- Home
- Publications
- Publication Search
- Publication Details
Title
Neddylation: a novel modulator of the tumor microenvironment
Authors
Keywords
Neddylation, Tumor microenvironment, Tumor-derived factors, Cancer-associated fibroblasts, Cancer-associated endothelial cells, Immune cells
Journal
Molecular Cancer
Volume 18, Issue 1, Pages -
Publisher
Springer Nature
Online
2019-04-03
DOI
10.1186/s12943-019-0979-1
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML
- (2018) Ronan T. Swords et al. BLOOD
- FOXQ1/NDRG1 axis exacerbates hepatocellular carcinoma initiation via enhancing crosstalk between fibroblasts and tumor cells
- (2018) Qin Luo et al. CANCER LETTERS
- Protein neddylation and its alterations in human cancers for targeted therapy
- (2018) Lisha Zhou et al. CELLULAR SIGNALLING
- Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection
- (2018) Qianqian Cheng et al. PLoS Pathogens
- Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target
- (2017) Ping Xie et al. Cell Death & Disease
- Targeting Innate Immune Cells for Immunotherapy
- (2017) Leandro J. Carreño et al. Journal of Immunology Research
- SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses
- (2016) Nathan D. Mathewson et al. AMERICAN JOURNAL OF PATHOLOGY
- FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
- (2016) Xuguang Yang et al. CANCER RESEARCH
- Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4–CHOP–DR5 Axis in Human Esophageal Cancer Cells
- (2016) Ping Chen et al. CLINICAL CANCER RESEARCH
- A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma
- (2016) Shailender Bhatia et al. INVESTIGATIONAL NEW DRUGS
- Dendritic Cells and Cancer Immunity
- (2016) Alycia Gardner et al. TRENDS IN IMMUNOLOGY
- Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation
- (2016) Mengmeng Cheng et al. Oncotarget
- Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study
- (2015) Ronan T. Swords et al. BRITISH JOURNAL OF HAEMATOLOGY
- MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis
- (2015) Mohamed El-Mesery et al. BRITISH JOURNAL OF PHARMACOLOGY
- Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma
- (2015) J. J. Shah et al. CLINICAL CANCER RESEARCH
- Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors
- (2015) J. Sarantopoulos et al. CLINICAL CANCER RESEARCH
- Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages
- (2015) Stefano Ugel et al. JOURNAL OF CLINICAL INVESTIGATION
- Protein neddylation: beyond cullin–RING ligases
- (2015) Radoslav I. Enchev et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Suppression of glioblastoma by targeting the overactivated protein neddylation pathway
- (2015) Wei Hua et al. NEURO-ONCOLOGY
- T cell exclusion, immune privilege, and the tumor microenvironment
- (2015) J. A. Joyce et al. SCIENCE
- Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
- (2015) G. Wang et al. Cancer Discovery
- Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target
- (2015) Qiang Gao et al. Oncotarget
- Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression
- (2015) Lijun Jia et al. NEOPLASIA
- Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application
- (2015) Yongchao Zhao et al. NEOPLASIA
- Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy
- (2014) Yongchao Zhao et al. ANTIOXIDANTS & REDOX SIGNALING
- Ubiquitination by SAG regulates macrophage survival/death and immune response during infection
- (2014) S C Chang et al. CELL DEATH AND DIFFERENTIATION
- Tumor-Associated Macrophages: From Mechanisms to Therapy
- (2014) Roy Noy et al. IMMUNITY
- Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
- (2014) Hua Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Fibroblast heterogeneity in the cancer wound
- (2014) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Hypoxia and Hypoxia-Inducible Factor-1 Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function
- (2014) J. Jantsch et al. JOURNAL OF IMMUNOLOGY
- Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer
- (2014) Lihui Li et al. JNCI-Journal of the National Cancer Institute
- The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells
- (2014) Nengming Xiao et al. NATURE IMMUNOLOGY
- Suppression of tumor angiogenesis by targeting the protein neddylation pathway
- (2014) W-T Yao et al. Cell Death & Disease
- The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
- (2014) Ping Xie et al. Nature Communications
- Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment
- (2014) Theerawut Chanmee et al. Cancers
- Neddylation pathway regulates the proliferation and survival of macrophages
- (2013) Lihui Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Neddylation plays an important role in the regulation of murine and human dendritic cell function
- (2013) N. Mathewson et al. BLOOD
- Cullin-RING Ligases as Attractive Anti-cancer Targets
- (2013) Yongchao Zhao et al. CURRENT PHARMACEUTICAL DESIGN
- The complexity of NF-κB signaling in inflammation and cancer
- (2013) Bastian Hoesel et al. Molecular Cancer
- Influence of tumour micro-environment heterogeneity on therapeutic response
- (2013) Melissa R. Junttila et al. NATURE
- The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth
- (2012) Z. Luo et al. CANCER RESEARCH
- Targeting the Tumor Microenvironment for Cancer Therapy
- (2012) N. E. Sounni et al. CLINICAL CHEMISTRY
- MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy
- (2012) Steffan T Nawrocki et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Regulation of NF-κB by ubiquitination and degradation of the IκBs
- (2012) Naama Kanarek et al. IMMUNOLOGICAL REVIEWS
- Cancer-associated fibroblasts as targets for immunotherapy
- (2012) Sunitha Kakarla et al. Immunotherapy
- Inhibition of Neddylation Represses Lipopolysaccharide-induced Proinflammatory Cytokine Production in Macrophage Cells
- (2012) Fang-Mei Chang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling
- (2012) H.-s. Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SCF E3 Ubiquitin Ligases as Anticancer Targets
- (2011) L. Jia et al. CURRENT CANCER DRUG TARGETS
- Non-canonical NF-κB signaling activation and regulation: principles and perspectives
- (2011) Bahram Razani et al. IMMUNOLOGICAL REVIEWS
- mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR
- (2011) Daming Gao et al. MOLECULAR CELL
- MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma
- (2010) M. A. Milhollen et al. BLOOD
- Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia
- (2010) R. T. Swords et al. BLOOD
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
- (2010) Neta Erez et al. CANCER CELL
- Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ
- (2010) James E. Brownell et al. MOLECULAR CELL
- Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection
- (2010) I. K. Jang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-
- (2010) M. Kraman et al. SCIENCE
- RING Domain E3 Ubiquitin Ligases
- (2009) Raymond J. Deshaies et al. Annual Review of Biochemistry
- T Cell Activation
- (2009) Jennifer E. Smith-Garvin et al. Annual Review of Immunology
- ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence
- (2009) L. Jia et al. CANCER RESEARCH
- Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization
- (2009) J. Merlet et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer
- (2009) T. A. Soucy et al. CLINICAL CANCER RESEARCH
- Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement
- (2009) Yuezhou Chen et al. MOLECULAR CELL
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1
- (2008) Dimitris P. Xirodimas BIOCHEMICAL SOCIETY TRANSACTIONS
- Divergent effects of hypoxia on dendritic cell functions
- (2008) A. Mancino et al. BLOOD
- Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
- (2008) David M. Duda et al. CELL
- Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
- (2008) Weiping Cao et al. NATURE IMMUNOLOGY
- The tumor microenvironment and its role in promoting tumor growth
- (2008) T L Whiteside ONCOGENE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now