Journal
JOURNAL OF ANTIBIOTICS
Volume 66, Issue 3, Pages 107-129Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2012.126
Keywords
antibiotics; carbohydrates; enantiospecific synthesis; natural products; total synthesis
Funding
- Research Institute for Science and Engineering, Waseda University
- Consolidated Research Institute for Advanced Science and Medical Care
- Global COE program 'Center for Practical Chemical Wisdom'
- Scientific Research on Priority Area 'Creation of Biologically Functional Molecules' Ministry of Education, Culture, Sports, Science and Technology
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The first total syntheses of a variety of antibiotics have been accomplished by using carbohydrates as a chiral source. The key target molecules were members of the 'Big Four' classes of antibiotics (macrolides, aminoglycosides, beta-lactams and tetracyclines), naphthoquinone antibiotics and their related antibiotics. The Journal of Antibiotics (2013) 66, 107-129; doi: 10.1038/ja.2012.126
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