Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer

64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents

(2017) Luke Yongkyu Kwon et al.   MOLECULAR PHARMACEUTICS

Fabrication, characterization and biological evaluation of anti-HER2 indocyanine green-doxorubicin-encapsulated PEG-b-PLGA copolymeric nanoparticles for targeted photochemotherapy of breast cancer cells

(2017) Yu-Hsiang Lee et al.   Scientific Reports

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Imaging Diagnostic and Therapeutic Targets: Human Epidermal Growth Factor Receptor 2

(2016) G. Gebhart et al.   JOURNAL OF NUCLEAR MEDICINE

Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer Using 89Zr-Trastuzumab PET/CT

(2016) G. A. Ulaner et al.   JOURNAL OF NUCLEAR MEDICINE

Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients

(2016) M. Sandstrom et al.   JOURNAL OF NUCLEAR MEDICINE

[89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer

(2016) Richard Laforest et al.   MOLECULAR IMAGING AND BIOLOGY

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody–Drug Conjugates Using Click Cycloaddition Chemistry

(2015) Michael P. VanBrunt et al.   BIOCONJUGATE CHEMISTRY

Control of Ultrasmall Sub-10 nm Ligand-Functionalized Fluorescent Core–Shell Silica Nanoparticle Growth in Water

(2015) Kai Ma et al.   CHEMISTRY OF MATERIALS

Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma

(2015) M. Keyaerts et al.   JOURNAL OF NUCLEAR MEDICINE

Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging

(2015) Kengo Kanazaki et al.   Nanomedicine-Nanotechnology Biology and Medicine

Orientation and density control of bispecific anti-HER2 antibody on functionalized carbon nanotubes for amplifying effective binding reactivity to cancer cells

(2015) Hye-In Kim et al.   Nanoscale

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

(2015) Alexander Rouvinski et al.   NATURE

Molecular imaging using PET for breast cancer

(2015) Hiroaki Kurihara et al.   Breast Cancer

Pyrrolysyl-tRNA synthetase: An ordinary enzyme but an outstanding genetic code expansion tool

(2014) Wei Wan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Gallium-68-Labeled Anti-HER2 Single-Chain Fv Fragment: Development and In Vivo Monitoring of HER2 Expression

(2014) Masashi Ueda et al.   MOLECULAR IMAGING AND BIOLOGY

In Vivo Tumor Vasculature Targeted PET/NIRF Imaging with TRC105(Fab)-Conjugated, Dual-Labeled Mesoporous Silica Nanoparticles

(2014) Feng Chen et al.   MOLECULAR PHARMACEUTICS

Evaluation of 89Zr-pertuzumab in Breast Cancer Xenografts

(2014) Bernadette V. Marquez et al.   MOLECULAR PHARMACEUTICS

Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe

(2014) E. Phillips et al.   Science Translational Medicine

Tumor Vasculature Targeting: A Generally Applicable Approach for Functionalized Nanomaterials

(2014) Feng Chen et al.   Small

Current Approaches and Challenges in Monitoring Treatment Responses in Breast Cancer

(2014) Lindsey J. Graham et al.   Journal of Cancer

In Vivo Tumor Targeting and Image-Guided Drug Delivery with Antibody-Conjugated, Radiolabeled Mesoporous Silica Nanoparticles

(2013) Feng Chen et al.   ACS Nano

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Current Status of Anti–Human Epidermal Growth Factor Receptor 2 Therapies: Predicting and Overcoming Herceptin Resistance

(2013) Alice Chung et al.   Clinical Breast Cancer

64Cu-DOTA-Trastuzumab PET Imaging in Patients with HER2-Positive Breast Cancer

(2013) K. Tamura et al.   JOURNAL OF NUCLEAR MEDICINE

Site-specific antibody drug conjugates for cancer therapy

(2013) Siler Panowski et al.   mAbs

Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumors

(2012) Bart Cornelissen et al.   BIOMATERIALS

Odyssey of a cancer nanoparticle: From injection site to site of action

(2012) Joseph W. Nichols et al.   Nano Today

HER2 Protein and Gene Variation between Primary and Metastatic Breast Cancer: Significance and Impact on Patient Care

(2011) A. Fabi et al.   CLINICAL CANCER RESEARCH

Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma

(2011) Miriam Benezra et al.   JOURNAL OF CLINICAL INVESTIGATION

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

In vivo biodistribution and accumulation of 89Zr in mice

(2011) Diane S. Abou et al.   NUCLEAR MEDICINE AND BIOLOGY

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Biodistribution of 89Zr-trastuzumab and PET Imaging of HER2-Positive Lesions in Patients With Metastatic Breast Cancer

(2010) E C Dijkers et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A HER2-binding Affibody molecule labelled with 68Ga for PET imaging: direct in vivo comparison with the 111In-labelled analogue

(2010) Vladimir Tolmachev et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Molecular Imaging of HER2-Expressing Malignant Tumors in Breast Cancer Patients Using Synthetic 111In- or 68Ga-Labeled Affibody Molecules

(2010) R. P. Baum et al.   JOURNAL OF NUCLEAR MEDICINE

The HER2 testing conundrum

(2010) Malorye Allison   NATURE BIOTECHNOLOGY

Guidelines for Human Epidermal Growth Factor Receptor 2 Testing: Biologic and Methodologic Considerations

(2009) Guido Sauter et al.   JOURNAL OF CLINICAL ONCOLOGY

Unraveling the Biologic and Clinical Complexities of HER2

(2008) John W. Park et al.   Clinical Breast Cancer

Breast cancer imaging: A perspective for the next decade

(2008) Andrew Karellas et al.   MEDICAL PHYSICS

Targeted Tumor Cell Internalization and Imaging of Multifunctional Quantum Dot-Conjugated Immunoliposomes in Vitro and in Vivo

(2008) Kevin C. Weng et al.   NANO LETTERS

Fluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine

(2008) Andrew A. Burns et al.   NANO LETTERS

Does a targeting ligand influence nanoparticle tumor localization or uptake?

(2008) Kathleen F. Pirollo et al.   TRENDS IN BIOTECHNOLOGY