Journal
NEUROSCIENCE
Volume 298, Issue -, Pages 424-435Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.04.039
Keywords
Alzheimer's disease; beta-amyloid; butyrylcholinesterase; 5XFAD mouse; butyrylcholinesterase-knock-out; cholinergic system
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Funding
- Canadian Institutes of Health Research [MOP-119343]
- Dalhousie Medical Research Foundation, Brain Repair Centre
- Capital District Health Authority Research Fund
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In Alzheimer's disease (AD), numerous beta-amyloid (A beta) plaques are associated with butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, containing five human familial AD genes (5XFAD), also develops A beta plaques with BChE activity. Knock-out of BChE in this model showed diminished fibrillar A beta plaque deposition, more so in males than females. This suggests that lack of BChE reduces deposition of fibrillar A beta in AD and this effect may be influenced by sex. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of IBRO.
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