Transient Ligand‐Enabled Transition Metal‐Catalyzed C−H Functionalization

Scalable, Stereocontrolled Formal Syntheses of (+)-Isoschizandrin and (+)-Steganone: Development and Applications of Palladium(II)-Catalyzed Atroposelective C−H Alkynylation

(2018) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transient-Ligand-Enabled ortho -Arylation of Five-Membered Heterocycles: Facile Access to Mechanochromic Materials

(2018) Bijin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-catalyzed site-selective arylation of aliphatic ketones enabled by a transient ligand

(2018) Lei Pan et al.   CHEMICAL COMMUNICATIONS

Palladium-catalyzed enantioselective C(sp2)–H arylation of ferrocenyl ketones enabled by a chiral transient directing group

(2018) Jiancong Xu et al.   CHEMICAL COMMUNICATIONS

Site-Selective γ-C(sp3 )−H and γ-C(sp2 )−H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group

(2018) Hua Lin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rh-catalyzed Transient Directing Group Promoted C-H Amidation of Benzaldehydes Utilizing Dioxazolones

(2018) Xiaoyang Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Carbon Dioxide-Mediated C(sp3)–H Arylation of Amine Substrates

(2018) Mohit Kapoor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-Catalyzed, ortho C–H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

(2018) Xiao-Yang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlling Pd(iv) reductive elimination pathways enables Pd(ii)-catalysed enantioselective C(sp3)−H fluorination

(2018) Hojoon Park et al.   Nature Chemistry

Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation

(2018) Sahra St John-Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines

(2018) Saegun Kim et al.   ORGANIC LETTERS

Direct Dehydrogenative Arylation of Benzaldehydes with Arenes Using Transient Directing Groups

(2018) Da-Yu Wang et al.   ORGANIC LETTERS

Ruthenium-Catalyzed Ortho C(sp2)–H Amidation of Benzaldehydes with Organic Azides

(2018) Omer Rasheed   SYNLETT

Direct synthesis of anthracenes from o -tolualdehydes and aryl iodides through Pd(II)-Catalyzed sp 3 C H arylation and electrophilic aromatic cyclization

(2018) Hyojin Park et al.   TETRAHEDRON

Ion Pair-Directed C–H Activation on Flexible Ammonium Salts: meta-Selective Borylation of Quaternized Phenethylamines and Phenylpropylamines

(2018) Madalina T. Mihai et al.   ACS Catalysis

Combining transition metals and transient directing groups for C–H functionalizations

(2018) Trisha Bhattacharya et al.   RSC Advances

Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis

(2018) Parthasarathy Gandeepan et al.   Chem

Palladium-Catalyzed β -C−H Arylation of Ketones Using Amino Amide as a Transient Directing Group: Applications to Synthesis of Phenanthridinone Alkaloids

(2018) Junliang Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium Catalyzed C(sp3)-H Arylation of Primary Amines Using a Catalytic Alkyl Acetal to Form a Transient Directing Group

(2018) Sahra St John-Campbell et al.   CHEMISTRY-A EUROPEAN JOURNAL

Amide Effects in C−H Activation: Noncovalent Interactions with L-Shaped Ligand for meta Borylation of Aromatic Amides

(2018) Ranjana Bisht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Atroposelective C−H Allylation through β-O Elimination: Diverse Synthesis of Axially Chiral Biaryls

(2018) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Overcoming the Limitations of γ- and δ-C–H Arylation of Amines through Ligand Development

(2018) Yan-Qiao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Polycyclic Aromatic Hydrocarbons (PAHs) via a Transient Directing Group

(2018) Ming Tang et al.   ORGANIC LETTERS

Iridium-Catalyzed ortho-C(sp2)–H Amidation of Benzaldehydes with Organic Azides

(2017) Delong Mu et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed Enantioselective C(sp3)–H Borylation

(2017) Jian He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diverse ortho-C(sp2)–H Functionalization of Benzaldehydes Using Transient Directing Groups

(2017) Xi-Hai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noncovalent Interactions in Ir-Catalyzed C–H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

(2017) Md Emdadul Hoque et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-Catalyzed Direct ortho-C–H Arylation of Aromatic Ketones Enabled by a Transient Directing Group

(2017) Jiancong Xu et al.   ORGANIC LETTERS

Synthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C–H Functionalizations Using a Transient Directing Group

(2017) Xiao-Yang Chen et al.   ORGANIC LETTERS

Pd-Catalyzed Ortho C–H Hydroxylation of Benzaldehydes Using a Transient Directing Group

(2017) Xiao-Yang Chen et al.   ORGANIC LETTERS

Assembly of Diverse Spirocyclic Pyrrolidines via Transient Directing Group Enabled Ortho-C(sp2)–H Alkylation of Benzaldehydes

(2017) Feng Li et al.   ORGANIC LETTERS

The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization

(2017) Tatiana Besset et al.   SYNTHESIS-STUTTGART

Single operation palladium catalysed C(sp3)–H functionalisation of tertiary aldehydes: investigations into transient imine directing groups

(2017) S. St John-Campbell et al.   Chemical Science

Methylene C(sp3)–H Arylation of Aliphatic Ketones Using a Transient Directing Group

(2017) Kai Hong et al.   ACS Catalysis

Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

(2017) Kang Chen et al.   Organic Chemistry Frontiers

Recent advances in positional-selective alkenylations: removable guidance for twofold C–H activation

(2017) Wenbo Ma et al.   Organic Chemistry Frontiers

Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis

(2016) Yan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Accelerated Direct C−H Arylation of BINOL: A Rapid One-Step Synthesis of Racemic 3,3′-Diaryl BINOLs

(2016) Jin-Fei Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic C(sp3)−H Arylation of Free Primary Amines with anexoDirecting Group Generated In Situ

(2016) Yan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp3)−H Bond Activation

(2016) Akira Yada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic C–H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand

(2016) Ke Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-Catalyzed γ-C(sp3)–H Arylation of Free Amines Using a Transient Directing Group

(2016) Yongwei Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled γ-C(sp3)–H Olefination of Amines: En Route to Pyrrolidines

(2016) Heng Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed C–H Arylation of Indoles at the C7 Position

(2016) Youqing Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Pair-Directed Regiocontrol in Transition-Metal Catalysis: A Meta-Selective C–H Borylation of Aromatic Quaternary Ammonium Salts

(2016) Holly J. Davis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic approaches towards alkaloids bearing α-tertiary amines

(2016) Anastasia Hager et al.   NATURAL PRODUCT REPORTS

Site-selective C–H arylation of primary aliphatic amines enabled by a catalytic transient directing group

(2016) Yongbing Liu et al.   Nature Chemistry

Acetohydrazone: A Transient Directing Group for Arylation of Unactivated C(sp3)–H Bonds

(2016) Fei Ma et al.   ORGANIC LETTERS

Functionalization of C(sp3)-H bonds using a transient directing group

(2016) F.-L. Zhang et al.   SCIENCE

Ligand-accelerated enantioselective methylene C(sp3)–H bond activation

(2016) Gang Chen et al.   SCIENCE

Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)–H bonds with acetonitrile

(2016) Yongbing Liu et al.   Chemical Science

Control over Organometallic Intermediate Enables Cp*Co(III) Catalyzed Switchable Cyclization to Quinolines and Indoles

(2016) Qingquan Lu et al.   ACS Catalysis

Oxazolinyl-Assisted C–H Amidation by Cobalt(III) Catalysis

(2016) Ruhuai Mei et al.   ACS Catalysis

Amine Functionalization via Oxidative Photoredox Catalysis: Methodology Development and Complex Molecule Synthesis

(2015) Joel W. Beatty et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ligand-Enabled Catalytic CH Arylation of Aliphatic Amines by a Four-Membered-Ring Cyclopalladation Pathway

(2015) Chuan He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bifunctional Ligand-Assisted Catalytic Ketone α-Alkenylation with Internal Alkynes: Controlled Synthesis of Enones and Mechanistic Studies

(2015) Fanyang Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A steric tethering approach enables palladium-catalysed C–H activation of primary amino alcohols

(2015) Jonas Calleja et al.   Nature Chemistry

A meta-selective C–H borylation directed by a secondary interaction between ligand and substrate

(2015) Yoichiro Kuninobu et al.   Nature Chemistry

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

(2015) Zhengkai Chen et al.   Organic Chemistry Frontiers

Alkaloids as Important Scaffolds in Therapeutic Drugs for the Treatments of Cancer, Tuberculosis, and Smoking Cessation

(2014) Prasat Kittakoop et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities

(2014) T.P. Tim Cushnie et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distortion/Interaction Analysis Reveals the Origins of Selectivities in Iridium-Catalyzed C–H Borylation of Substituted Arenes and 5-Membered Heterocycles

(2014) Aaron G. Green et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles

(2014) Andrew McNally et al.   NATURE

Regioselective ketone  -alkylation with simple olefins via dual activation

(2014) F. Mo et al.   SCIENCE

The Cross-Dehydrogenative Coupling of C sp 3H Bonds: A Versatile Strategy for CC Bond Formations

(2013) Simon A. Girard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Functionalization of C(sp2)H and C(sp3)H Bonds by Using Bidentate Directing Groups

(2013) Guy Rouquet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycal-Derived δ-Hydroxy α,β-Unsaturated Aldehydes (Perlin Aldehydes): Versatile Building Blocks in Organic Synthesis

(2013) L. Vijaya Raghava Reddy et al.   CHEMICAL REVIEWS

Total synthesis of the big four antibiotics and related antibiotics

(2013) Kuniaki Tatsuta   JOURNAL OF ANTIBIOTICS

Nickel-Catalyzed Direct Alkylation of C–H Bonds in Benzamides and Acrylamides with Functionalized Alkyl Halides via Bidentate-Chelation Assistance

(2013) Yoshinori Aihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(III)-Amine Dual Catalysis for the Oxidative Coupling of Aldehydes by Directed C–H Activation: Synthesis of Phthalides

(2013) Peng Wen Tan et al.   ORGANIC LETTERS

Efficient Approaches to the Stereoselective Synthesis of Cyclopropyl Alcohols

(2012) Hun Young Kim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cooperative Catalysis Approach to Intramolecular Hydroacylation

(2012) Evgeny V. Beletskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Functionalization of Unactivated sp3 C–H Bonds via exo-Directing Groups: Synthesis of Chemically Differentiated 1,2-Diols

(2012) Zhi Ren et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Outer-Sphere Direction in Iridium C–H Borylation

(2012) Philipp C. Roosen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Intermolecular C-Alkylation of 1,2-Diketones with Simple Olefins: A Recyclable Directing Group Strategy

(2012) Zhiqian Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inter- and intramolecular hydroacylation of alkenes employing a bifunctional catalyst system

(2011) Nicolas R. Vautravers et al.   CHEMICAL COMMUNICATIONS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhenium-Catalyzed Synthesis of Indenones by Novel Dehydrative Trimerization of Aryl Aldehydes via C−H Bond Activation

(2010) Yoichiro Kuninobu et al.   ORGANIC LETTERS

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition Metal Catalyzed Alkene and Alkyne Hydroacylation

(2009) Michael C. Willis   CHEMICAL REVIEWS

Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis

(2009) Graham E. Dobereiner et al.   CHEMICAL REVIEWS

Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations

(2008) Chao-Jun Li   ACCOUNTS OF CHEMICAL RESEARCH

Simple rhodium–chlorophosphine pre-catalysts for the ortho-arylation of phenols

(2008) Robin B. Bedford et al.   CHEMICAL COMMUNICATIONS