Microglia roles in synaptic plasticity and myelination in homeostatic conditions and neurodevelopmental disorders

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

(2019) Carl M. Sellgren et al.   NATURE NEUROSCIENCE

Rab GTPases and Membrane Trafficking in Neurodegeneration

(2018) Ferdi Ridvan Kiral et al.   CURRENT BIOLOGY

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes

(2018) Carmen Mecca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

(2018) Haitham Amal et al.   MOLECULAR PSYCHIATRY

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

(2018) Michael J. Gandal et al.   SCIENCE

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Maternal immune activation altered microglial immunoreactivity in the brain of postnatal day 2 rat offspring

(2018) Jiaxian Zhang et al.   SYNAPSE

Interactions Between Neural Progenitor Cells and Microglia in the Subventricular Zone: Physiological Implications in the Neurogenic Niche and After Implantation in the Injured Brain

(2018) Esperanza R. Matarredona et al.   Frontiers in Cellular Neuroscience

Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

(2018) Jung Won Kim et al.   Clinical Psychopharmacology and Neuroscience

Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations

(2018) Janos Groh et al.   GLIA

Regulation of myelin structure and conduction velocity by perinodal astrocytes

(2018) Dipankar J. Dutta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia and early brain development: An intimate journey

(2018) Morgane S. Thion et al.   SCIENCE

Microglia ablation alleviates myelin-associated catatonic signs in mice

(2017) Hana Janova et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination

(2017) Veronique E. Miron   JOURNAL OF LEUKOCYTE BIOLOGY

Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala

(2017) Elaine O’Loughlin et al.   Journal of Neuroinflammation

SHANK proteins: roles at the synapse and in autism spectrum disorder

(2017) Patricia Monteiro et al.   NATURE REVIEWS NEUROSCIENCE

Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease

(2017) Stefan Wendt et al.   NEUROBIOLOGY OF AGING

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism

(2017) Miao Wang et al.   Neuroscience Bulletin

Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder

(2017) Anne Masi et al.   Molecular Autism

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

(2017) K Ishizuka et al.   Translational Psychiatry

Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review

(2017) Deepa Anand et al.   Frontiers in Psychiatry

Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey

(2017) Eli Shobin et al.   GeroScience

A Case Series of a Luteolin Formulation (Neuroprotek®) in Children with Autism Spectrum Disorders

(2017) T.C. Theoharides et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Transcriptome Analysis of the Human Striatum in Tourette Syndrome

(2016) Jessica B. Lennington et al.   BIOLOGICAL PSYCHIATRY

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies

(2016) Sandra Giovanoli et al.   BRAIN BEHAVIOR AND IMMUNITY

Beneficial Effects of Co-Ultramicronized Palmitoylethanolamide/Luteolin in a Mouse Model of Autism and in a Case Report of Autism

(2016) Bartolomeo Bertolino et al.   CNS Neuroscience & Therapeutics

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Neurobiology of social behavior abnormalities in autism and Williams syndrome

(2016) Boaz Barak et al.   NATURE NEUROSCIENCE

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness

(2016) Marilia A. Calcia et al.   PSYCHOPHARMACOLOGY

Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging

(2016) Ana I. Rodriguez-Perez et al.   Oncotarget

Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse

(2015) Kimberley A. Jones et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia function during brain development: New insights from animal models

(2015) Parizad M. Bilimoria et al.   BRAIN RESEARCH

Altered white matter connectivity as a neural substrate for social impairment in Autism Spectrum Disorder

(2015) Stephanie H. Ameis et al.   CORTEX

Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

(2015) Paul D. Wes et al.   GLIA

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

TMEM119 marks a subset of microglia in the human brain

(2015) Jun-ichi Satoh et al.   NEUROPATHOLOGY

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

(2015) Susan L. Patterson   NEUROPHARMACOLOGY

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia

(2015) Marie-Ève Tremblay et al.   Frontiers in Neuroanatomy

18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination

(2015) Jieru Zhou et al.   Scientific Reports

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Microglia shape corpus callosum axon tract fasciculation: functional impact of prenatal inflammation

(2014) Lorena Pont-Lezica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pattern recognition receptors and central nervous system repair

(2014) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy

(2014) Aaron J Schain et al.   NATURE MEDICINE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Fine-tuning the central nervous system: microglial modelling of cells and synapses

(2014) A. L. Xavier et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

(2014) Cristina Limatola et al.   Frontiers in Cellular Neuroscience

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

(2014) Rosa Chiara Paolicelli et al.   Frontiers in Cellular Neuroscience

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

(2014) Simone Gupta et al.   Nature Communications

Myelination and Oligodendrocyte Functions in Psychiatric Diseases

(2014) Klaus-Armin Nave et al.   JAMA Psychiatry

Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum

(2014) Catherine Edmonson et al.   Molecular Autism

Toll-like receptors as developmental tools that regulate neurogenesis during development: an update

(2014) Boaz Barak et al.   Frontiers in Neuroscience

Are “Resting” Microglia More “M2”?

(2014) Jonathan D. Cherry et al.   Frontiers in Immunology

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders

(2013) Anilia Taliou et al.   CLINICAL THERAPEUTICS

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

(2013) Dorothy P. Schafer et al.   CURRENT OPINION IN NEUROBIOLOGY

Mechanisms and therapeutic challenges in autism spectrum disorders

(2013) Jorge Castro et al.   CURRENT OPINION IN NEUROLOGY

Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury

(2013) Yu-Kai Zhang et al.   Journal of Neuroinflammation

Oligodendrocyte Lineage Cells Contribute Unique Features to Rett Syndrome Neuropathology

(2013) M. V. C. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

(2013) Gary P. Morris et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure

(2013) Katrin Deinhardt et al.   NEUROPHARMACOLOGY

Glial Biology in Learning and Cognition

(2013) R. Douglas Fields et al.   NEUROSCIENTIST

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

(2013) S. Ricci et al.   NEUROTOXICITY RESEARCH

Microglia Actively Regulate the Number of Functional Synapses

(2013) Kyungmin Ji et al.   PLoS One

Differential Modulation of TREM2 Protein during Postnatal Brain Development in Mice

(2013) Mariela Chertoff et al.   PLoS One

Catatonia in DSM-5

(2013) Rajiv Tandon et al.   SCHIZOPHRENIA RESEARCH

Microglial control of neuronal activity

(2013) Catherine Béchade et al.   Frontiers in Cellular Neuroscience

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development

(2012) Paula A. Garay et al.   BRAIN BEHAVIOR AND IMMUNITY

Abnormal microglial–neuronal spatial organization in the dorsolateral prefrontal cortex in autism

(2012) John T. Morgan et al.   BRAIN RESEARCH

A myelin gene causative of a catatonia-depression syndrome upon aging

(2012) Nora Hagemeyer et al.   EMBO Molecular Medicine

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

(2012) S G Fillman et al.   MOLECULAR PSYCHIATRY

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Evidence for a Developmental Role for TLR4 in Learning and Memory

(2012) Eitan Okun et al.   PLoS One

Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice

(2012) T. Sadakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

(2012) V. Ramaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Inflammation and neurodegeneration: the story ‘retolled’

(2012) Janelle Drouin-Ouellet et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microglial Activation in Young Adults With Autism Spectrum Disorder

(2012) Katsuaki Suzuki et al.   JAMA Psychiatry

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity

(2011) James B Adams et al.   BMC GASTROENTEROLOGY

IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation

(2011) Hongen Wei et al.   Journal of Neuroinflammation

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment

(2011) Laura Maggi   Frontiers in Cellular Neuroscience

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

(2010) John T. Morgan et al.   BIOLOGICAL PSYCHIATRY

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits

(2010) Laurence Garey   JOURNAL OF ANATOMY

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Beneficial Effects of Minocycline on Cuprizone Induced Cortical Demyelination

(2010) Thomas Skripuletz et al.   NEUROCHEMICAL RESEARCH

The Basics of Brain Development

(2010) Joan Stiles et al.   NEUROPSYCHOLOGY REVIEW

Cognitive and social functions and growth factors in a mouse model of Rett syndrome

(2010) Laura R. Schaevitz et al.   PHYSIOLOGY & BEHAVIOR

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Microglia in Infectious Diseases of the Central Nervous System

(2009) Monica M. Mariani et al.   Journal of Neuroimmune Pharmacology

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)

(2009) Laura Maggi et al.   JOURNAL OF NEUROIMMUNOLOGY

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Epidemiology of Pervasive Developmental Disorders

(2009) Eric Fombonne   PEDIATRIC RESEARCH

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

(2009) Daniela Tropea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IMMUNOLOGY: Dangers In and Out

(2009) M. E. Bianchi et al.   SCIENCE

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Molecular mechanisms of phagocytic uptake in mammalian cells

(2008) E. Groves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endogenous signals initiating inflammation in the injured nervous system

(2008) Isabelle Pineau et al.   GLIA

A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS

(2008) Binith Cheeran et al.   JOURNAL OF PHYSIOLOGY-LONDON

Complement Receptor 1: Disease associations and therapeutic implications

(2008) Rohan Khera et al.   MOLECULAR IMMUNOLOGY

Microglial clearance function in health and disease

(2008) I. Napoli et al.   NEUROSCIENCE

Brain inflammation and adult neurogenesis: The dual role of microglia

(2008) C.T. Ekdahl et al.   NEUROSCIENCE

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH