Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target

SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor

(2016) Li-Sheng Zheng et al.   CANCER RESEARCH

Nasopharyngeal carcinoma

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Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells

(2015) Yanchun Wang et al.   CANCER BIOLOGY & THERAPY

MLN4924, a novel protein neddylation inhibitor, suppresses proliferation and migration of human urothelial carcinoma: In vitro and in vivo studies

(2015) Kuan-Lin Kuo et al.   CANCER LETTERS

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis

(2015) Li Qin et al.   Oncotarget

Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy

(2014) Yongchao Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging therapies targeting the ubiquitin proteasome system in cancer

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Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer

(2014) Lihui Li et al.   JNCI-Journal of the National Cancer Institute

Suppression of tumor angiogenesis by targeting the protein neddylation pathway

(2014) W-T Yao et al.   Cell Death & Disease

Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway

(2013) Chang-Fu Yang et al.   CANCER LETTERS

Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma

(2013) M.-s. Wu et al.   MOLECULAR CANCER THERAPEUTICS

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

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As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial–mesenchymal transition and activation of AKT signaling

(2012) Xin-Jian Li et al.   CARCINOGENESIS

Inhibition of NEDD8-conjugation pathway by novel molecules: Potential approaches to anticancer therapy

(2012) Tomoaki Tanaka et al.   Molecular Oncology

The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

(2012) Dong Yang et al.   PLoS One

Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

(2011) D. Wei et al.   CANCER RESEARCH

Serglycin Is a Theranostic Target in Nasopharyngeal Carcinoma that Promotes Metastasis

(2011) X.-J. Li et al.   CANCER RESEARCH

Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer

(2011) A. D. Steg et al.   CLINICAL CANCER RESEARCH

Modern treatment for nasopharyngeal carcinoma: current status and prospects

(2011) Sylvie Rottey et al.   CURRENT OPINION IN ONCOLOGY

Inactivation of SAG E3 Ubiquitin Ligase Blocks Embryonic Stem Cell Differentiation and Sensitizes Leukemia Cells to Retinoid Acid

(2011) Mingjia Tan et al.   PLoS One

The prevalence and prevention of nasopharyngeal carcinoma in China

(2011) Su-Mei Cao et al.   Chinese Journal of Cancer

Drug discovery and assay development in the ubiquitin–proteasome system

(2010) Celia R. Berkers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Tumor initiating cells in malignant gliomas: biology and implications for therapy

(2009) Costas G. Hadjipanayis et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1

(2008) Dimitris P. Xirodimas   BIOCHEMICAL SOCIETY TRANSACTIONS

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

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