Oncometabolites in cancer aggressiveness and tumour repopulation

Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation

(2018) Zaal Kokaia et al.   Cell Stem Cell

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase–mutated intrahepatic cholangiocarcinomas

(2018) Julia Delahousse et al.   EUROPEAN JOURNAL OF CANCER

The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes

(2018) Aaron M. Udager et al.   HUMAN PATHOLOGY

microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings

(2018) Chi Fang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomal miRNAs in hepatocellular carcinoma development and clinical responses

(2018) Shuangshuang Li et al.   Journal of Hematology & Oncology

Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer

(2018) Jie Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cancer secretome and secreted biomarkers

(2018) Massimo Donadelli   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autocrine mechanisms of cancer chemoresistance

(2018) Giovanna Butera et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Exosomes in cancer: Use them or target them?

(2018) Nuno Bastos et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Secreted molecules inducing epithelial-to-mesenchymal transition in cancer development

(2018) Elisa Dalla Pozza et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation

(2018) Lina Zhou et al.   JOURNAL OF PROTEOME RESEARCH

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

(2018) Baharan Fekry et al.   Nature Communications

Succinate dehydrogenase (SDH)-deficient neoplasia

(2017) Anthony J Gill   HISTOPATHOLOGY

Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells

(2017) Hsiang-Cheng Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment

(2017) Liliana E. Lucca et al.   JOURNAL OF CLINICAL INVESTIGATION

O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency

(2017) Ting Wang et al.   NATURE CELL BIOLOGY

Mitochondrial Complex II: At the Crossroads

(2017) Ayenachew Bezawork-Geleta et al.   TRENDS IN BIOCHEMICAL SCIENCES

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway

(2017) Lianzhi Cui et al.   OncoTargets and Therapy

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

(2017) Petros A. Tyrakis et al.   Cell Reports

Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases

(2017) Ryan Janke et al.   eLife

Platelet-activating factor (PAF) receptor as a promising target for cancer cell repopulation after radiotherapy

(2017) I A da Silva-Jr et al.   Oncogenesis

Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission

(2017) So Hee Ko et al.   Scientific Reports

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

(2016) Laszlo Tretter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Exosomes secreted from human colon cancer cells influence the adhesion of neighboring metastatic cells: Role of microRNA-210

(2016) Elisabetta Bigagli et al.   CANCER BIOLOGY & THERAPY

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

(2016) Xiaozhen He et al.   CANCER RESEARCH

TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma

(2016) Giacomo Lettini et al.   CELL DEATH AND DIFFERENTIATION

Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate

(2016) Maxime Janin et al.   Cell Metabolism

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Oncometabolites: Unconventional triggers of oncogenic signalling cascades

(2016) Marco Sciacovelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling

(2016) Sergiy M. Nadtochiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas

(2016) Susan Richter et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma

(2016) Daisy PF Tsang et al.   JOURNAL OF PATHOLOGY

Isocitrate dehydrogenase mutations in myeloid malignancies

(2016) B C Medeiros et al.   LEUKEMIA

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Insight into SUCNR1 (GPR91) structure and function

(2016) Julie Gilissen et al.   PHARMACOLOGY & THERAPEUTICS

SDHB deficiency promotes TGFβ-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4

(2016) Haiyu Wang et al.   Translational Oncology

miRNA Deregulation in Cancer Cells and the Tumor Microenvironment

(2016) R. Rupaimoole et al.   Cancer Discovery

Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers

(2016) Stephanie N. Hurwitz et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism

(2016) Man Ryul Lee et al.   Stem Cell Reports

MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers

(2016) Pannapa Pinweha et al.   Computational and Structural Biotechnology Journal

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

(2016) Hugh Colvin et al.   Scientific Reports

MicroRNA in radiotherapy: miRage or miRador?

(2015) E Korpela et al.   BRITISH JOURNAL OF CANCER

Prostaglandin E2 Inhibits p53 in Human Breast Adipose Stromal Cells: A Novel Mechanism for the Regulation of Aromatase in Obesity and Breast Cancer

(2015) X. Wang et al.   CANCER RESEARCH

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

(2015) William M. Oldham et al.   Cell Metabolism

Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation

(2015) K. S. Chan   CLINICAL CANCER RESEARCH

Structural and functional consequences of succinate dehydrogenase subunit B mutations

(2015) E. Kim et al.   ENDOCRINE-RELATED CANCER

Immunohistochemical expression of stem cell markers in pheochromocytomas/paragangliomas is associated with SDHx mutations

(2015) L. Oudijk et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Oncometabolites: tailoring our genes

(2015) Stefan Nowicki et al.   FEBS Journal

MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

(2015) Yuqin Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

(2015) Tuomas Laukka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel splice site mutation in the fumarate hydratase (FH) gene is associated with multiple cutaneous leiomyomas in a Japanese patient

(2015) Yukina Yoshinaga et al.   JOURNAL OF DERMATOLOGY

Insulator dysfunction and oncogene activation in IDH mutant gliomas

(2015) William A. Flavahan et al.   NATURE

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

(2015) Yuhui Jiang et al.   NATURE CELL BIOLOGY

Mutational landscape and clonal architecture in grade II and III gliomas

(2015) Hiromichi Suzuki et al.   NATURE GENETICS

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors

(2015) Attje S. Hoekstra et al.   Oncotarget

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

(2015) Céline Loriot et al.   Oncotarget

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation

(2015) Anjali K. Nath et al.   Cell Reports

Expressions of Hypoxia-Inducible Factor-1 and Epithelial Cell Adhesion Molecule are Linked with Aggressive Local Recurrence of Hepatocellular Carcinoma After Radiofrequency Ablation Therapy

(2014) Shinichiro Yamada et al.   ANNALS OF SURGICAL ONCOLOGY

The role of mutation of metabolism-related genes in genomic hypermethylation

(2014) Joshua J. Waterfall et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells

(2014) Lucian Beer et al.   BMC GENOMICS

Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer

(2014) Carole Sourbier et al.   CANCER CELL

IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma

(2014) Morteza Esmaeili et al.   CANCER RESEARCH

Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers

(2014) G. N. Gan et al.   CANCER RESEARCH

Pheochromocytoma and paraganglioma syndromes: genetics and management update

(2014) M. Lefebvre et al.   Current Oncology

Overexpression of miR-210 is associated with SDH-related pheochromocytomas, paragangliomas, and gastrointestinal stromal tumours

(2014) V H M Tsang et al.   ENDOCRINE-RELATED CANCER

Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) – A review

(2014) Markku Miettinen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling

(2014) Karthigayan Shanmugasundaram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma

(2014) Jin Cheng et al.   Molecular Oncology

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

(2014) Antonina V. Kurtova et al.   NATURE

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

(2014) Andrea Rasola et al.   TRENDS IN CELL BIOLOGY

The Impact of Extracellular Vesicle-Encapsulated Circulating MicroRNAs in Lung Cancer Research

(2014) Yu Fujita et al.   Biomed Research International

Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors

(2013) Bora E. Baysal   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Role of hypoxia inducible factor-1α for interferon synthesis in mouse dendritic cells

(2013) Regina Wobben et al.   BIOLOGICAL CHEMISTRY

Succinate: A New Epigenetic Hacker

(2013) Ming Yang et al.   CANCER CELL

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase

(2013) Marco Sciacovelli et al.   Cell Metabolism

MicroRNA and signal transduction pathways in tumor radiation response

(2013) Luqing Zhao et al.   CELLULAR SIGNALLING

Mild clinical presentation and prolonged survival of a patient with fumarase deficiency due to the combination of a known and a novel mutation in FH gene

(2013) Fatih Ezgu et al.   GENE

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

(2013) Luis Jaime Castro-Vega et al.   HUMAN MOLECULAR GENETICS

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

The growing role of eicosanoids in tissue regeneration, repair, and wound healing

