Actively targeted nanocarriers for drug delivery to cancer cells

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Doxorubicin and Anti-PD-L1 Antibody Conjugated Gold Nanoparticles for Colorectal Cancer Photochemotherapy

(2019) Fakhrossadat Emami et al.   MOLECULAR PHARMACEUTICS

Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer

(2019) Ping Zhou et al.   BIOMATERIALS

Erythroid-Progenitor-Targeted Gene Therapy Using Bifunctional TFR1 Ligand-Peptides in Human Erythropoietic Protoporphyria

(2019) Arienne Mirmiran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth

(2019) Jiayan Lang et al.   ACS Nano

Engineering of Bone- and CD44-Dual-Targeting Redox-Sensitive Liposomes for the Treatment of Orthotopic Osteosarcoma

(2019) Shuaishuai Feng et al.   ACS Applied Materials & Interfaces

Prostate-Specific Membrane Antigen Targeted Gold Nanoparticles for Theranostics of Prostate Cancer

(2018) Joey Dacula Mangadlao et al.   ACS Nano

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumours

(2018) Qin Dai et al.   ACS Nano

Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice

(2018) Haowen Li et al.   DRUG DELIVERY

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

(2018) M.J. Ramalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Transferrin modified ruthenium nanoparticles with good biocompatibility for photothermal tumor therapy

(2018) Shuang Zhao et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

(2018) Daquan Wang et al.   Nanoscale

Fully Artificial Exosomes: Towards New Theranostic Biomaterials

(2018) Pablo García-Manrique et al.   TRENDS IN BIOTECHNOLOGY

Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation

(2018) Wei Deng et al.   Nature Communications

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

(2018) Fred C. Lam et al.   Nature Communications

Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy

(2018) Zhen Fan et al.   Nature Communications

Lymphoma-targeted treatment using a folic acid-decorated vincristine-loaded drug delivery system

(2018) Lei Qiu et al.   Drug Design Development and Therapy

Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?

(2018) Kulmira Nurgali et al.   Frontiers in Pharmacology

Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer

(2018) Karen A. Autio et al.   JAMA Oncology

Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics

(2018) Ruth A. Mitchell et al.   EXPERIMENTAL CELL RESEARCH

A triple modality BSA-coated dendritic nanoplatform for NIR imaging, enhanced tumor penetration and anticancer therapy

(2018) Jie Cao et al.   Nanoscale

Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

(2018) Inna M. Yasinska et al.   Nanoscale

Growing gold nanostructures for shape-selective cellular uptake

(2018) Sulalit Bandyopadhyay et al.   Nanoscale Research Letters

Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

(2018) Francesco Roncato et al.   Nature Communications

Imaging and therapy of ovarian cancer: clinical application of nanoparticles and future perspectives

(2018) Giovanni Di Lorenzo et al.   Theranostics

Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents

(2018) Rajendran JC Bose et al.   ACS Nano

Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 (BRCA2) Mutation

(2018) Chong Du et al.   ACS Nano

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study

(2018) Pamela Munster et al.   BRITISH JOURNAL OF CANCER

Bioactive Nanoparticles for Cancer Immunotherapy

(2018) Suchithra Poilil Surendran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice

(2018) Blendi Ura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decapeptide functionalized targeted mesoporous silica nanoparticles with doxorubicin exhibit enhanced apoptotic effect in breast and prostate cancer cells

(2018) Prajakta Tambe et al.   International Journal of Nanomedicine

Activation of polymeric nanoparticle intracellular targeting overcomes chemodrug resistance in human primary patient breast cancer cells

(2018) Amoura Abou-El-Naga et al.   International Journal of Nanomedicine

Folic acid receptor-targeted human serum albumin nanoparticle formulation of cabazitaxel for tumor therapy

(2018) Yating Sun et al.   International Journal of Nanomedicine

Macro-nanomedicine: Targeting the big picture

(2018) Twan Lammers   JOURNAL OF CONTROLLED RELEASE

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

(2018) Qinqin Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distinction Between Active and Passive Targeting of Nanoparticles Dictate Their Overall Therapeutic Efficacy

(2018) Tristan D. Clemons et al.   LANGMUIR

Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer

(2018) Feng Chen et al.   Nature Communications

PLGA-Based Nanoparticles in Cancer Treatment

(2018) Sima Rezvantalab et al.   Frontiers in Pharmacology

Biotin functionalized PEGylated poly(amidoamine) dendrimer conjugate for active targeting of paclitaxel in cancer

(2018) Sri Vishnu Kiran Rompicharla et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Smart copolymer coated SPIONs for colon cancer chemotherapy

