Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 48, Pages 15762-15766Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201809929
Keywords
amides; C-H activation; borylation; iridium; noncovalent interactions
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Funding
- DST-SERB [SB/S2/RJN-45/2013, SB/FT/CS-141/2014]
- CSIR
- UGC
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A new concept for the meta-selective borylation of aromatic amides is described. It has been demonstrated that while esters gave para borylations, amides lead to meta borylations. For achieving high meta selectivity, an L-shaped bifunctional ligand has been employed and engages in an O center dot center dot center dot K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for meta C-H activation/borylation.
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