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chemotactic Mediators of Th1 T-cell Trafficking in Smokers and COPD Patients

(2009) Sheree Brozyna et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Acute effects of tobacco smoke on human airway dendritic cells in vivo

(2009) M. Lommatzsch et al.   EUROPEAN RESPIRATORY JOURNAL

Systemic manifestations and comorbidities of COPD

(2009) P. J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study

(2009) Y. M. T. A. Van Durme et al.   EUROPEAN RESPIRATORY JOURNAL

A hypothesis for the initiation of COPD

(2009) E. G. Tzortzaki et al.   EUROPEAN RESPIRATORY JOURNAL

Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results

(2009) C. Crim et al.   EUROPEAN RESPIRATORY JOURNAL

IL13PROMOTER (-1055) POLYMORPHISMS ASSOCIATED WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN TAIWANESE

(2009) Shih-Feng Liu et al.   EXPERIMENTAL LUNG RESEARCH

Clustering in time of familial IBD separates ulcerative colitis from Crohnʼs disease

(2009) May-Bente Bengtson et al.   INFLAMMATORY BOWEL DISEASES

Overall and cause-specific mortality in Crohnʼs disease: A meta-analysis of population-based studies

(2009) Dana Duricova et al.   INFLAMMATORY BOWEL DISEASES

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages

(2009) Hadi Sarir et al.   Journal of Inflammation-London

Toll-Like Receptor 2 Gene Polymorphisms Arg677Trp and Arg753Gln in Chronic Obstructive Pulmonary Disease

(2009) Stefan Pabst et al.   LUNG

High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD

(2009) Alberto J. León et al.   MEDIATORS OF INFLAMMATION

Hypoxia-inducible Factor-dependent Regulation of Platelet-activating Factor Receptor as a Route for Gram-Positive Bacterial Translocation across Epithelia

(2009) Simon Keely et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

An unexpected twist for autophagy in Crohn's disease

(2009) Tamaki Yano et al.   NATURE IMMUNOLOGY

A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study

(2009) Jemma B. Wilk et al.   PLoS Genetics

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

(2009) Sreekumar G. Pillai et al.   PLoS Genetics

Function-Associated Surface Molecules on Airway Dendritic Cells in Cigarette Smokers

(2008) Kai Bratke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

COPD as a Lung Disease with Systemic Consequences – Clinical Impact, Mechanisms, and Potential for Early Intervention

(2008) Marc Decramer et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Cells, mediators and Toll-like receptors in COPD

(2008) Hadi Sarir et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intestinal barrier dysfunction in inflammatory bowel diseases

(2008) Michael A. McGuckin et al.   INFLAMMATORY BOWEL DISEASES

Antiflagellin antibodies recognize the autoantigens Toll-Like Receptor 5 and Pals 1-associated tight junction protein and induce monocytes activation and increased intestinal permeability in Crohn’s disease

(2008) C. Lunardi et al.   JOURNAL OF INTERNAL MEDICINE

Increased Risk of Both Ulcerative Colitis and Crohn’s Disease in a Population Suffering from COPD

(2008) Anders Ekbom et al.   LUNG

The molecular basis of NOD2 susceptibility mutations in Crohn's disease

(2008) W Strober et al.   Mucosal Immunology

The role of IL-13 and NK T cells in experimental and human ulcerative colitis

(2008) I J Fuss et al.   Mucosal Immunology

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

(2008) Sheila A Fisher et al.   NATURE GENETICS

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE

Understanding the mechanisms of viral induced asthma: New therapeutic directions

(2008) Nicole G. Hansbro et al.   PHARMACOLOGY & THERAPEUTICS

Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

(2008) Luciana Rigoli et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Immunological decision-making: how does the immune system decide to mount a helper T-cell response?

(2007) Gerard E. Kaiko et al.   IMMUNOLOGY