Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 511, Issue -, Pages 325-334Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2017.10.023
Keywords
Transferrin; Ru nanoparticles; Tumor target; Photothermal therapy
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Funding
- National Natural Science Foundation of China [21171070, 21371075]
- Natural Science Foundation of Guangdong Province [2014A030311025]
- Planned Item of Science and Technology of Guangdong Province [2016A020217011]
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In the past two decades, there were various kinds of photothermal agents being synthesised and investigated for their photothermal effect in antitumor applications. However, it is barely reported that the photothermal effect of Ruthenium (Ru) nanoparticles was researched in depth. In this work, we introduced Ru nanoparticles which possess excellent biocompatibility and metabolize easily to the photothermal therapy field. In addition, to improve the cells capacity of absorbing Ru nanoparticles, these Ru nanoparticles were modified by transferrin (Tf-RuNPs). Subsequently, as is expected, the RuNPs exhibit a remarkably integrated and high-quality photothermal property. On the other hand, it is significantly that Tf modification could also strengthen the cells absorptive ability to uptake Ru nanoparticles through endocytosis., Furthermore, both the in vitro cell ablation and in vivo tumor treatment verified that the Tf-RuNPs became ideal photothermal agents for photothermal tumor ablation therapy owing to their low toxicity and high cell destruction capability. (c) 2017 Elsevier Inc. All rights reserved.
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