(2013) Brian T. Kalish et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The roles of extracellular vesicles in cancer biology: Toward the development of novel cancer biomarkers

(2013) Takeshi Katsuda et al.   PROTEOMICS

Cell Death–Stimulated Cell Proliferation: A Tissue Regeneration Mechanism Usurped by Tumors During Radiotherapy

(2013) Mary A. Zimmerman et al.   SEMINARS IN RADIATION ONCOLOGY

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

(2013) Julie Adam et al.   Cell Reports

Hypoxia-inducible C-to-U coding RNA editing downregulatesSDHBin monocytes

(2013) Bora E. Baysal et al.   PeerJ

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Elevated plasma succinate in PTEN, SDHB and SDHD mutation–positive individuals

(2012) Judith A. Hobert et al.   GENETICS IN MEDICINE

A two-dimensional screen for AMPK substrates identifies tumor suppressor fumarate hydratase as a preferential AMPKα2 substrate

(2012) Anna Klaus et al.   Journal of Proteomics

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

MicroRNAs in metabolism and metabolic disorders

(2012) Veerle Rottiers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic control of renin secretion

(2012) János Peti-Peterdi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Possible Role of Exosomes Containing RNA in Mediating Nontargeted Effect of Ionizing Radiation

(2012) Ammar H. J. Al-Mayah et al.   RADIATION RESEARCH

Downregulation of Fumarate Hydratase Is Related to Tumorigenesis in Sporadic Renal Cell Cancer

(2012) Yun-Sok Ha et al.   UROLOGIA INTERNATIONALIS

The emerging role of fumarate as an oncometabolite

(2012) Ming Yang et al.   Frontiers in Oncology

SDH mutations in cancer

(2011) Chiara Bardella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells

(2011) Diana M Vallejo et al.   EMBO JOURNAL

Structural basis of fumarate hydratase deficiency

(2011) Sarah Picaud et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer

(2011) Francesca De Bacco et al.   JNCI-Journal of the National Cancer Institute

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

Caspase-3 and prostaglandins signal for tumor regrowth in cancer therapy

(2011) L Galluzzi et al.   ONCOGENE

Apoptosis induction and tumor cell repopulation: The yin and yang of radiotherapy

(2011) Kirsten Lauber et al.   Radiation Oncology

MicroRNA expression profiles in human cancer cells after ionizing radiation

(2011) Olivier M Niemoeller et al.   Radiation Oncology

MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3′ untranslated region

(2010) Shu Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

miR-378 ∗ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway

(2010) Lillian J. Eichner et al.   Cell Metabolism

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

(2010) Ohad Yogev et al.   PLOS BIOLOGY

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

(2009) Takuya Watanabe et al.   AMERICAN JOURNAL OF PATHOLOGY

UOK 262 cell line, fumarate hydratase deficient (FH−/FH−) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

(2009) Youfeng Yang et al.   CANCER GENETICS AND CYTOGENETICS

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

MicroRNA-206 Targetsnotch3, Activates Apoptosis, and Inhibits Tumor Cell Migration and Focus Formation

(2009) Guisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI3-K/AKT-Pathway and Radiation Resistance Mechanisms in Non-small Cell Lung Cancer

(2009) Olga C.J. Schuurbiers et al.   Journal of Thoracic Oncology

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency

(2008) Jean-Pierre Bayley et al.   BMC Medical Genetics

Distinct Mechanisms of Apoptosis-Induced Compensatory Proliferation in Proliferating and Differentiating Tissues in the Drosophila Eye

(2008) Yun Fan et al.   DEVELOPMENTAL CELL

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY

NF-κB-MediatedHER2Overexpression inRadiation-Adaptive Resistance

(2008) Ning Cao et al.   RADIATION RESEARCH

A cancer-predisposing “hot spot” mutation of the fumarase gene creates a dominant negative protein

(2007) Annalisa Lorenzato et al.   INTERNATIONAL JOURNAL OF CANCER