(2018) Mariano Licciardi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Encapsulation of monomyristin into polymeric nanoparticles improved its in vitro antiproliferative activity against cervical cancer cells

(2018) Sirirat Boondireke et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

(2017) Jing Zhang et al.   International Journal of Nanomedicine

Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond

(2017) Samir Mitragotri et al.   JOURNAL OF CONTROLLED RELEASE

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

(2017) Nico van Zandwijk et al.   LANCET ONCOLOGY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

(2017) Hengfeng Yuan et al.   Nature Nanotechnology

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

(2017) Yuanzeng Min et al.   Nature Nanotechnology

Poly(vinyl alcohol) as a water protecting agent for silver nanoparticles: the role of polymer size and structure

(2017) Alexander Kyrychenko et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer

(2017) Orielyz Flores et al.   Theranostics

Photothermal Ablation of Cancer Cells Using Folate-Coated Gold/ Graphene Oxide Composite

(2017) Nicolò Mauro et al.   Current Drug Delivery

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

Formulation and dosage of therapeutic nanosuspension for active targeting of docetaxel (WO 2014210485A1)

(2016) Deep Pooja et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

(2016) Amrita Banerjee et al.   JOURNAL OF CONTROLLED RELEASE

Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study

(2016) Kathleen F Pirollo et al.   MOLECULAR THERAPY

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Targeting folate receptor alpha for cancer treatment

(2016) Anthony Cheung et al.   Oncotarget

Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer

(2016) Fangyuan Zhou et al.   Theranostics

Clearance Pathways and Tumor Targeting of Imaging Nanoparticles

(2015) Mengxiao Yu et al.   ACS Nano

Targeting Tumor Vasculature with Aptamer-Functionalized Doxorubicin–Polylactide Nanoconjugates for Enhanced Cancer Therapy

(2015) Li Tang et al.   ACS Nano

Targeting the folate receptor: diagnostic and therapeutic approaches to personalize cancer treatments

(2015) J. A. Ledermann et al.   ANNALS OF ONCOLOGY

Applications of nanoparticles in cancer medicine and beyond: optical and multimodalin vivoimaging, tissue targeting and drug delivery

(2015) Stefania Biffi et al.   Expert Opinion on Drug Delivery

Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging

(2015) Micah D. K. Glasgow et al.   Journal of Biomedical Nanotechnology

First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma

(2015) James R. Whittle et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

(2015) Behdokht Bahrami et al.   TUMOR BIOLOGY

Receptor-Mediated Drug Delivery Systems Targeting to Glioma

(2015) Shanshan Wang et al.   Nanomaterials

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study

(2014) M Köbel et al.   BRITISH JOURNAL OF CANCER

Development and Screening of a Series of Antibody-Conjugated and Silica-Coated Iron Oxide Nanoparticles for Targeting the Prostate-Specific Membrane Antigen

(2014) Amarnath Mukherjee et al.   ChemMedChem

Cancer-related fatigue—mechanisms, risk factors and treatments

(2014) Julienne E. Bower   Nature Reviews Clinical Oncology

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

(2014) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas

(2014) Alessia Calzolari et al.   Translational Oncology

Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

(2014) Caiguo Zhang et al.   Protein & Cell

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Personalized Cancer Medicine: Molecular Diagnostics, Predictive biomarkers, and Drug Resistance

(2013) D Gonzalez de Castro et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Proper design of silica nanoparticles combines high brightness, lack of cytotoxicity and efficient cell endocytosis

(2013) Enrico Rampazzo et al.   Nanoscale

Is it time for a new paradigm for systemic cancer treatment? Lessons from a century of cancer chemotherapy

(2013) Sarah Crawford   Frontiers in Pharmacology

Liposome imaging agents in personalized medicine

(2012) Anncatrine L. Petersen et al.   ADVANCED DRUG DELIVERY REVIEWS

Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study

(2012) Christoph Mamot et al.   LANCET ONCOLOGY

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

(2011) Tracy R. Daniels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Serous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-response

(2011) Yu-Li Chen et al.   Molecular Oncology

Interactions of Human Endothelial Cells with Gold Nanoparticles of Different Morphologies

(2011) Dorota Bartczak et al.   Small

Rexin-G, a targeted genetic medicine for cancer

(2010) Erlinda M Gordon et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic®P85, anin vitrocell line andin vivobiodistribution studies on rat model

(2009) Neha Shah et al.   JOURNAL OF DRUG TARGETING

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

(2008) Karsten Ulbrich et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS