TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer

(2015) Elmer Hoekstra et al.   Oncotarget

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma

(2015) Valentina Condelli et al.   Oncotarget

Mitochondria as therapeutic targets for cancer stem cells

(2015) In Sung Song   World Journal of Stem Cells

A Phosphorylation-Related Variant ADD1-rs4963 Modifies the Risk of Colorectal Cancer

(2015) Na Shen et al.   PLoS One

Molecular identification and targeting of colorectal cancer stem cells

(2015)   Oncotarget

Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling

(2014) Andreas Herbst et al.   BMC GENOMICS

TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors

(2014) V. Condelli et al.   CANCER RESEARCH

Cancer stem cells - important players in tumor therapy resistance

(2014) Selcuk Colak et al.   FEBS Journal

Guardian of the Furnace: Mitochondria, TRAP1, ROS and stem cell maintenance

(2014) Rose Kadye et al.   IUBMB LIFE

TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: Relevance in human colorectal tumors

(2014) Danilo Swann Matassa et al.   Molecular Oncology

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combination of TRAP1 and ERCC1 Expression Predicts Clinical Outcomes in Metastatic Colorectal Cancer Treated with Oxaliplatin/5-Fluorouracil

(2014) Jae Joon Han et al.   Cancer Research and Treatment

The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase

(2013) Marco Sciacovelli et al.   Cell Metabolism

Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1

(2013) Francesca Maddalena et al.   Molecular Oncology

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

(2013) Anguraj Sadanandam et al.   NATURE MEDICINE

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

(2013) S. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1

(2013) D S Matassa et al.   Cell Death & Disease

Landscape of the mitochondrial Hsp90 metabolome in tumours

(2013) Young Chan Chae et al.   Nature Communications

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

(2013) Oksana Voloshanenko et al.   Nature Communications

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

(2012) Jurian Schuijers et al.   EMBO JOURNAL

Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer

(2012) Jing-Yan Gao   WORLD JOURNAL OF GASTROENTEROLOGY

TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins

(2011) M R Amoroso et al.   CELL DEATH AND DIFFERENTIATION

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

(2011) Markus D. Siegelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Chaperone Trap1 and the Calcium Binding Protein Sorcin Interact and Protect Cells against Apoptosis Induced by Antiblastic Agents

(2010) M. Landriscina et al.   CANCER RESEARCH

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells

(2009) Eleonora Costantino et al.   CANCER LETTERS

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

(2008) L. Du et al.   CLINICAL CANCER RESEARCH