Identification of embelin, a 3‐undecyl‐1,4‐benzoquinone from Embelia ribes as a multitargeted anti‐Alzheimer agent

Cholinesterases and the fine line between poison and remedy

(2018) Carey N. Pope et al.   BIOCHEMICAL PHARMACOLOGY

Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer

(2018) Kirti S Prabhu et al.   Future Medicinal Chemistry

Identification of new allosteric sites and modulators of AChE through computational and experimental tools

(2018) Carlos Roca et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis

(2018) Sonali S. Bharate et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer’s Disease-Like Condition in a Rat Model

(2018) Saatheeyavaane Bhuvanendran et al.   Frontiers in Pharmacology

Ursolic and oleanolic acid derivatives with cholinesterase inhibiting potential

(2018) Anne Loesche et al.   BIOORGANIC CHEMISTRY

Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease

(2017) Qi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase

(2017) Lucie Heller et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

(2017) Terrone Rosenberry et al.   MOLECULES

Plant Derived Phytocompound, Embelin in CNS Disorders: A Systematic Review

(2017) Uday P. Kundap et al.   Frontiers in Pharmacology

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

(2016) Loqman A. Mohamed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease

(2016) Sultan Darvesh   Current Alzheimer Research

Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure–activity relationship

(2016) Sudhakar Manda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Structure–Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

(2016) Satish N. Dighe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticholinesterase activity of selected phenolic acids and flavonoids – interaction testing in model solutions

(2015) Dominik Szwajgier   ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

Plant alkaloids as drug leads for Alzheimer's disease

(2015) Yu Pong Ng et al.   NEUROCHEMISTRY INTERNATIONAL

Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model

(2015) G. Andrew Reid et al.   NEUROSCIENCE

Synthesis and P-glycoprotein induction activity of colupulone analogs

(2015) Jaideep B. Bharate et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and anti-proliferative activities of new derivatives of embelin

(2014) Baljinder Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models

(2014) Xue Wang et al.   BMC Complementary and Alternative Medicine

Synthesis, and the antioxidant, neuroprotective and P-glycoprotein induction activity of 4-arylquinoline-2-carboxylates

(2014) Jaideep B. Bharate et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects

(2013) Abeer E Abd El-Wahab et al.   BMC Complementary and Alternative Medicine

Molecular Recognition of Rosmarinic Acid fromSalvia sclareoidesExtracts by Acetylcholinesterase: A New Binding Site Detected by NMR Spectroscopy

(2013) Filipa Marcelo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

(2013) Eduardo Luis Konrath et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Early-onset Alzheimer's Disease: Nonamnestic Subtypes and Type 2 AD

(2012) Mario F. Mendez   ARCHIVES OF MEDICAL RESEARCH

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

(2012) Fredrik Jeppsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total synthesis and anti-cholinesterase activity of marine-derived bis-indole alkaloid fascaplysin

(2012) Sandip B. Bharate et al.   MedChemComm

CHOLINESTERASES, A TARGET OF PHARMACOLOGY AND TOXICOLOGY

(2011) Miroslav Pohanka   BIOMEDICAL PAPERS-OLOMOUC

Synthesis and Evaluation of Analgesic and Anti-inflammatory Activities of Most Active Free Radical Scavenging Derivatives of Embelin—A Structure–Activity Relationship

(2011) Sekar Mahendran et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Dual inhibition: a novel promising pharmacological approach for different disease conditions

(2011) Sazal Patyar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

(2011) Hong-Fang Ji et al.   MOLECULES

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia

(2011) C. Siegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY